Drug resistance in epilepsy: More twists in the tale [1]

Epilepsia

Volumn 48, Issue 12, 2007, Pages 2369-2370

  Sisodiya, Sanjay M ^a,b   Goldstein, David B ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b EPILEPSY SOCIETY   (United Kingdom)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; VERAPAMIL;

CLINICAL PRACTICE; DRUG SENSITIVITY; EPILEPSY; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; LETTER; PHARMACOGENOMICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ANTICONVULSANTS; DRUG RESISTANCE; EPILEPSY; GENOTYPE; HUMANS; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; VARIATION (GENETICS);

EID: 36949012486     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01260_1.x     Document Type: Letter

References (5)

1. Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, Calcagno AM, Ambudkar SV, Gottesman MM 2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 315 : 525 528.
2. Kwan P, Brodie MJ 2005) Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia 46 : 224 235.
3. Loscher W, Potschka H 2005) Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx 2 : 86 98.
4. Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM 2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 348 : 1442 1448.
5. Tan NC, Heron SE, Scheffer IE, Pelekanos JT, McMahon JM, Vears DF, Mulley JC, Berkovic SF 2004) Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy. Neurology 63 : 1090 1092.