Synthesis and reactivity of 4H-triazoles

Journal of the Chemical Society, Chemical Communications

Volumn , Issue 20, 1980, Pages 940-941

  Bernard, Christiane ^a   Ghosez, Léon ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 37049100556     PISSN: 00224936     EISSN: None     Source Type: Journal    
DOI: 10.1039/c39800000940     Document Type: Article

References (8)

1. M. Rens and L. Ghosez, Tetrahedron Lett., 1970, 3765
2. L. Ghosez in ‘Medicinal Chemistry,’ Vol. 5, ed. J. Mathieu, Elsevier Scientific Publishing Company, Amsterdam, Oxford, New York, 1977, p. 363
3. H. Heimgartner, Chimia, 1979, 33 111
4. M. Henriet, M. Houtekie, B. Techy, R. Touillaux, and L. Ghosez, Tetrahedron Lett., 1980, 223.
5. A synthesis of a 5-amino-4H-triazole has been claimed by K. Hohenlohe-Oeringen, Montash Chem., 1958, B89, 557. However, spectroscopic data do not differentiate between the proposed structure or the tautomeric imine.
6. α-Chlorenamines (5) were first described by R. Buyle and H. G. Viehe, Tetrahedron, 1968, 24, 4217; 1969, 25, 3447.
7. Yields were rather poor. Our procedure is based on the experimental modification proposed by G. Winters, N. Di Maha, E. Oppico, and C. Nathansahu, II Farmaco, 1975, 30, 620.
8. J. P. Declercq, G. Germain, R. Touillaux, M. Van Meerssche, C. Bernard, and L. Ghosez, Acta Crystallogr., submitted for publication.