Genotoxic effects of tanshinones from Hyptis martiusii in V79 cell line

Food and Chemical Toxicology

Volumn 46, Issue 1, 2008, Pages 388-392

  Cavalcanti, B C ^a   Moura, D J ^b   Rosa, R M ^b   Moraes, M O ^a   Araujo, E C C ^a   Lima, M A S ^a   Silveira, E R ^a   Saffi, J ^c   Henriques, J A P ^b,c   Pessoa, C ^a   Costa Lotufo, L V ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

Comet assay; Hyptis martiusii; Micronucleus test; Plant diterpene; Tanshinones

Indexed keywords

7ALPHA ACETOXY 12 HYDROXY 11,14 DIOXOABIETA 8,12 DIENE; 7BETA HYDROXY 11,14 DIOXOABIETA 8,13 DIENE; TANSHINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CHEMICAL STRUCTURE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; HYPTIS; HYPTIS MARTIUSII; IN VITRO STUDY; MICRONUCLEUS TEST; NONHUMAN;

ANIMALS; ANTIOXIDANTS; BLOOD CHEMICAL ANALYSIS; CARBON TETRACHLORIDE POISONING; CATALASE; FATTY LIVER; FLAVONOIDS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEPATITIS, TOXIC; HEPATOCYTES; LIPID PEROXIDATION; LIVER; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

CRICETULUS GRISEUS; HYPTIS; LAMIACEAE;

EID: 36849070368     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.08.009     Document Type: Article

References (40)

1. Akerele O. Summary of WHO guidelines for the assessment of herbal medicines. HerbalGram 28 (1993) 13-19
2. Araújo E.C.C., Lima M.A.S., Montenegro R.C., Nogueira M., Costa-Lotufo L.V., Pessoa C., Moraes M.O., and Silveira E.R. Cytotoxic abietane diterpenes from Hyptis martiusii Benth. Z. Naturforsch. C 61 (2006) 177-183
3. Bonacker D., Stoiber T., Wang M., Bohm K.J., Prots I., Unger E., Their R., Bolt H.M., and Degen G.H. Genotoxicity of inorganic mercury salts based on disturbed microtubule function. Arch. Toxicol. 78 (2004) 575-583
4. Cao E.H., Liu X.Q., Wang J.J., and Xu N.F. Effects of natural antioxidant tanshinone IIA on DNA damage by lipid peroxidation in liver cells. Free Rad. Biol. Med. 20 (1996) 801-806
5. Cardenas J., and Rodriguez-Hanh L. Abietane and icetexane diterpenoids from Salvia candicans. Phytochemistry 38 (1995) 199-204
6. Chen X., Ding J., YE Y., and Zhang J. Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis. J. Nat. Prod. 65 (2002) 1016-1020
7. Collins A.R. The comet assay for DNA damage and repair. Mol. Biotechnol. 26 (2004) 249-261
8. Collins A., Ai-guo M., and Duthie S.J. The kinetics of repair of oxidative DNA damage (strand breaks and oxidized pyrimidines) in human cells. Mutat. Res. 336 (1995) 69-77
9. Collins A., Duinská M., Franklin M., Somorovská M., Petrovská H., Duthie S., Fillion L., Panayiotidis M., Ralová K., and Vaughan N. Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ. Mol. Mutagen. 30 (1997) 139-146
10. Costa-Lotufo L., Araujo E.C.C., Lima M.A.S., Moraes M.E.A., Pessoa C., Silveira E.R., and Moraes M.O. Antiproliferative effects of abietane diterpenoids isolated from Hyptis martiusii Benth (Labiatae). Pharmazie 59 (2004) 78-79
11. Du J.R., Li X., Zhang R., and Qian Z.M. Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice. J. Ethnopharmacol. 98 (2005) 319-322
12. Fenech M. The in vitro micronucleus technique. Mutat. Res. (2000) 81-95
13. Hartmann A., and Speit G. The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay). Toxicol. Lett. 90 (1997) 183-188
14. Hartmann A., Plappert U., Poetter F., and Sutter W. Comparative study with the alkaline comet assay and the chromosome aberration test. Mutat. Res. 536 (2003) 27-38
15. Ikeshiro Y., Mase I., and Tomita Y. Abietane type diterpenes from Salvia miltiorrhiza. Phytochemistry 28 (1989) 3139-3141
16. Jimenez R., Portugal M.E., Lira-Rocha A., Soriano-Garcia M., and Toscano R.A. A new royleanone-type diterpene from Salvia sessei. J. Nat. Prod. 51 (1988) 243-248
17. Karmin O., Cheung F., Sung F.L., Zhu D.Y., and Siow Y.L. Effect of magnesium tanshinoate B on the production of nitric oxide in endothelial cells. Mol. Cell. Biochem. 207 (2000) 35-39
18. Kelecon A., and Santos T.C. Cariocal, a new seco-abietane diterpene from the Labiatae Coleus barbatus. Tetrahedron Lett. 26 (1985) 3659-3662
19. Kohli E., Raj H.G., Kumari R., Rohil V., Kaushik N.K., and Prasad A.K. Comparison of the prevention of aflotoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. Bioorg. Med. Chem. Lett. 12 (2002) 2579-2582
20. Lee A., Wu W., Chang W., Lin H., and King M. Isolation and bioactivity of new tanshinones. J. Nat. Prod. 50 (1987) 157-160
21. Lohman P.H.M., Gentile J.M., Gentile G., and Ferguson L.R. Antimutagenesis/anticarcinogenesis 2001: screening,methods and biomarkers. Mutat. Res. 496 (2001) 1-4
22. Marques S., Oliveira N.G., Chaveca T., and Rueff J. Micronuclei and sister chromatid exchanges induced by capsaicin in human lymphocytes. Mutat. Res. 517 (2002) 39-46
23. Matsuoka A., Yamazaki N., Suzuki T., Hayashi M., and Sofuni T. Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutat. Res. 272 (1992) 223-236
24. Mehrotra R., Vishwakarma R.A., and Thakur R.S. Abietane diterpenoids from Coleus zeylanicus. Phytochemistry 28 (1989) 3135-3137
25. Mosaddik M.A. In vitro cytotoxicity of Tanshinones isolated from Salvia miltiorrhiza Bunge against P388 lymphocytic leukemia cells. Phytomedicine 10 (2003) 682-685
26. Ng T.B., Liu F., and Wang Z.T. Antioxidative activity of natural products from plants. Life Sci. 66 (2000) 709-723
27. Sairafianpour M., Christensen J., Staerk D., Budnik B.A., Kharazmi A., Bagherzadeh K., and Jaroszewski J.W. Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones. J. Nat. Prod. 64 (2001) 1398-1403
28. Sato M., Sato T., Ose Y., Nagase H., Kito H., and Sakai Y. Modulating effect of tanshinones on mutagenic activity of Trp-P-1 and benzo [α] pyrene in Salmonella typhimurium. Mutat. Res. 256 (1992) 149-154
29. Silva L.D., Gaspar J., da Costa G.G., Rodrigues A.S., Laires A., and Rueff J. Chemical features of flavonols affecting their genotoxicity. Potentials implications in their use as therapeutical agents. Chem. Biol. Interact. 124 (2000) 29-51
30. Silva J., Freitas T.R.O., Heuser V., Marinho J.R., and Erdtmann B. Genotoxicity biomonitoring in coal regions using wilf rodent Ctenomys torquatus by Comet assay and Micronucleus test. Environ. Mol. Mutagen. 35 (2000) 270-278
31. Singh N.P., McCoy M.T., Tice R.R., and Scheider E.L. A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-191
32. Skibola C.F., and Smith M.T. Potential health impacts of excessive flavonoid intake. Free Radic. Biol. Med. 29 (2000) 375-383
33. Speit G., Habermeier B., and Helbig R. Differences in the response to mutagens between two V79 sublines. Mutat. Res. 325 (1994) 105-111
34. Takahashi K., Ouyang X., Komatsu K., Nakamura N., Hattori M., Baba A., and Azuma J. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem. Pharmacol. 64 (2002) 745-749
35. Tan N., Kaloga M., Radtke A.O., Kiderlen A.F., Oksuz S., Ulubelen A., and Kolodziej H. Abietane diterpenoids and tritepenoids acids from Salvia cilicica and their antileishmanial activities. Phytochemistry 61 (2002) 881-884
36. Ulubelen A., Topcu G., and Johansson C.B. Norditerpenoids and diterpenoids from Salvia multicalis with antituberculous activity. J. Nat. Prod. 60 (1997) 1275-1280
37. Wu T.W., Zeng L.H., and Fung K.P. Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells. Biochem. Pharmacol. 12 (1993) 2327-2332
38. Yagi A., and Takeo S. Anti-inflamatory constituents, aloesin and aloemannan in Aloe species and effects of tanshinone VI in Salvia miltiorrhiza on heart. Yakugaku Zasshi 123 (2003) 517-532
39. Yagi A., Fujimoto K., and Tanonaka K. Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements. Planta Med. 55 (1989) 51-54
40. Zhang K., Bao Y., Wu P., Rosen R.T., and Ho C. Antioxidative components of Tanshen (Salvia multiorrhiza Bung). J. Agric. Food Chem. 38 (1990) 1194-1197