Displacement of a nitro-group by [18F] fluoride ion. A new route to aryl flurides of high specific activity

Journal of the Chemical Society - Series Chemical Communications

Volumn , Issue 3, 1983, Pages 108-109

  Attiná, Marina ^a   Cacace, Fulvio ^a   Wolf, A P ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 37049093220     PISSN: 00224936     EISSN: None     Source Type: Journal    
DOI: 10.1039/C39830000108     Document Type: Article

References (6)

1. A. P. Wolf, Semin. Nucl. Med.,1981, 11, 2;
2. J. S. Fowler and A. P. Wolf, ‘The Synthesis of nC, 18F and 13N Labeled Radiotracers for Biomedical Applications,’ NAS-NS-3201, National Academy of Sciences, National Research Council, National Technical Information Series, 1982.
3. F. Cacace, M. Speranza, A. P. Wolf, and J. S. Fowler, J. Labelled Comp. Radiopharm., 1981, 18, 1721.
4. J. F. Bunnet and R. E. Zahler, Chem. Rev.,1951, 69, 273.
5. The leaving ability of N02 is higherthan of F in the reaction studied, which represents an exception of the general leaving ability order established for nucleophilic aromatic substitution. Such ‘exceptions’ are however quite common, and it has been reported, for instance, that nucleofugality of N02 exceeds that of F by a factor of 12.6 in the nucleophilic displacement by aniline, ef.R. E. Parker and T. O. Red, J. Chem. Soc.,1962, 3149.
6. Cf.J. S. Fowler, C. D. Arnett, A. P. Wolf, R. R. MacGregor, E. F. Norton, and A. M. Findley, J. Nucl. Med.,1982, 23, 437.