ODN-based drugs for targeting of extracellular proteins

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 8-9, 2007, Pages 1047-1050

  Bucci, E M ^a,b   Valente, M ^a   Musumeci, D ^c   Sapio, R ^a   Anro V ^a   Roviello, G N ^c   Moccia, M ^c  

^a Bionucleon Srl   (Italy)

^b Bioindustry Park del Canavese   (Italy)

^c CNR   (Italy)

Author keywords

Extracellular proteins; Oligonucleotide based drugs; Target validation

Indexed keywords

NUCLEIC ACID BINDING PROTEIN; OLIGONUCLEOTIDE;

ARTICLE; CELL MIGRATION; DATA BASE; DNA BINDING; INFLAMMATION; PROTEIN TARGETING; RNA BINDING; SCREENING;

BINDING SITES; BLOOD PROTEINS; DRUG DESIGN; GENE TARGETING; HMGB1 PROTEIN; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; OLIGODEOXYRIBONUCLEOTIDES;

EID: 36849050680     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701509602     Document Type: Article

References (5)

1. (a) Uhlmann, E.; Peyman, A. Antisense oligonucleotides: A new therapeutic principle. Chem. Rev. 1990, 90, 543-584;
2. b) Oligonucleotides: Antisense Inhibitors of Gene Expression, Cohen, J.S. Ed., CRC Press, Boca Raton, FL, 1989.
3. Mann, M.J.; Dzau, V.J. Therapeutic applications of transcription factor decoy oligonucleotides. J. Clin. Invest. 2000, 106, 1071-1075.
4. Yang, H.; Wang, H.; Tracey K.J. HMG-1 rediscovered as a cytokine. Shock 2001, 15, 247-253.
5. Barone, D.G.; Bianchi, M.E.; Bucci, E.M.; Fumero, S.; Valente, M.; Sapio, R.; Musumeci, D. Therapeutic agents comprising synthetic double-stranded nucleic acid with a bent shape structure for the treatment of HMGB1-related pathologies. PCT Int. Appl. 2006, WO2006002971.