Anti-prolactin (PRL) autoantibodies suppress PRL bioactivity in patients with macroprolactinaemia

Clinical Endocrinology

Volumn 68, Issue 1, 2008, Pages 72-76

  Hattori, Naoki ^a   Nakayama, Yasuhisa ^a   Kitagawa, Kaori ^a   Ishihara, Takashi ^b   Saiki, Yasuhiko ^b   Inagaki, Chiyoko ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; HORMONE ANTIBODY; PROLACTIN; PROLACTIN ANTIBODY; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ADULT; ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; BIOASSAY; CANCER CELL; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INCUBATION TIME; LYMPHOMA CELL; MACROPROLACTINEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ADULT; ANIMALS; AUTOANTIBODIES; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MIDDLE AGED; PHOSPHORYLATION; PROLACTIN; PROLACTINOMA; RATS; STAT5 TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 36949003690     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.03001.x     Document Type: Article

References (19)

1. Leslie, H., Courtney, C.H., Bell, P.M., Hadden, D.R., McCance, D.R., Ellis, P.K., Sheridan, B. Atkinson, A.B. (2002) Laboratory and clinical experience in 55 patients with macroprolactinemia identified by a simple polyethylene glycol precipitation method. Journal of Clinical Endocrinology and Metabolism, 86, 2743 2746.
2. Vallette-Kasic, S., Morange-Ramos, I., Selim, A., Gunz, G., Morange, S., Enjalbert, A., Martin, P.M., Jaquet, P. Brue, T. (2002) Macroprolactinemia revisited: a study on 106 patients. Journal of Clinical Endocrinology and Metabolism, 87, 581 588.
3. Hattori, N. (2003) Macroprolactinemia: a new cause of hyperprolactinemia. Journal of Pharmacological Sciences, 92, 171 177.
4. Gibney, J., Smith, T.P. McKenna, T.J. (2005) Clinical relevance of macroprolactin. Clinical Endocrinology, 62, 633 643.
5. Hattori, N., Ishihara, T., Ikekubo, K., Moridera, K., Hino, M. Kurahachi, H. (1992) Autoantibody to human prolactin in patients with idiopathic hyperprolactinemia. Journal of Clinical Endocrinology and Metabolism, 75, 1226 1229.
6. Cavaco, B., Leite, V., Santos, M.A., Arranhado, E. Sobrinho, L.G. (1995) Some forms of big big prolactin behave as a complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactinemia or prolactinoma. Journal of Clinical Endocrinology and Metabolism, 80, 2342 2346.
7. Leanos-Miranda, A., Pascoe-Lira, D., Chavez-Rueda, K.A. Blanco-Favela, F. (2001) Persistence of macroprolactinemia due to antiprolactin autoantibody before, during, and after pregnancy in a woman with systemic lupus erythematosus. Journal of Clinical Endocrinology and Metabolism, 86, 2619 2624.
8. De Schepper, J., Schiettecatte, J., Velkeniers, B., Blumenfeld, Z., Shteinberg, M., Devroey, P., Anckaert, E., Smitz, J., Verdood, P., Hooghe, R. Hooghe-Peters, E. (2003) Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes. European Journal of Endocrinology, 149, 201 207.
9. Leite, V., Cosby, H., Sobrinho, L.G., Fresnoza, M.A., Santos, M.A. Friesen, H.G. (1992) Characterization of big, big prolactin in patients with hyperprolactinaemia. Clinical Endocrinology, 37, 365 372.
10. Strachan, M.W., Teoh, W.L., Don-Wauchope, A.C., Seth, J., Stoddart, M. Beckett, G.J. (2003) Clinical and radiological features of patients with macroprolactinaemia. Clinical Endocrinology, 59, 339 346.
11. Tanaka, T., Shiu, R.P., Gout, P.W., Beer, C.T., Noble, R.L. Friesen, H.G. (1980) A new sensitive and specific bioassay for lactogenic hormones: measurement of prolactin and growth hormone in human serum. Journal of Clinical Endocrinology and Metabolism, 51, 1058 1063.
12. Hattori, N. Inagaki, C. (1997) Anti-prolactin (PRL) autoantibodies cause asymptomatic hyperprolactinemia: bioassay and clearance studies of PRL-immunoglobulin G complex. Journal of Clinical Endocrinology and Metabolism, 82, 3107 3110.
13. Glezer, A., Soares, C.R., Vieira, J.G., Giannella-Neto, D., Ribela, M.T., Goffin, V. Bronstein, M.D. (2006) Human macroprolactin displays low biological activity via its homologous receptor in a new sensitive bioassay. Journal of Clinical Endocrinology and Metabolism, 91, 1048 1055.
14. Leanos-Miranda, A., Cardenas-Mondragon, G., Rivera-Leanos, R., Ulloa-Aguirre, A. Goffin, V. (2006) Application of new homologous in vitro bioassays for human lactogens to assess the actual bioactivity of human prolactin isoforms in hyperprolactinaemic patients. Clinical Endocrinology, 65, 146 153.
15. Jabbour, H.N., Critchley, H.O. Boddy, S.C. (1998) Expression of functional prolactin receptors in nonpregnant human endometrium: janus kinase-2, signal transducer and activator of transcription-1 (STAT1), and STAT5 proteins are phosphorylated after stimulation with prolactin. Journal of Clinical Endocrinology and Metabolism, 83, 2545 2553.
16. Kuzuya, H., Blix, P.M., Horwitz, D.L., Steiner, D.F. Rubenstein, A.H. (1977) Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes, 26, 22 29.
17. Baumann, G., Amburn, K. Shaw, M.A. (1988) The circulating growth hormone (GH)-binding protein complex: a major constituent of plasma GH in man. Endocrinology, 122, 976 984.
18. Hattori, N., Ikekubo, K., Nakayama, Y., Kitagawa, K. Inagaki, C. (2005) Immunoglobulin G subclasses and prolactin (PRL) isoforms in macroprolactinemia due to anti-PRL autoantibodies. Journal of Clinical Endocrinology and Metabolism, 90, 3036 3044.
19. Hattori, N., Nakayama, Y., Kitagawa, K., Ishihara, T., Saiki, Y. Inagaki, C. (2006) Anti-prolactin (PRL) autoantibody-binding sites (epitopes) on PRL molecule in macroprolactinemia. Journal of Endocrinology, 190, 287 293.