Toll-like receptor 4 signal pathway may be involved in cerebral ischemic tolerance induced by hypoxic preconditioning: Experiment with rats

National Medical Journal of China

Volumn 87, Issue 35, 2007, Pages 2458-2462

  Li, Yong Wang ^a   Jin, Hai Long ^a   Wang, Bao Guo ^a   Shi, Zhong Hua ^a   Li, Jin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Asphyxia; Brain ischemic tolerance; Ischemic preconditioning

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APNEA; ARTICLE; ASSISTED VENTILATION; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; GENE EXPRESSION; HEART ARREST; HYPOXIA; ISCHEMIC PRECONDITIONING; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RAT; RESUSCITATION; SCORING SYSTEM; SIGNAL TRANSDUCTION; SURVIVAL RATE; WISTAR RAT;

ANIMALS; BRAIN ISCHEMIA; CARDIOPULMONARY RESUSCITATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-6; ISCHEMIC PRECONDITIONING; MALE; NF-KAPPA B; RANDOM ALLOCATION; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 37149021590     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Xiao F, Pardue S, Arnold T, et al. Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. Resuscitation, 2004,61:209-219.
2. Gidday JM. Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci, 2006, 7:437-448.
3. Kariko K, Weissman D, Welsh FA. Inhibition of toll-like receptor and cytokine signaling: a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab, 2004, 24:1288-1304.
4. Chinese source.
5. Chinese source.
6. Chinese source.
7. Chinese source.
8. Geocadin RG, Malhotra AD, Tong S, et al. Effect of acute hypoxic preconditioning on qEEG and functional recovery after cardiac arrest in rats. Brain Res, 2005, 7: 1064:146-154.
9. McCaul CL, McNamara PJ, Engelberts D, et al. Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model. Anesth Analg, 2006,102:542-548.
10. Bowen KK, Naylor M, Vemuganti R. Prevention of inflammation is a mechanism of preconditioning-induced neuroprotection against focal cerebral ischemia. Neurochem Int, 2006,49:127-135.
11. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature, 2000, 406: 782-787.
12. Baeburn CD, Sheppard F, Barsness KA, et al. Cytokines for surgeons. Am J Surg, 2002, 183: 268-273.
13. Song M, Kellum JA. Interleukin-6. Crit Care Med, 2005,33:S463-465.
14. Caso JR, Pradillo JM, Hurtado O, et al. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation, 2007, 115:1599-1608.