Antibodies to tissue transglutaminase: An immune link between the gut, the coronaries and the myocardium?

Journal of Internal Medicine

Volumn 263, Issue 1, 2008, Pages 1-3

  Sane, D C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1;

ANGIOGENESIS; ANTIBODY TITER; ATHEROSCLEROTIC PLAQUE; CELIAC DISEASE; EDITORIAL; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART FAILURE; HEART MUSCLE; HEART TRANSPLANTATION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; AUTOANTIBODIES; CELIAC DISEASE; CORONARY VESSELS; HUMANS; MYOCARDIUM; TRANSGLUTAMINASES;

EID: 36949028076     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2007.01882.x     Document Type: Editorial

References (23)

1. Dieterich W, Ehnis T, Bauer M et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997 3 : 797 801.
2. Hadithi M, von Blomberg ME, Crusius BA et al. Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease. Ann Intern Med 2007 147 : 294 302.
3. Di Tola M, Barillá F, Trappolini M, Palumbo HF, Gaudio C, Picarelli A. Anti-tissue transglutaminase antibodies in acute coronary syndrome: an alert signal of myocardial tissue lesion? J Intern Med 2007 263 : 43 51.
4. Peracchi M, Trovato C, Longhi M et al. Tissue transglutaminase antibodies in patients with end-stage heart failure. Am J Gastroenterol 2002 97 : 2850 4.
5. DeBem RS, Utiyama SR, Nisihara RM et al. Celiac disease prevalence in Brazilian dilated cardiomyopathy patients. Dig Dis Sci 2006 51 : 1016 9.
6. Curione M, Barbato M, De Biase L, Viola F, Lo Russo F, Cardi E. Prevalence of coeliac disease in idiopathic dilated cardiomyopathy. Lancet 1999 354 : 222 3.
7. Chimenti C, Pieroni M, Frustaci A. Celiac disease in idiopathic dilated cardiomyopathy. Ital Heart J 2001 2 : 658 9.
8. Not T, Faleschini E, Tommasini A et al. Celiac disesase in patients with sporadic and inherited cardiomyopathies and in their relatives. Eur Heart J 2003 24 : 1455 61.
9. Frustaci A, Cuoco L, Chimenti C et al. Celiac disease associated with autoimmune myocarditis. Circulation 2002 105 : 2611 8.
10. Collin P. Should adults be screened for celiac disease? What are the benefits and harms of screening? Gastroenterology 2005 128 : S104 8.
11. Greenberg CS, Birckbichler PJ, Rice RH. Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues. FASEB J 1991 5 : 3071 7.
12. Sane DC, Kontos JL, Greenberg CS. Role of transglutaminases in cardiac and vascular diseases. Front Biosci 2007 12 : 2530 45.
13. Haroon ZA, Wannenburg T, Gupta M, Greenberg CS, Wallin R, Sane DC. Localization of tissue transglutaminase in human carotid and coronary artery atherosclerosis: implications for plaque stability and progression. Lab Invest 2001 81 : 83 93.
14. Sumi Y, Inoue N, Azumi H et al. Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability. Atherosclerosis 2002 160 : 31 9.
15. Boisvert WA, Rose DM, Boullier A. Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size. Arterioscler Thromb Vasc Biol 2006 26 : 563 9.
16. Nakaoka H, Perez DM, Baek KJ et al. Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function. Science 1994 264 : 1593 6.
17. Iwai N, Shimoike H, Kinoshita M. Genes up-regulated in hypertrophied ventricle. Biochem Biophys Res Commun 1995 209 : 527 34.
18. Small K, Feng JF, Lorenz J et al. Cardiac specific overexpression of transglutaminase II (G(h)) results in a unique hypertrophy phenotype independent of phospholipase C activation. J Biol Chem 1999 274 : 21291 6.
19. Nunes I, Shapiro RL, Rifkin DB. Characterization of latent TGF-beta activation by murine peritoneal macrophages. J Immunol 1995 155 : 1450 9.
20. hin the failing human heart. Circulation 1996 94 : 718 26.
21. DePalma R, Del Galdo F, Abbate G et al. Patients with acute coronary syndrome show oligoclonal T-cell recruitment within unstable plaque: evidence for a local, intracoronary immunologic mechanism. Circulation 2006 113 : 640 6.
22. Fleckenstein B, Qiao SW, Larsen MR, Jung G, Roepstorff P, Sollid LM. Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides. J Biol Chem 2004 279 : 17607 16.
23. Király R, Vecsei Z, Deményi T, Korponay-Szabó IR, Fésüs L. Coeliac autoantibodies can enhance transamidating and inhibit GTPase activity of tissue transglutamninase: dependence on reaction environment and enzyme fitness. J Autoimmun 2006 26 : 278 87.