Acute antihypertensive action of Tempol in the spontaneously hypertensive rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 6, 2007, Pages

  Chen, Xueguang ^a   Patel, Kinjal ^a   Connors, Stephanie G ^a   Mendonca, Margarida ^a   Welch, William J ^a   Wilcox, Christopher S ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Adenosine 5 triphosphate activated potassium channels; Catalase; Nitric oxide synthase; Superoxide dismutase; Sympathetic nervous system

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMITROLE; BUTHIONINE SULFOXIMINE; CATALASE; GLUTATHIONE PEROXIDASE; HEME OXYGENASE; HYDROGEN PEROXIDE; IBERIOTOXIN; MESOPORPHYRIN TIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; POTASSIUM; TEMPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; HYPERTENSION; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; TREATMENT RESPONSE;

AMITROLE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; BUTHIONINE SULFOXIMINE; CATALASE; CROMAKALIM; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GANGLIONIC BLOCKERS; GLUTATHIONE PEROXIDASE; GLYBURIDE; HEART RATE; HEME OXYGENASE (DECYCLIZING); HEXAMETHONIUM; HYPERTENSION; INFUSIONS, INTRAVENOUS; KATP CHANNELS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; METALLOPORPHYRINS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, INBRED SHR; SPIN LABELS; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS;

EID: 36849072068     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00957.2007     Document Type: Article

References (53)

1. Bang L, Boesgaard S, Nielsen-Kudsk JE, Vejlstrup NG, Aldershvile J. Nitroglycerin-mediated vasorelaxation is modulated by endothelial calciuma-ctivated potassium channels. Cardiovasc Res 43: 772-778, 1999.
2. Barri YM, Limacher MC, Wilcox CS. Extreme blood pressure fluctuations in a patient with intact autonomic reflexes and intact sodium conservation. J Am Soc Nephrol 6: 347-353, 1995.
3. Burgdorf C, Dendorfer A, Kurz T, Schomig E, Stolting I, Schutte F, Richardt G. Role of neuronal KATP channels and extraneuronal mono-amine transporter on norepinephrine overflow in a model of myocardial low flow ischemia. J Pharmacol Exp Ther 309: 42-48, 2004.
4. Campese VM, Ye S, Zhong H, Yanamadala V, Ye Z, Chiu J. Reactive oxygen species stimulate central and peripheral sympathetic nervous system activity. Am J Physiol Heart Circ Physiol 287: H695-H703, 2004.
5. Cavero I, Mondot S, Mestre M. Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels. J Pharmacol Exp Ther 248: 1261-1268, 1989.
6. Coetzee WA, Nakamura TY, Faivre JF. Effects of thiol-modifying agents on KATP channels in guinea pig ventricular cells. Am J Physiol Heart Circ Physiol 269: H1625-H1633, 1995.
7. Cuzzocrea S, McDonald MC, Mazzon E, Siriwardena D, Costantino G, Fulia F, Cucinotta G, Gitto E, Cordaro S, Barberi I, De SA, Caputi AP, Thiemermann C. Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury. Brain Res 875: 96-106, 2000.
8. De Richelieu LT, Sorensen CM, Holstein-Rathlou NH, Salomonsson M. NO-independent mechanism mediates tempol-induced renal vasodilation in SHR. Am J Physiol Renal Physiol 289: F1227-F1234, 2005.
9. + channel in rat brain. Brain Res 814: 41-54, 1998.
10. Gao H, Peng B, Welch WJ, Wilcox CS. Central thromboxane receptors: mRNA expression and mediation of pressor responses. Am J Physiol Regul Integr Comp Physiol 272: R1493-R1500, 1997.
11. Gelvan D, Saltman P, Powell SR. Cardiac reperfusion damage prevented by a nitroxide free radical. Proc Natl Acad Sci USA 88: 4680-4684, 1991.
12. Goldhaber JI, Weiss JN. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension 20: 118-127, 1992.
13. ATP channel by redox agents. Biochim Biophys Acta 1410: 91-96, 1999.
14. Herrera GM, Resta TC, Candelaria JJ, Walker BR. Maintained vasodilatory response to cromakalim after inhibition of nitric oxide synthesis. J Cardiovasc Pharmacol 31: 921-929, 1998.
15. + channels in rat aorta and brain microvascular endothelial cells. Am J Physiol Cell Physiol 265: C812-C821, 1993.
16. Kaiser L. Adjusting for baseline: change or percentage change? Stat Med 8: 1183-1190, 1989.
17. Katnik C, Adams DJ. An ATP-sensitive potassium conductance in rabbit arterial endothelial cells. J Physiol 485: 595-606, 1995.
18. Katnik C, Adams DJ. Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells. Am J Physiol Heart Circ Physiol 272: H2507-H2511, 1997.
19. Kingma JG Jr, Simard D, Rouleau JR, Tanguay RM, Currie RW. Effect of 3-aminotriazole on hyperthermia-mediated cardioprotection in rabbits. Am J Physiol Heart Circ Physiol 270: H1165-H1171, 1996.
20. Kopkan L, Majid DS. Enhanced superoxide activity modulates renal function in NO-deficient hypertensive rats. Hypertension 47: 568-572, 2006.
21. +-channel currents of pancreatic beta-cells. Biochem Biophys Res Commun 200: 860-866, 1994.
22. Krishna CM, Samuni A, Taira J, Goldstein S, Mitchell JB, Russo A. Stimulation by nitroxides of catalase-like activity of hemeproteins. J Biol Chem 271: 26018-26025, 1996.
23. •- or as SOD mimics? J Biol Chem 271: 26026-26031, 1996.
24. Liu Y, Gutterman DD. Oxidative stress and potassium channel function. Clin Exp Pharmacol Physiol 29: 305-311, 2002.
25. Lucchesi PA, Belmadani S, Matrougui K. Hydrogen peroxide acts as both vasodilator and vasoconstrictor in the control of perfused mouse mesenteric resistance arteries. J Hypertens 23: 571-579, 2005.
26. Luckhoff A, Busse R. Activators of potassium channels enhance calcium influx into endothelial cells as a consequence of potassium currents. Naunyn Schmiedebergs Arch Pharmacol 342: 94-99, 1990.
27. Luckhoff A, Busse R. Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential. Pflúgers Arch 416: 305-311, 1990.
28. Ca channels are not activated in vivo under resting conditions and during agonist stimulation. Am J Physiol Regul Integr Comp Physiol 292: R345-R353, 2007.
29. Mann SJ. Hypertensive Emergencies. In: Therapy in Nephrology and Hypertension, edited by Brady HR and Wilcox CS. Philadelphia, PA: Saunders, 2003, p. 569-579.
30. McDonald MC, Zacharowski K, Bowes J, Cuzzocrea S, Thiemermann C. Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion. Free Radic Biol Med 27: 493-503, 1999.
31. Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, Gutterman DD. Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. Circ Res 92: e31-e40, 2003.
32. Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M. Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci USA 88: 10045-10048, 1991.
33. Nishiyama A, Fukui T, Fujisawa Y, Rahman M, Tian RX, Kimura S, Youichi A. Systemic and regional hemodynamic responses to tempol in angiotensin II-infused hypertensive rats. Hypertension 37: 77-83, 2001.
34. +-channel activators and inhibitors in guinea pig and human isolated right atrium. Cardiovasc Res 43: 125-134, 1999.
35. Patel K, Chen Y, Dennehy K, Blau J, Mendonca M, Tarpey M, Krishna M, Mitchell JB, Welch WJ, Wilcox CS. Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol 290: R37-R43, 2006.
36. + channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide. J Pharmacol Exp Ther 250: 261-271, 1989.
37. Rodriguez F, Zhang F, Dinocca S, Nasjletti A. Nitric oxide synthesis influences the renal vascular response to heme oxygenase inhibition. Am J Physiol Renal Physiol 284: F1255-F1262, 2003.
38. Samaha FF, Heineman FW, Ince C, Fleming J, Balaban RS. ATPsensitive potassium channel is essential to maintain basal coronary vascular tone in vivo. Am J Physiol Cell Physiol 262: C1220-C1227, 1992.
39. Schnackenberg CG, Welch WJ, Wilcox CS. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension 32: 59-64, 1998.
40. Shokoji T, Nishiyama A, Fujisawa Y, Hitomi H, Kiyomoto H, Takahashi N, Kimura S, Kohno M, Abe Y. Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats. Hypertension 41: 266-273, 2003.
41. Thakali K, Demel SL, Fink GD, Watts SW. Endothelin-1-induced contraction in veins is independent of hydrogen peroxide. Am J Physiol Heart Circ Physiol 289: H1115-H1122, 2005.
42. Thengchaisri N, Kuo L. Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels. Am J Physiol Heart Circ Physiol 285: H2255-H2263, 2003.
43. +-channels of skeletal muscle fibers from young adult and aged rats: possible involvement of thiol-dependent redox mechanisms in the age-related modifications of their biophysical and pharmacological properties. Mol Pharmacol 46: 754-761, 1994.
44. Vaziri ND, Wang XQ, Oveisi F, Rad B. Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats. Hypertension 36: 142-146, 2000.
45. Welch WJ, Mendonca M, Blau J, Karber A, Dennehy K, Lao Y, José P, Wilcox CS. Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat. Kidney Int 68: 179-187, 2005.
46. Wilcox CS. Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension. Am J Physiol Regul Integr Comp Physiol 289: R913-R935, 2005.
47. Xu H, Bian X, Watts SW, Hlavacova A. Activation of vascular BK channel by tempol in DOCA-salt hypertensive rats. Hypertension 46: 1154-1162, 2005.
48. Xu H, Fink GD, Galligan JJ. Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats. Am J Physiol Heart Circ Physiol 283: H885-H892, 2002.
49. •- in DOCA-salt rats. Hypertension 43: 329-334, 2004.
50. Xu H, Jackson WF, Fink GD, Galligan JJ. Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats. Hypertension 48: 1080-1087, 2006.
51. Ye S, Zhong H, Campese VM. Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension. Hypertension 48: 309-315, 2006.
52. Zhang Z, Rhinehart K, Solis G, Pittner J, Kwon W, Welch WJ, Wilcox CS, Pallone TL. Chronic ANG II infusion increases NO generation by rat descending vasa recta. Am J Physiol Heart Circ Physiol 288: H29-H36, 2005.
53. Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, Spitz DR, Davisson RL. Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res 91: 1038-1045, 2002.