Brain-derived neurotrophic factor prevents human immunodeficiency virus type 1 protein gp120 neurotoxicity in the rat nigrostriatal system

Annals of the New York Academy of Sciences

Volumn 1122, Issue , 2007, Pages 144-154

  Mocchetti, Italo ^a   Nosheny, Rachel L ^a   Tanda, Gianluigi ^b   Ren, Ke ^c   Meyer, Edwin M ^c  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

BDNF; CXCR4; Dopamine; HIV associated dementia; Neuronal apoptosis; Neuroprotection; Substantia nigra

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; GLYCOPROTEIN GP 120; VIRUS VECTOR;

APOPTOSIS; BRAIN REGION; CHEMICAL ANALYSIS; CONFERENCE PAPER; DEMENTIA; DOPAMINERGIC NERVE CELL; HISTOCHEMISTRY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NERVE CELL DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PREVENTION AND CONTROL; STRIATONIGRAL DEGENERATION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; RATTUS; RODENTIA;

EID: 37049008854     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1403.010     Document Type: Conference Paper

References (45)

1. EVERALL, I.P., L.A. HANSEN & E. MASLIAH. 2005. The shifting patterns of HIV encephalitis neuropathology. Neurotox. Res. 8: 51-61.
2. JAMES, H.J. et al. 1999. Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis. Neuropathol. Appl. Neurobiol. 25: 380-386.
3. GRAY, F. et al. 2001. Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments. Clin. Neuropathol. 20: 146-155.
4. MASLIAH, E. et al. 2000. Changes in pathological findings at autopsy in AIDS cases for the last 15 years. AIDS 14: 69-74.
5. HESSELGESSER, J. et al. 1998. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Curr. Biol. 8: 595-598.
6. ENDRES, M. et al. 1996. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 87: 745-756.
7. LAZARINI, F. et al. 2003. Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia 42: 139-148.
8. VAN DER MEER, P. et al. 2000. Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia. Exp. Mol. Pathol. 69: 192-201.
9. MEUCCI, O. et al. 1998. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc. Natl. Acad. Sci. USA 95: 14500-14505.
10. KAUL, M. & S.A. LIPTON. 1999. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc. Natl. Acad. Sci. USA 96: 8212-8216.
11. KRUMAN, I.I., A. NATH & M.P. MATTSON. 1998. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp. Neurol. 154: 276-288.
12. MCARTHUR, J.C. 2004. HIV dementia: an evolving disease. J. Neuroimmunol. 157: 3-10.
13. TOGGAS, S.M. et al. 1994. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367: 188-193.
14. D'HOOGE, R. et al. 1999. Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120. Eur. J. Neurosci. 11: 4398-4402.
15. MICHAUD, J. et al. 2001. Neuropathology of NFHgp160 transgenic mice expressing HIV-1 env protein in neurons. J. Neuropathol. Exp. Neurol. 60: 574-587.
16. NATH, A. et al. 2000. Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia. J. Psychopharmacol. 14: 222-227.
17. KOUTSILIERI, E. et al. 2002. Parkinsonism in HIV dementia. J. Neural. Transm. 109: 767-775.
18. BERGER, J.R. & G. ARENDT. 2000. HIV dementia: the role of the basal ganglia and dopaminergic systems. J. Psychopharmacol. 14: 214-221.
19. BANISADR, G. et al. 2002. Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. Eur. J. Neurosci. 16: 1661-1671.
20. NOSHENY, R.L. et al. 2004. Human immunodeficiency virus type 1 glycoprotein gp120 reduces the levels of brain-derived neurotrophic factor in vivo: potential implication for neuronal cell death. Eur. J. Neurosci. 20: 2857-2864.
21. BACHIS, A. et al. 2006. Axonal transport of human immunodeficiency virus type 1 envelope glycoprotein 120 is found in association with neuronal apoptosis. J. Neurosci. 26: 6771-6780.
22. DAHLSTROEM, A. et al. 1964. Ascending systems of catecholamine neurons from the lower brain stem. Acta Physiol. Scand. 62: 485-486.
23. TANDA, G. et al. 2005. Effects of 4′-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine. J. Pharmacol. Exp. Ther. 313: 613-620.
24. CHAO, M.V. 2003. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4: 299-309.
25. HYMAN, C. et al. 1991. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350: 230-232.
26. ALTAR, C.A. et al. 1992. Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo. Proc. Natl. Acad. Sci. USA 89: 11347-11351.
27. KLEIN, R.L. et al. 1999. Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer. Brain Res. 847: 314-320.
28. BACHIS, A., E.O. MAJOR & I. MOCCHETTI. 2003. Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. J. Neurosci. 23: 5715-5722.
29. GUSTAFSSON, E. et al. 2003. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. Eur. J. Neurosci. 17: 2667-2678.
30. 2+ homeostasis and rescues cortical neurons from apoptotic death. J. Neurosci. Res. 49: 600-607.
31. NOSHENY, R.L., I. MOCCHETTI & A. BACHIS. 2005. Brain-derived neurotrophic factor as a prototype neuroprotective factor against HIV-1-associated neuronal degeneration. Neurotox. Res. 8: 187-198.
32. BENNETT, B.A., D.E. RUSYNIAK & C.K. HOLLINGSWORTH. 1995. HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. Brain Res. 705: 168-176.
33. MELLI, G. et al. 2006. Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy. Brain 129: 1330-1338.
34. CANALS, J.M. et al. 2004. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease. J. Neurosci. 24: 7727-7739.
35. BACHIS, A. & I. MOCCHETTI. 2006. Semisynthetic sphingoglycolipid LIGA20 is neuroprotective against human immunodeficiency virus-gp120-mediated apoptosis. J. Neurosci. Res. 83: 890-896.
36. HAN, B.H. et al. 2000. BDNF blocks caspase-3 activation in neonatal hypoxiaischemia. Neurobiol. Dis. 7: 38-53.
37. DONZELLA, G.A. et al. 1998. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat. Med. 4: 72-77.
38. TOMAC, A. et al. 1995. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 273: 335-339.
39. BECK, K.D. et al. 1995. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 273: 289-290.
40. BILANG-BLEUEL, A. et al. 1997. Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. USA 94: 8818-8823.
41. SANDERS, V.J. et al. 2000. Fibroblast growth factor modulates HIV coreceptor CXCR4 expression by neural cells. HNRC Group. J. Neurosci. Res. 59: 671-679.
42. PAXINOS, G. & C. WATSON. 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press. Sydney.
43. PAXINOS, G. & K.B. FRANKLIN. 2001. The Mouse Brain in Stereotaxic Coordinates. Academic Press. San Diego, CA.
44. ACQUAS, E. et al. 2004. Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases. Neurotox. Res. 5: 605-615.
45. NOSHENY, R.L. et al. 2007. Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo. Eur. J. Neurosci. 25: 2275-2284.