Microalbuminuria in Type 2 diabetes indicates impaired microvascular vasomotion and perfusion

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 6, 2007, Pages

  Schmiedel, Ole ^a,c   Schroeter, Matthias L ^b   Harvey, John N ^a  

^a WREXHAM MAELOR HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Diabetes mellitus; Laser Doppler flowmetry; Microcirculation; Physiopathology

Indexed keywords

ACETYLCHOLINESTERASE; C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; NITROPRUSSIDE SODIUM; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW MEASUREMENT; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; IONTOPHORESIS; LIPID METABOLISM; MICROALBUMINURIA; MICROCIRCULATION; MICROVASCULATURE; NON INSULIN DEPENDENT DIABETES MELLITUS; PERFUSION; PRIORITY JOURNAL; SPECTROSCOPY; VASOCONSTRICTION; VASODILATATION;

ACETYLCHOLINE; ADMINISTRATION, CUTANEOUS; AGED; ALBUMINURIA; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; ENDOTHELIUM, VASCULAR; HEAT; HUMANS; IONTOPHORESIS; LASER-DOPPLER FLOWMETRY; MICROCIRCULATION; MIDDLE AGED; MODELS, CARDIOVASCULAR; MULTIVARIATE ANALYSIS; NITROPRUSSIDE; PEDIGREE; REGIONAL BLOOD FLOW; SKIN; VASODILATION; VASODILATOR AGENTS;

EID: 36849055218     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00558.2007     Document Type: Article

References (36)

1. Arnlov J, Evans JC, Meigs JB, Wang TJ, Fox CS, Levy D, Benjamin EJ, D'Agostino RB, Vasan RS. Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study. Circulation 112: 969-975, 2005.
2. Benbow SJ, Pryce DW, Noblett K, MacFarlane IA, Friedmann PS, Williams G. Flow motion in peripheral diabetic neuropathy. Clin Sci (Lond) 88: 191-196, 1995.
3. Beny JL, Koenigsberger M, Sauser R. Role of myoendothelial communication on arterial vasomotion. Am J Physiol Heart Circ Physiol 291: H2036-H2038, 2006.
4. Bernardi L, Radaelli A, Solda PL, Coats AJ, Reeder M, Calciati A, Garrard CS, Sleight P. Autonomic control of skin microvessels: assessment by power spectrum of photoplethysmographic waves. Clin Sci (Lond) 90: 345-355, 1996.
5. Bernardi L, Rossi M, Leuzzi S, Mevio E, Fornasari G, Calciati A, Orlandi C, Fratino P. Reduction of 0.1 Hz microcirculatory fluctuations as evidence of sympathetic dysfunction in insulin-dependent diabetes. Cardiovasc Res 34: 185-191, 1997.
6. Braverman IM. The cutaneous microcirculation. J Invest Dermatol Symp Proc 5: 3-9, 2000.
7. Buerk DG, Riva CE. Vasomotion and spontaneous low-frequency oscillations in blood flow and nitric oxide in cat optic nerve head. Microvasc Res 55: 103-112, 1998.
8. Burnstock G, Ralevic V. New insights into the local regulation of blood flow by perivascular nerves and endothelium. Br J Plast Surg 47: 527-543, 1994.
9. Carr RT, Geddes JB, Wu F. Oscillations in a simple microvascular network. Ann Biomed Eng 33: 764-771, 2005.
10. Chen H, Sullivan G, Yue LQ, Katz A, Quon MJ. QUICKI is a useful index of insulin sensitivity in subjects with hypertension. Am J Physiol Endocrinol Metab 284: E804-E812, 2003.
11. Donnelly R, Yeung JM, Manning G. Microalbuminuria: a common, independent cardiovascular risk factor, especially but not exclusively in type 2 diabetes. J Hypertens Suppl 21: S7-S12, 2003.
12. Gooding KM, Hannemann MM, Tooke JE, Clough GF, Shore AC. Maximum skin hyperaemia induced by local heating: possible mechanisms. J Vasc Res 43: 270-277, 2006.
13. Intaglietta M. Arteriolar vasomotion: implications for tissue ischemia. Blood Vessels 28, Suppl 1: 1-7, 1991.
14. Jaap AJ, Hammersley MS, Shore AC, Tooke JE. Reduced microvascular hyperaemia in subjects at risk of developing type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 37: 214-216, 1994.
15. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85: 2402-2410, 2000.
16. Kvandal P, Landsverk SA, Bernjak A, Stefanovska A, Kvernmo HD, Kirkeboen KA. Low-frequency oscillations of the laser Doppler perfusion signal in human skin. Microvasc Res 2006.
17. Kvandal P, Stefanovska A, Veber M, Kvernmo HD, Kirkeboen KA. Regulation of human cutaneous circulation evaluated by laser Doppler flowmetry, iontophoresis, and spectral analysis: importance of nitric oxide and prostaglandines. Microvasc Res 65: 160-171, 2003.
18. Kvernmo HD, Stefanovska A, Kirkeboen KA, Kvernebo K. Oscillations in the human cutaneous blood perfusion signal modified by endothelium-dependent and endothelium-independent vasodilators. Microvasc Res 57: 298-309, 1999.
19. Medow MS, Minson CT, Stewart JM. Decreased microvascular nitric oxide-dependent vasodilation in postural tachycardia syndrome. Circulation 112: 2611-2618, 2005.
20. Meyer MF, Rose CJ, Hülsmann JO, Schatz H, Pfohl M. Impaired 0.1-Hz vasomotion assessed by laser Doppler anemometry as an early index of peripheral sympathetic neuropathy in diabetes. Microvasc Res 65: 88-95, 2003.
21. Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol 91: 1619-1626, 2001.
22. Morris SJ, Shore AC, Tooke JE. Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM. Diabetologia 38: 1337-1344, 1995.
23. Nilsson H, Aalkjaer C. Vasomotion: mechanisms and physiological importance. Mol Interv 3: 79-89, 2003.
24. Nuzzaci G, Evangelisti A, Righi D, Giannico G, Nuzzaci I. Is there any relationship between cold-induced vasodilatation and vasomotion? Microvasc Res 57: 1-7, 1999.
25. Peng H, Matchkov V, Ivarsen A, Aalkjaer C, Nilsson H. Hypothesis for the initiation of vasomotion. Circ Res 88: 810-815, 2001.
26. Podgoreanu MV, Stout RG, El-Moalem HE, Silverman DG. Synchronous rhythmical vasomotion in the human cutaneous microvasculature during nonpulsatile cardiopulmonary bypass. Anesthesiology 97: 1110-1117, 2002.
27. Silverman DG, Jotkowitz AB, Freemer M, Gutter V, O'Connor TZ, Braverman IM. Peripheral assessment of phenylephrine-induced vasoconstriction by laser Doppler flowmetry and its potential relevance to homeostatic mechanisms. Circulation 90: 23-26, 1994.
28. Silverman DG, Stout RG. Distinction between atropine-sensitive control of microvascular and cardiac oscillatory activity. Microvasc Res 63: 196-208, 2002.
29. Silverman DG, Stout RG, Lee FA, Ferneini EM. Detection and characterization of cholinergic oscillatory control in the forehead microvasculature in response to systemic alpha-agonist infusion in healthy volunteers. Microvasc Res 61: 144-147, 2001.
30. Singel DJ, Stamler JS. Blood traffic control. Nature 430: 297, 2004.
31. Stansberry KB, Peppard HR, Babyak LM, Popp G, McNitt PM, Vinik AI. Primary nociceptive afferents mediate the blood flow dysfunction in nonglabrous (hairy) skin of type 2 diabetes: a new model for the pathogenesis of microvascular dysfunction. Diabetes Care 22: 1549-1554, 1999.
32. Stansberry KB, Shapiro SA, Hill MA, McNitt PM, Meyer MD, Vinik AI. Impaired peripheral vasomotion in diabetes. Diabetes Care 19: 715-721, 1996.
33. Stehouwer CD, Huijberts MS, Houben AJ, Schaper NC. Endothelial dysfunction. In: The Diabetic Kidney, edited by Cortes P, Mogensen CE. Totowa, NJ: Humana, 2006, p. 515-525.
34. Vinik AI, Erbas T, Park TS, Stansberry KB, Scanelli JA, Pittenger GL. Dermal neurovascular dysfunction in type 2 diabetes. Diabetes Care 24: 1468-1475, 2001.
35. Wallace TM, Matthews DR. The assessment of insulin resistance in man. Diabet Med 19: 527-534, 2002.
36. Wilkin JK. Poiseuille, periodicity, and perfusion: rhythmic oscillatory vasomotion in the skin. J Invest Dermatol 93: 113S-118S, 1989.