Synthesis of a 5-((Aryloxy)methyl)-3-(4-(trifluoromethyl)phenyl)[1,2,4] thiadiazole derivative: A promising PPARα,δ agonist

Organic Process Research and Development

Volumn 11, Issue 6, 2007, Pages 1010-1014

  Reuman, Michael ^a   Hu, Zhiyong ^a   Kuo, Gee Hong ^a   Li, Xun ^a   Russell, Ronald K ^a   Shen, Lan ^a   Youells, Scott ^a   Zhang, Yongzheng ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

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[No Author keywords available]

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EID: 37049025570     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op700141u     Document Type: Article

References (15)

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3. (b) Shi, Y.; Hon, M.; Evans, R. M. Proc. Natl. Acad. Sci. USA 2002, 99, 2613.
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5. Suzuki, H.; Kimura, Y. J. Fluorine Chem. 1991, 52, 341 (describes this method applied to a similar amide).
6. The dipolar addition reaction of nitrile sulfides and ethyl cyanoformate has been described in: Howe, R. K.; Franz, J. E. J. Org. Chem. 1974, 39, 962.
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