Effect of simvastatin on insulin sensitivity in type 2 diabetic subjects

Pakistan Journal of Medical Sciences

Volumn 23, Issue 5, 2007, Pages 755-759

  Hydrie, M Zafar Iqbal ^a   Qasim, Rashida ^b   Ahmadani, M Yakoob ^a   Miyan, Zahid ^a   Fawwad, Asher ^a   Basit, Abdul ^a  

^a BAQAI MEDICAL UNIVERSITY   (Pakistan)

^b SINDH INSTITUTE OF UROLOGY AND TRANSPLANTATION   (Pakistan)

Author keywords

Diabetes; Insulin sensitivity; Lipid profile; Simvastatin

Indexed keywords

CREATININE; GLUCOSE; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; SIMVASTATIN;

ADULT; AGE DISTRIBUTION; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE DURATION; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PAKISTAN; RANDOMIZED CONTROLLED TRIAL;

EID: 36949016667     PISSN: 1682024X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. IDF Diabetes Atlas 2nd Edition, 2003. International Diabetes Federation, Brussels, 2003.
2. Reaven GM. Syndrome X: 6 years later. J Intern Med Suppl 1994;736:13-22.
3. Paolisso G, Sgambato S, De Riu S, Gambardella A, Verza M, Varricchio M, et al. Simvastatin reduces plasma lipid levels and improves insulin action in elderly, non insulin dependent diabetics. Eur J Clin Pharmacol 1991;40(1):27-31.
4. Paolisso G, Barbagallo M, Petrella G, Ragno E, Barbieri M, Giordano M, et al. Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients. Atherosclerosis 2000;150(1):121-7.
5. Stewart MW, Dyer RG, Alberti KGMM, Laker MF. The effects of lipid lowering drugs on metabolic control and lipoprotein composition in type 2 diabetic patients with mild hyperlipidemia. Diabetic Med 1995;12:250-7.
6. Hwu CM, Kwok CF, Chen HS, Shift KC, Lee SH, Hsiao LC, et al. Lack of effect of simvastatin on insulin sensitivity in type 2 diabetic patients with hypercholesterolamia: Results from a double-blind, randomized, placebo-controlled crossover study. Diabet Med 1999;16:749-54.
7. Farrer M, Winocour PH, Evans K, Neil HAW, Laker MF, Kesteven P, et al. Simvastatin in non-insulin-dependent diabetes mellitus: effect on serum lipids, lipoproteins and haemostatic measures. Diab Res Clin Pract1994;23:111-9.
8. Kazumi T, Yoshino G, Ohki A, Matsuba K, Ino T, Amano M, et al. Simvastatin Study Group. Long-term effects of simvastatin in hyper-cholesterolemic patients with NIDDM and additional atherosclerotic risk factors. Horm Metab Res1995;27:239-43.
9. Scandinavian Simvastatin Survival Study Group: Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;334:1383-9.
10. Shepard J, Cobbe SM, Ford I. The West of Scotland Coronary Prevention Study Group: prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 1995;333:1301-7.
11. Pyorala K, Pedersen TR, Kjekshus J. Scandinavian Simvastatin Survival Study (4S) Group. Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S). Diabetes Care 1997;20:614-20.
12. Matthews DR, Hosker JP, Rudenski AS. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentration. Diabetologia 1985;28:412-9.
13. Fukushima M, Taniguchi A, Sakai M. Assessment of insulin sensitivity: comparison between simplified evaluations and minimal model analysis. Diabetes Care 2000;23:1038-9.
14. Mather KJ, Hunt AE, Steinberg HO. Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab 2001;86:5457-64.
15. Ohrvall ML, Lithell H, Johansson J, Vessby B. A comparison between the effect of gemfibrozil and simvastatin on insulin sensitivity in patients with non-insulin dependent diabetes mellitus and hyperlipoproteinemia. Metabolism 1995;44:212-7.
16. Manolio TA, Savage PJ, Burke GL, Liu K, Wagneknecht LE, Sidney S, et al. Association of fasting insulin with blood pressure and lipid in young adults. Arteriosclerosis 1990;10:430-6.
17. Fontbonne A, Papoz L, Eschwege E, Roger M, Saint-Paul M, Simon D. Features of insulin-resistance syndrome in men from French Caribbean Islands. The Telecom Study. Diabetes 1992;41(11):1385-9.