Diagnostic value of Elecsys S100 as a marker of acute brain injury in the emergency department

Journal of Clinical Laboratory Analysis

Volumn 21, Issue 6, 2007, Pages 387-392

  Oh, Eun Jee ^a   Kim, Young Min ^a   Jegal, Dong Wook ^a   Kahng, Jimin ^a   Park, Yeon Joon ^a   Han, Kyungja ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Acute brain injury; Elecsys S100; Emergency department; Screening; Serum marker

Indexed keywords

PROTEIN S 100;

ADULT; ARTICLE; BRAIN INJURY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DISEASE MARKER; EMERGENCY WARD; FEMALE; GLASGOW COMA SCALE; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; SCREENING TEST; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BRAIN INJURIES; BRAIN INJURY, CHRONIC; EMERGENCY SERVICE, HOSPITAL; FEMALE; GLASGOW COMA SCALE; HUMANS; IMMUNOASSAY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; S100 PROTEINS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 37049028832     PISSN: 08878013     EISSN: 10982825     Source Type: Journal    
DOI: 10.1002/jcla.20201     Document Type: Article

References (19)

1. Graham ID, Stiell IG, Laupacis A, O'Connor AM, Wells GA. Emergency physicians' attitudes toward and use of clinical decision rules for radiography. Acad Emerg Med 1998;5:134-140.
2. Ingebrigtsen T, Romner B, Marup-Jensen S, et al. The clinical value of serum S-100 protein measurements in minor head injury: a Scandinavian multicentre study. Brain Inj 2000;14:1047-1055.
3. Biberthaler P, Linsenmeier U, Pfeifer KJ, et al. Serum S-100B concentration provides additional information for the indication of computed tomography in patients after minor head injury: a prospective multicenter study. Shock 2006;25:446-453.
4. Biberthaler P, Mussack T, Wiedemann E, et al. Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma. Shock 2001;16:97-101.
5. Schafer BW, Heizmann CW. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci 1996;21:134-140.
6. Haimoto H, Hosoda S, Kato K. Differential distribution of immunoreactive S100-alpha and S100-beta proteins in normal nonnervous human tissues. Lab Invest 1987;57:489-498.
7. Rothoerl RD, Woertgen C, Holzschuh M, Metz C, Brawanski A. S-100 serum levels after minor and major head injury. J Trauma 1998;45:765-767.
8. Persson L, Hardemark HG, Gustafsson J, et al. S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system. Stroke 1987;18:911-918.
9. Buttner T, Weyers S, Postert T, Sprengelmeyer R, Kuhn W. S-100 protein: serum marker of focal brain damage after ischemic territorial MCA infarction. Stroke 1997;28:1961-1965.
10. Wiesmann M, Missler U, Hagenstrom H, Gottmann D. S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage. Acta Neurochir (Wien) 1997;139:1155-1160.
11. Griffin WS, Yeralan O, Sheng JG, et al. Overexpression of the neurotrophic cytokine S100 beta in human temporal lobe epilepsy. J Neurochem 1995;65:228-233.
12. Shackford SR, Wald SL, Ross SE, et al. The clinical utility of computed tomographic scanning and neurologic examination in the management of patients with minor head injuries. J Trauma 1992;33:385-394.
13. Stein SC, Ross SE. The value of computed tomographic scans in patients with low-risk head injuries. Neurosurgery 1990;26:638-640.
14. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease study. Lancet 1997;349:1269-1276.
15. Kahn HJ, Baumal R, Van Eldik LJ, Dunn RJ, Marks A. Immunoreactivity of S100 beta in heart, skeletal muscle, and kidney in chronic lung disease: possible induction by cAMP. Mod Pathol 1991;4:698-701.
16. Alber B, Hein R, Garbe C, Caroli U, Luppa PB. Multicenter evaluation of the analytical and clinical performance of the Elecsys S100 immunoassay in patients with malignant melanoma. Clin Chem Lab Med 2005;43:557-563.
17. Anderson RE, Hansson LO, Nilsson O, Liska J, Settergren G, Vaage J. Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources. Ann Thorac Surg 2001;71:1512-1517.
18. Abraha HD, Butterworth RJ, Bath PM, Wassif WS, Garthwaite J, Sherwood RA. Serum S-100 protein, relationship to clinical outcome in acute stroke. Ann Clin Biochem 1997;34:366-370.
19. Mussack T, Kirchhoff C, Buhmann S, et al. Significance of Elecsys S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients. Clin Chem Lab Med 2006;44:1140-1145.