Protective Effects of MnM2Py4P and Mn-Salen Against Small Bowel Ischemia/Reperfusion Injury in Rats Using an In Vivo and an Ex Vivo Electron Paramagnetic Resonance Technique With a Spin Probe

Transplantation Proceedings

Volumn 39, Issue 10, 2007, Pages 3002-3006

  Watanabe, T ^a   Owada, S ^a   Kobayashi, H P ^a   Kawakami, H ^b   Nagaoka, S ^b   Murakami, E ^c   Ishiuchi, A ^a   Enomoto, T ^a   Jinnouchi, Y ^a   Sakurai, J ^a   Tobe, N ^a   Koizumi, S ^a   Shimamura, T ^a   Asakura, T ^a   Nakano, H ^a   Otsubo, T ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN UNIVERSITY   (Japan)

^c Eikoukagaku Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

[5,10,15,20 TETRAKIS(N METHYL 2 PYRIDYL)PORPHINATO]MANGANESE; HYDROGEN PEROXIDE; HYDROPEROXIDE; HYDROXYL RADICAL; MANGANESE DERIVATIVE; MANGANESE N,N' BIS(SALICYLIDENE)ETHYLENEDIAMINE CHLORIDE; NITRIC OXIDE; OXYGEN; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; INTESTINE ISCHEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ETHYLENEDIAMINES; INTESTINE, SMALL; METALLOPORPHYRINS; RATS; REPERFUSION INJURY;

EID: 37049006935     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2007.08.091     Document Type: Article

References (12)

1. Dimitrios P., Ioanna A., Apostolos P., et al. Protective effect of a novel antioxidant non-steroidal anti-inflammatory agent (compound 1A) on intestinal viability after acute mesenteric ischemia and reperfusion. Eur J Pharmacol 465 (2003) 275
2. Yamato M., Egashira T., and Utsumi H. Application of in vivo ESR spectroscopy to the measurement of cerebrovascular ROS generation in stroke. Free Radic Biol Med 35 (2003) 1619
3. Samuni A., Krishna C., and Mitchell J. Superoxide reaction with nitroxides. Free Radic Res Commun 9 (1992) 241
4. Togashi H., Shinzawa H., and Matsuo T. Analysis of hepatic oxidative stress status by electron spin resonance spectroscopy and imaging. Free Radic Biol Med 28 (2000) 846
5. Couet W.R., Brasch R.C., Sosnovsky C., et al. Factors affecting nitroxide reduction in ascorbate solution and tissue homogenate. Magn Reson Imaging 3 (1985) 83
6. Gadzheva V., Ichimori K., and Nakazawa H. Superoxide scavenging activity of spin-labeled nitrosourea and triazene derivatives. Free Radic Res 3 (1994) 177
7. Batinic-Haberle I., Benov L., Spasojevic I., et al. The ortho effect makes manganese (III) meso-tetrakis (N-methylpyridinium-2-yl) porphyrin a powerful and potentially useful superoxide dismutase mimic. J Biol Chem 273 (1998) 24521
8. Boucher L.J. Manganese Schiff's base complexes II: synthesis and spectroscopy of chloro complexes of some derivatives of (salicylaldehydeethylenediimato)manganese(III). J Inorg Nucl Chem 36 (1974) 531
9. Baker K., Marcus C.B., Huffman K., et al. Synthetic combined superoxide dismutase/catalase mimics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284 (1998) 215
10. Sharpe M.A., Ollosson R., Stewart V.C., et al. Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics. Biochem J 366 (2002) 97
11. Yoshida M., Saegusa Y., Fukuda A., et al. Measurement of radical-scavenging ability in hepatic metallothionein of rat using in vivo electron spin resonance spectroscopy. Toxicology 213 (2005) 74
12. Udassin R., Haskel Y., and Samuni A. Nitroxide radical attenuates ischemia/reperfusion injury to the rat intestine. Gut 42 (1998) 621