Synthesis of anthraquinone oligonucleotides for triplex stabilization

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 8-9, 2007, Pages 921-925

  Zhao, Zhengyun ^a   Peng, Guomei ^a   Michels, Jan ^b   Fox, Keith R ^a   Brown, Tom ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Anthraquinone; Fluorescence quenchers; Triplex stabilizers

Indexed keywords

ANTHRAQUINONE DERIVATIVE; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; URACIL;

ARTICLE; CHEMICAL STRUCTURE; FLUORESCENCE; SYNTHESIS;

ANTHRAQUINONES; BASE SEQUENCE; DRUG DESIGN; DRUG STABILITY; FLUORESCENCE; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES;

EID: 36849056012     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701506491     Document Type: Article

References (5)

1. Felsenfeld, G.; Davies, D.R.; Rich, A. Formation of a three-stranded polynucleotide molecule. J. Am Chem. Soc. 1957, 2023-2024.
2. Huang, H.-S.; Chiu, H.-F.; Yeh, P.-F.; Yuan, C.-L. Structure-based design and synthesis of regioisomeric disubstituted aminoanthraquinone derivatives as potential anticancer agents. Helv. Chim. Acta 2004, 87, 999-1006.
3. Zafrul Azam, A.; Moriguchi, T.; Shinozuka, K. Modified α-β chimeric oligoDNA bearing a multiconjugate of 2,2-bis(hydroxymethyl) propionic acid-anthraquinone-polyamine exhibited improved and stereo-non-specific triplex-forming ability. Chem. Commun. 2006, 335-337.
4. May, J.P.; Brown, L.J.; van Delft, I.; Thelwell, N.; Harley, K.; Brown, T. Synthesis and evaluation of a new non-fluorescent quencher in fluorogenic oligonucleotide probes for real-time PCR. Org. Biomol. Chem. 2005, 3, 2534-2542.
5. Darby, R.A.J.; Sollogoub, M.; McKeen, C.; Brown, L.; Risitano, A.; Brown, N.; Barton, C.; Brown, T.; Fox, K.R. High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler. Nucleic Acids Res. 2002, 30, e39.