The support-on-support concept for in-situ oligonucleotide synthesis on nanoparticles

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 8-9, 2007, Pages 1167-1172

  Seliger, H ^a   Hinz, M ^a   Ditz, R ^b   Koch, M ^b   Lapido, P ^c   Margel, S ^c  

^a UNIVERSITY OF ULM   (Germany)

^b MERCK KGAA   (Germany)

^c BAR ILAN UNIVERSITY   (Israel)

Author keywords

In situ synthesis; Nanoparticles; Oligonucleotide; Support on support concept

Indexed keywords

ALKALI; DEXTRAN; GELATIN; NANOPARTICLE; OLIGONUCLEOTIDE; POLYSTYRENE; PROTEINASE; SILICON DIOXIDE;

ARTICLE; AUTOMATION; NUCLEOTIDE METABOLISM;

DEXTRANS; FERROSOFERRIC OXIDE; METAL NANOPARTICLES; NANOPARTICLES; NANOTECHNOLOGY; OLIGODEOXYRIBONUCLEOTIDES; POLYHYDROXYETHYL METHACRYLATE; POLYSTYRENES; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 36849060513     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701527190     Document Type: Article

References (4)

1. Salata, O.V. Applications of nanoparticles in biology and medicine. J. Nanobiotechnol. 2004, 2, 3-8.
2. For earlier work on irreversibly linked core-shell particles: Seliger, H.; Hinz, M.; Gura, S.; Nitzan, B.; Margel, S. Solid-supported oligonucleotide systems for special biomedical applications. Nucleosides & Nucleotides 1999, 18, 1305-1307.
3. Kumar, P.; Sharma, A.K.; Gupta, K.C.; Margel, S.; Gura, S.; Seliger, H. Composite magnetic and non-magnetic beads as efficient solid supports for machine-aided oligonucleotide synthesis. Helv. Chim. Acta. 2001, 84, 345-350.
4. Recent report on reversible binding of nano- to microparticles, however, not for application to oligonucleotide synthesis: Abed, O.; Vaskevich, A.; Arad-Yelin, R.; Shanzer, A.; Rubinstein, J. Preparative manipulation of gold nanoparticles by reversible binding to a polymeric solid support. Chem. Eur. J. 2005, 11, 2836-2841.