Synthesis and biophysical studies of N2′-functionalized 2′-amino-α-L-LNA

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 10-12, 2007, Pages 1403-1405

  Kumar, T Santhosh ^a   Madsen, Andreas S ^a   Wengel, Jesper ^a   Hrdlicka, Patrick J ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF IDAHO   (United States)

Author keywords

2 Amino L LNA; Intercalation; Oligonucleotides; Pyrene

Indexed keywords

HEPTANE; INTERCALATING AGENT; LOCKED NUCLEIC ACID; NUCLEIC ACID; PHOSPHORAMIDIC ACID DERIVATIVE;

ACYLATION; ALKYLATION; ARTICLE; BIOPHYSICS; SYNTHESIS;

BICYCLO COMPOUNDS, HETEROCYCLIC; BIOPHYSICS; ORGANOPHOSPHORUS COMPOUNDS; THYMIDINE MONOPHOSPHATE;

EID: 36949019762     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701538841     Document Type: Article

References (6)

1. Wengel, J. Synthesis of 3′-C- and 4′-C-branched oligodeoxynucleotides and the development of locked nucleic acid (LNA). Accounts Chem. Res. 1999, 32, 301-310.
2. Singh, S.K.; Kumar, R.; Wengel, J. Synthesis of 2′-amino-LNA: A novel conformationally restricted high-affinity oligonucleotide analogue with a handle. J. Org. Chem. 1998, 63, 10035-10039.
3. Sørensen, M.D.; Kværnø, L.; Bryld, T.; Håkansson, A.E.; Verbeure, B.; Gaubert, G.; Herdewijn, P.; Wengel, J. α-L-ribo-Configured locked nucleic acid (α-L-LNA): Synthesis and properties. J. Am. Chem. Soc. 2002, 124, 2164-2176.
4. Kumar, T.S.; Madsen, A.S.; Wengel, J.; Hrdlicka, P.J. Synthesis and hybridization studies of 2′-amino-α-L-LNA and tetracyclic "Locked LNA." J. Org. Chem. 2006, 71, 4188-4201.
5. Hrdlicka, P.J.; Babu, B.R.; Sørensen, M.D.; Harrit, N.; Wengel, J. Multilabeled pyrene-functionalized 2′-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays. J. Am. Chem. Soc. 2005, 127, 13293-13299 and references cited therein.
6. Hrdlicka, P.J.; Kumar, T.S.; Wengel, J. Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2′-amino-α-L-LNA. Chem. Comm. 2005, 4279-4281.