HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis

International Journal of Cardiology

Volumn 123, Issue 2, 2008, Pages 84-90

  Kuwahara, Noriko ^a   Sasaki, Susumu ^a   Kobara, Miyuki ^b   Nakata, Tetsuo ^b   Tatsumi, Tetsuya ^a   Irie, Hidekazu ^a   Narumiya, Hiromichi ^a   Hatta, Tsuguru ^a   Takeda, Kazuo ^a   Matsubara, Hiroaki ^a   Hushiki, Shinji ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Ageing; Arteriosclerosis; HMG CoA reductase inhibitor; Klotho; Nitric oxide synthase

Indexed keywords

ATORVASTATIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KLOTHO PROTEIN; LIPID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PITAVASTATIN; STATINE DERIVATIVE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOSCLEROSIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME INHIBITION; GENE; GENE EXPRESSION; HOMOZYGOSITY; HYPERTENSION; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE; KLOTHO GENE; LIPID ANALYSIS; LIPID BLOOD LEVEL; MORBIDITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SYNTHESIS; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ARTERIOSCLEROSIS; GLUCURONIDASE; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; NITRIC OXIDE SYNTHASE; PYRROLES; QUINOLINES; RATS; RATS, WISTAR;

EID: 37049021538     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2007.02.029     Document Type: Article

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