Exceptional active site H-bonding in enzymes? Significance of the 'oxyanion hole' in the serine proteases from a model study

Journal of the Chemical Society, Perkin Transactions 2

Volumn , Issue 11, 1995, Pages 2069-2074

  Mock, William L ^a   Chua, Dave C Y ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 37049069772     PISSN: 1472779X     EISSN: None     Source Type: Journal    
DOI: 10.1039/p29950002069     Document Type: Article

References (31)

1. A. J. White, K. Drabble, S. Ward and C. W. Wharton, Biochem. J., 1992, 287, 317;
2. P. J. Tonge and P. R. Carey, Biochemistry, 1992,31,9122.
3. D. M. Blow, Acc. Chem. Res., 1976, 9, 145;
4. R. M. Sweet, H. T. Wright, J. Janin, C. H. Chothia and D. M. Blow, Biochemistry, 1974,13,4212;
5. M. D. Finucane and J. P. G. Malthouse, Biochem. J., 1992,286, 889;
6. A. Warshel, G. Naray-Szabo, F. Sussman and J.-K. Hwang, Biochemistry, 1989,28, 3629.
7. P. Bryan, M. W. Pantoliano, S. G. Quill, H.-Y. Hsiao and T. Poulos, Proc. Natl. Acad. Sci. USA, 1986,83,3743;
8. J. A. Wells, B. C. Cunningham, T. P. Graycar and D. A. Estell, Phil. Trans. R. Soc. London, 1986, A317,415;
9. P. Carter and J. A. Wells, Proteins: Struct., Fund., Genet., 1990, 7, 335;
10. P. Carter, L. Abrahmsen and J. A. Wells, Biochemistry, 1991, 30, 6142;
11. R. Menard, J. Carriere, P. Laflamme, C. Plouffe, H. E. Khouri, T. Vernet, D. C. Tessier, D. Y. Thomas and A. C. Storer, Biochemistry, 1991, 30, 8924.
12. J. A. Gerlt and P. G. Gassman, Biochemistry, 1993, 32, 11943;
13. J. A. Gerlt and P. G. Gassman, J. Am. Chem. Soc., 1993,115,11552;
14. W. W. Cleland and M. M. Kreevoy, Science, 1994, 264, 1887.
15. L. Pauling, Am. Sci., 1948, 36, 51;
16. W. P. Jencks, Adv. Enzymol. Relat. Areas Mol. Biol., 1975,43,219;
17. R. L. Schowen, in Transition States of Biochemical Processes, Plenum, New York, 1978, pp.77-114.
18. W. P. Jencks, Chem. Rev., 1972, 72, 705;
19. J. P. Fox and W. P. Jencks, J. Am. Chem. Soc., 1974, 96, 1436;
20. A. C. Satterthwait and W. P. Jencks, J. Am. Chem. Soc., 1974, 96, 7018 and 7031;
21. T.-C. Liang and R. H. Abeles, Biochemistry, 1987, 26, 7603.
22. N. Stahl and W. P. Jencks, J. Am. Chem. Soc., 1986,108,4196.
23. I. D. Sadekov, V. I. Minkin and A. E. Lutskii, Russ. Chem. Rev., 1970,39, 179.
24. M. H. Abraham, Chem. Soc. Rev., 1993, 22, 73.
25. R. Taylor and O. Kennard, Acc. Chem. Res., 1984,17, 320.
26. P. Gilli, V. Bertolasi, V. Ferretti and G. Gilli, J. Am. Chem. Soc., 1994,116, 909.
27. W. L. Mock and J. Z. Zhang, J. Biol. Chem., 1991, 266, 6393.
28. W. L. Mock, D. J. Freeman and M. Aksamawati, Biochem. J., 1993, 289, 185.
29. W. L. Mock and M. Aksamawati, Biochem. J., 1994, 302, 57.
30. W. L. Mock and X. Xu, Bioorg. Chem., 1994, 22, 373.
31. J. P. Guthrie and R. Kluger, J. Am. Chem. Soc., 1993, 115, 11569.