5-Diacetoxymethyl-cycloSal-d4TMP - A prototype of enzymatically activated cyclosal-pronucleotides

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 6-7, 2007, Pages 861-864

  Gisch, N ^a   Balzarini, J ^b   Meier, C ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti HIV; Antiviral activity; CycloSal; Enzymatic activation; Pronucleotides

Indexed keywords

NUCLEOTIDE DERIVATIVE;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; ENZYME ACTIVATION; HUMAN IMMUNODEFICIENCY VIRUS; HYDROLYSIS;

ENZYMES; NUCLEOTIDES; PRODRUGS; STAVUDINE; THYMINE NUCLEOTIDES;

EID: 36949011400     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701504025     Document Type: Conference Paper

References (6)

1. Meier, C. cycloSal-pronucleotides-Design of chemical trojan horses. Mini Rev. Medicinal Chem. 2002, 2, 219-234.
2. Meier, C. cycloSal phosphates as chemical trojan horses for intracellular nucleotide and glycosylmonophosphate delivery-Chemistry meets biology. Eur. J. Organic Chem. 2006, 1081-1102.
3. Meier, C. 2004. cycloSal-Pronucleotides-Design of the concept, chemistry, and antiviral activity. In Advances in Antiviral Drug Design, Vol. 4, E. de Clercq, Ed. Elsevier, Amsterdam, pp. 147-213.
4. Meier, C.; Ruppel, M.F.H.; Vukadinovic, D.; Balzarini, J. Second generation of cycloSal-pronucleotides with esterase-cleavable sites: The "lock-in"-concept. Nucleosides, Nucleotides & Nucleic Acids 2004, 23, 89-115.
5. Meier, C.; Ducho, C.; Jessen, H.; Vukadinovi-Tenter, D.; Balzarini, J. Second-generation cycloSal-d4TMP pronucleotides bearing esterase-cleavable sites-The "trapping" concept. Eur. J. Organic Chem. 2006, 197-206.
6. Perigaud, C.; Gosselin, G.; Imbach, J.-L. Minireview: from the pronucleotide concept to the SATE phosphate protecting groups. Current Topics Med. Chem. 1997, 2, 15-29.