Enhancement of cellular binding efficiency and cytotoxicity using polyethylene glycol base triblock copolymeric nanoparticles for targeted drug delivery

Journal of Biomedical Materials Research - Part A

Volumn 84, Issue 1, 2008, Pages 273-280

  Yang, Jaemoon ^a   Cho, Eun Jin ^b   Seo, Sungbaek ^a   Lee, Jae Won ^a   Yoon, Ho Geun ^b   Suh, Jin Suck ^b   Huh, Yong Min ^b   Haam, Seungjoo ^a  

^a Yonsei University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Doxorubicin; Folate; Nanoparticle; Poly caprolactone diol; Polyethylene glycol

Indexed keywords

COPOLYMERS; DRUG DELIVERY; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; PRECIPITATION (CHEMICAL); TRANSMISSION ELECTRON MICROSCOPY;

DOXORUBICIN; FLUORESCENCIC MICROSCOPIC IMAGINGS; FOLATE (FA); NANOPRECIPITATION;

NANOPARTICLES;

ANTINEOPLASTIC AGENT; COPOLYMER; DOXORUBICIN; FOLATE RECEPTOR; FOLIC ACID; MACROGOL; NANOPARTICLE;

ARTICLE; CELL SELECTION; CELL SIZE; CELL STRUCTURE; COLLOID; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENCAPSULATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERIZATION; PRECIPITATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SUSTAINED RELEASE PREPARATION; TRANSMISSION ELECTRON MICROSCOPY; TURBIDITY;

CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHYSICAL; DRUG DELIVERY SYSTEMS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NANOPARTICLES; POLYETHYLENE GLYCOLS;

EID: 36949022497     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31312     Document Type: Article

References (29)

1. Wirth M, Fuchs A, Wolf M, Ertl B, Gabor F. Lectin-mediated drug targeting: Preparation, binding characteristics, and antiproliferative activity of wheat germ agglutinin conjugated doxorubicin on Caco-2 cells. Pharm Res 1998;15:1031-1037.
2. Cannizzaro SM, Padera RF, Langer R, Rogers RA, Black FE, Davies MC, Tendler SJB, Shakesheff KM. A novel biotinylated degradable polymer for cell-interactive applications. Biotechnol Bioeng 1998;58:529-535.
3. Lu Y, Sega E, Leamon CP, Low PS. Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential. Adv Drug Deliv Rev 2004;56:1161-1176.
4. Artemov D, Mori N, Ravi R, Bhujwalla ZM. Magnetic resonance molecular imaging of the HER-2/neu receptor. Cancer Res 2003;63:2723-2727.
5. Reddy JA, Low PS. Folate-mediated targeting of therapeutic and imaging agents to cancers. Crit Rev Ther Drug Carr Syst 1998;15:587-627.
6. Vyas SP, Singh A, Sihorkar V. Ligand-receptor mediated drug delivery: An emerging paradigm in cellular drug targeting. Crit Rev Ther Drug Carr Syst 2001;18:1-76.
7. Turek JJ, Leamon CP, Low PS. Endocytosis of folate-protein conjugates: Ultrastructural localization in KB cells. J Cell Sci 1993;106:423-430.
8. Coney LR, Tomaselti A, Carayannopoulas L, Frasca V, Kamen BA, Colnaught MI, Zurawski VRJ. Cloning of a tumor associated antigen: Mov 18 and Mov 19 antibodies recognize a folate-binding protein. Cancer Res 1991;51:6125-6132.
9. Lu Y, Low PS. Immunotherapy of folate receptor-expressing tumors: Review of recent advances and future prospects. J Control Release 2003;91:17-29.
10. Miotti S, Bagnoli M, Ottone F, Tomassetti A, Colnaghi MI, Canevari S. Simultaneous activity of two different mechanisms of folate transport in ovarian carcinoma cell lines. J Cell Biochem 1997;65:479-491.
11. Gabizon A, Horowitz A, Goren D. Targeting folate receptor with folate linked to extremities of poly(ethylene glycol) grafted liposomes in vitro studies. Bioconjug Chem 1999;10:289-298.
12. Aronov O, Horowitz A, Gabizon A, Gibson D. Folate-targeted PEG as a potential carrier for carboplatin analogs. Bioconjug Chem 2003;14:563-574.
13. Yoo HS, Park TG. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J Control Release 2004;96:273-283.
14. Domb AJ, Kost J, Wiseman DM. Handbook of Biodegradable Polymers. Amsterdam: Harwood Academic Publishers; 1997.
15. Delgado A, Evora C, Llabres M. Degradation of DL-PLA-methadone microspheres during in vitro release. Int J Pharm 1996;140:219-227.
16. Ahmed F, Discher DE. Self-porating polymersomes of PEG-PLA and PEG-PCL: Hydrolysis-triggered controlled release vesicles. J Control Release 2004;96:37-53.
17. Piao L, Dai Z, Deng M, Chen X, Jing X. Synthesis and characterization of PCL/PEG/PCL triblock copolymers by using calcium catalyst. Polymer 2003;44:2025-2031.
18. Maruyama K, Takahashi N, Tagawab T, Nagaikeb K, Iwatsuru M. Targeting efficiency of PEG-immunoliposome-conjugated antibodies at PEG terminals. Adv Drug Deliv Rev 1997;24:235-242.
19. Kataoka K, Nagasaki Y. Block copolymer micelles for drug delivery: Design, characterization and biological significance. Adv Drug Deliv Rev 2001;47:113-131.
20. Venkatraman SS, Jie P, Min F, Freddy BYC, Leong-Huat G. Micelle-like nanoparticles of PLA-PEG-PLA triblock copolymer as chemotherapeutic carrier. Int J Pharm 2005;298:219-232.
21. Hwang MJ, Suh JM, Bae YH, Kim SW, Jeong B. Caprolactonic Poloxamer Analog: PEG-PCL-PEG. Biomacromolecules 2005;6:885-890.
22. Park EK, Lee SB, Lee YM. Preparation and characterization of methoxy poly(ethylene glycol)/poly(e-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Biomaterials 2005;26:1053-1061.
23. Zhang Y, Zhuo R. Synthesis and in vitro drug release behavior of amphiphilictriblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone. Biomaterials 2005;26:6736-6742.
24. Hermanson GT. Bioconjugate Techniques. San Diego, CA: Academic press; 1996.
25. Bilati U, Doelker E. Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. Eur J Pharm Sci 2005;24:67-75.
26. Yoshimura T, Nyuta K, Esumi K. Zwitterionic heterogemini surfactants containing ammonium and carboxylate headgroups. I. Adsorption and micellization. Langmuir 2005;21:2682-2688.
27. Freshney RI. The Culture of Animal Cells: A Manual of Basic Technique. New York:Wiley; 1994.
28. Govender T, Stolnik S, Garnett M, Ilium L, Davis S. PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug. J Control Release 1999;57:171-185.
29. Graham NB. Poly(ethylene glycol) gels and drug delivery. In: Harris JM, editor. Poly (ethylene glycol) Chemistry. New York/London: Plenum Press; 1992. p 263-281.