Reactions of malonaldehyde and acetaldehyde with calf thymus DNA: Formation of conjugate adducts

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 6-7, 2007, Pages 567-571

  Pluskota Karwatka, Donata ^a   Pawlowicz, Agnieszka J ^b   Kronberg, Leif ^b  

^a ADAM MICKIEWICZ UNIVERSITY   (Poland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

Acetaldehyde; DNA adducts; Endogenous mutagens; Malonaldehyde; Structural

Indexed keywords

2' DEOXYNUCLEOSIDE; ACETALDEHYDE; DNA; DOUBLE STRANDED DNA; GUANINE; MALONALDEHYDE; NUCLEOTIDE;

BIOSENSOR; CALF (BOVINE); CONFERENCE PAPER; CONJUGATION; ELUTION; FLUORESCENCE; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; STANDARD; THYMUS;

ACETALDEHYDE; ANIMALS; DNA; DNA ADDUCTS; HYDROLYSIS; MALONDIALDEHYDE;

EID: 36949009002     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701490100     Document Type: Conference Paper

References (10)

1. Esterbauer, H. Aldehydic products of lipid peroxidation. In Free Radicals, Lipid Peroxidation and Cancer, (eds. D. McBrien and T. Slater) Academic, New York. 1982, pp. 101-128.
2. Pryor, W.A.; Stanley, J.P. A suggested mechanism for the production of malondialdehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymatic production of prostaglandin endoperoxides during autoxidation. J. Org. Chem. 1975, 40, 3615-3617.
3. Marnett, L.J. Lipid peroxidation - DNA damage by malondialdehyde. Mutat. Res. 1999, 424, 83-95.
4. Vaca, C.E.; Fang, J-L.; Schweda, E.K.H. Studies of the reaction of acetaldehyde with nucleosides. Chem. Biol. Interact. 1995, 98, 51-67.
5. Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.W.; Hecht, S.S. Identification of DNA adducts of acetaldehyde. Chem. Res. Toxicol. 2000, 13, 1149-1157.
6. Gómez-Sánchez, A.; Hermosin, I.; Lassaletta, J-M.; Maya, I. Cleavage and oligomerization of malondialdehyde. Tetrahedron 1993, 49, 1237-1250.
7. Le Curieux, F.; Pluskota, D.; Munter, T.; Sjöholm, R.; Kronberg, L. Identification of fluorescent 2′-deoxyadenosine adducts formed in reactions of conjugates of malonaldehyde and acetaldehyde, and of malonaldehyde and formaldehyde. Chem. Res. Toxicol. 2000, 13, 1228-1234.
8. Pluskota-Karwatka, D.; Le Curieux, F.; Munter, T.; Sjöholm, R.; Kronberg, L. Identification of conjugate adducts formed in the reactions of malonaldehyde-acetaldehyde and malonaldehyde-formaldehyde with cytidine. Chem. Res. Toxicol. 2002, 15, 110-117.
9. Pluskota-Karwatka, D.; Le Curieux, F.; Munter, T.; Sjöholm, R.; Kronberg, L. Formation of conjugate adducts in the reactions of malonaldehyde-acetaldehyde and malonaldehyde-formaldehyde with guanosine. Chem. Res. Toxicol. 2005, 18, 300-307.
10. Munter, T.; Cottrell, L.; Hill, S.; Kronberg, L.; Watson, W.P.; Golding, B.T. Identification of adducts derived from reactions of (1-chloroethenyl) oxirane with nucleosides and calf thymus DNA. Chem. Res. Toxicol. 2002, 15, 1549-1560.