The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity

Journal of Biological Chemistry

Volumn 282, Issue 48, 2007, Pages 34984-34993

  Li, Jinliang ^a,d   Wei, Hong ^a   Chesley, Alan ^b   Moon, Chanil ^a   Krawczyk, Melissa ^a   Volkova, Maria ^a   Ziman, Bruce ^a   Margulies, Kenneth B ^c   Talan, Mark ^a   Crow, Michael T ^b   Boheler, Kenneth R ^a,d  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR SYSTEM; CELL PROLIFERATION; ENZYME INHIBITION; GROWTH KINETICS; NEONATAL MONITORING;

MYOCARDIAL INFARCTION; NEOVASCULOGENIC EFFECTS; PLEIOTROPHIN;

CELL DEATH;

PLEIOTROPHIN; PROTEIN KINASE B; SMALL INTERFERING RNA; SOMATOMEDIN C;

ADULT; AGED; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOMYOPATHY; CELL DIFFERENTIATION; CELL HYPOXIA; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; HEART INFARCTION; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEOMICS; RAT;

ANIMALS; ANOXIA; APOPTOSIS; CARRIER PROTEINS; CYTOKINES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

RATTUS;

EID: 36849080220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703513200     Document Type: Article

References (43)

1. Rauvala, H. (1989) EMBO J. 8, 2933-2941
2. Sato, M., Miyado, K., Okazaki, M., and Kimura, M. (1997) Biochem. Biophys. Res. Commun. 238, 831-837
3. Tezuka, K., Takeshita, S., Hakeda, Y., Kumegawa, M., Kikuno, R., and Hashimoto-Gotoh, T. (1990) Biochem. Biophys. Res. Commun. 173, 246-251
4. Fang, W., Hartmann, N., Chow, D. T., Riegel, A. T., and Wellstein, A. (1992) J. Biol. Chem. 267, 25889-25897
5. Deuel, T. F., Zhang, N., Yeh, H. J., Silos-Santiago, I., and Wang, Z. Y. (2002) Arch. Biochem. Biophys. 397, 162-171
6. Souttou, B., Raulais, D., and Vigny, M. (2001) J. Cell Physiol. 187, 59-64
7. Christman, K. L., Fang, Q., Kim, A. J., Sievers, R. E., Fok, H. H., Candia, A. F., Colley, K. J., Herradon, G., Ezquerra, L., Deuel, T. F., and Lee, R. J. (2005) Biochem. Biophys. Res. Commun. 332, 1146-1152
8. Choudhuri, R., Zhang, H. T., Donnini, S., Ziche, M., and Bicknell, R. (1997) Cancer Res. 57, 1814-1819
9. Bastias, J., Wei, M. X., Huynh, R., Chaubet, F., Jozefonvicz, J., and Crepin, M. (2002) Anticancer Res. 22, 1603-1613
10. Czubayko, F., Schulte, A. M., Berchem, G. J., and Wellstein, A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14753-14758
11. Riegel, A. T., and Wellstein, A. (1994) Breast Cancer Res. Treat. 31, 309-314
12. Wu, H., Barusevicius, A., Babb, J., Klein-Szanto, A., Godwin, A., Elenitsas, R., Gelfand, J. M., Lessin, S., and Seykora, J. T. (2005) J. Cutan. Pathol. 32, 125-130
13. Hampton, B. S., Marshak, D. R., and Burgess, W. H. (1992) Mol. Biol. Cell 3, 85-93
14. Yeh, H. J., He, Y. Y., Xu, J., Hsu, C. Y., and Deuel, T. F. (1998) J. Neurosci. 18, 3699-3707
15. Hida, H., Jung, C. G., Wu, C. Z., Kim, H. J., Kodama, Y., Masuda, T., and Nishino, H. (2003) Eur. J. Neurosci. 17, 2127-2134
16. Bowden, E. T., Stoica, G. E., and Wellstein, A. (2002) J. Biol. Chem. 277, 35862-35868
17. Maeda, N., Nishiwaki, T., Shintani, T., Hamanaka, H., and Noda, M. (1996) J. Biol. Chem. 271, 21446-21452
18. Milev, P., Chiba, A., Haring, M., Rauvala, H., Schachner, M., Ranscht, B., Margolis, R. K., and Margolis, R. U. (1998) J. Biol. Chem. 273, 6998-7005
19. Stoica, G. E., Kuo, A., Aigner, A., Sunitha, I., Souttou, B., Malerczyk, C., Caughey, D. J., Wen, D., Karavanov, A., Riegel, A. T., and Wellstein, A. (2001) J. Biol. Chem. 276, 16772-16779
20. Mitsiadis, T. A., Salmivirta, M., Muramatsu, T., Muramatsu, H., Rauvala, H., Lehtonen, E., Jalkanen, M., and Thesleff, I. (1995) Development (Camb.) 121, 37-51
21. Souttou, B., Ahmad, S., Riegel, A. T., and Wellstein, A. (1997) J. Biol. Chem. 272, 19588-19593
22. Powers, C., Aigner, A., Stoica, G. E., McDonnell, K., and Wellstein, A. (2002) J. Biol. Chem. 277, 14153-14158
23. Anisimov, S. V., Tarasov, K. V., Riordon, D., Wobus, A. M., and Boheler, K. R. (2002) Mech. Dev. 202, 25-74
24. Wang, D., Oparil, S., Feng, J. A., Li, P., Perry, G., Chen, L. B., Dai, M., John, S. W., and Chen, Y. F. (2003) Hypertension 42, 88-95
25. Margulies, K. B., Matiwala, S., Cornejo, C., Olsen, H., Craven, W. A., and Bednarik, D. (2005) Circ. Res. 96, 592-599
26. Christman, K. L., Fang, Q., Yee, M. S., Johnson, K. R., Sievers, R. E., and Lee, R. J. (2005) Biomaterials 26, 1139-1144
27. Chen, H. W., Yu, S. L., Chen, W. J., Yang, P. C., Chien, C. T., Chou, H. Y., Li, H. N., Peck, K., Huang, C. H., Lin, F. Y., Chen, J. J., and Lee, Y. T. (2004) Heart 90, 927-934
28. Boheler, K. R., Volkova, M., Morrell, C., Garg, R., Zhu, Y., Margulies, K., Seymour, A. M., and Lakatta, E. G. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2754-2759
29. Moon, C., Krawczyk, M., Ahn, D., Ahmet, I., Paik, D., Lakatta, E. G., and Talan, M. I. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11612-11617
30. Iwaki, K., Sukhatme, V. P., Shubeita, H. E., and Chien, K. R. (1990) J. Biol. Chem. 265, 13809-13817
31. Chesley, A., Lundberg, M. S., Asai, T., Xiao, R. P., Ohtani, S., Lakatta, E. G., and Crow, M. T. (2000) Circ. Res. 87, 1172-1179
32. Communal, C., Singh, K., Pimentel, D. R., and Colucci, W. S. (1998) Circulation 98, 1329-1334
33. Pufe, T., Bartscher, M., Petersen, W., Tillmann, B., and Mentlein, R. (2003) Arthritis Rheum. 48, 660-667
34. Taravini, I. R., Ferrario, J. E., Delbe, J., Ginestet, L., Debeir, T., Courty, J., Murer, M. G., Gershanik, O. S., and Raisman-Vozari, R. (2005) Brain Res. 1066, 196-200
35. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
36. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell 91, 231-241
37. Yin, H., Chao, L., and Chao, J. (2005) J. Biol. Chem. 280, 8022-8030
38. Bao, X., Mikami, T., Yamada, S., Faissner, A., Muramatsu, T., and Sugahara, K. (2005) J. Biol. Chem. 280, 9180-9191
39. Spinale, F. G., Zellner, J. L., Johnson, W. S., Eble, D. M., and Munyer, P. D. (1996) J. Mol. Cell. Cardiol. 28, 1591-1608
40. Chang, Y., Zuka, M., Perez-Pinera, P., Astudillo, A., Mortimer, J., Berenson, J. R., and Deuel, T. F. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 10888-10893
41. Bernard-Pierrot, I., Delbe, J., Rouet, V., Vigny, M., Kerros, M. E., Caruelle, D., Raulais, D., Barritault, D., Courty, J., and Milhiet, P. E. (2002) J. Biol. Chem. 277, 32071-32077
42. Li, J., Brown, L. F., Laham, R. J., Volk, R., and Simons, M. (1997) Circ. Res. 81, 785-796
43. Zhang, Y., Li, J., Partovian, C., Sellke, F. W., and Simons, M. (2003) Am. J. Physiol. 284, H2078-H2082