An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 28, Issue 1, 2001, Pages 93-105

  Evans, N D ^a   Godfrey, K R ^a   Chapman, M J ^b   Chappell, M J ^a   Aarons, L ^c   Duffull, S B ^c  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b Faculty of Health and Life Sciences   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Compartmental models; Identification; Ivabradine; Linear systems; Pharmacokinetics

Indexed keywords

ANTIARRHYTHMIC AGENT; DRUG METABOLITE; IVABRADINE; S 18982; UNCLASSIFIED DRUG;

ARTICLE; DRUG BLOOD LEVEL; FIRST PASS EFFECT; HUMAN; LINEAR SYSTEM; MATHEMATICAL MODEL; PRIORITY JOURNAL;

EID: 36949036888     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011521819898     Document Type: Article

References (8)

1. A pharmacokinetic simulation model for ivabradine
2. Unidentifiable compartmental models: What to do?
3. Identifiability and indistinguishability of linear compartmental models
4. On structural equivalence and identifiability constraint ordering
5. On the structural controllability of compartmental systems
6. Controllability and observability of linear time invariant compartmental models