Six-Month Prospective Life Charting of Mood Symptoms with Lamotrigine Monotherapy Versus Placebo in Rapid Cycling Bipolar Disorder

Biological Psychiatry

Volumn 63, Issue 1, 2008, Pages 125-130

  Goldberg, Joseph F ^a,b   Bowden, Charles L ^c   Calabrese, Joseph R ^d   Ketter, Terence A ^e   Dann, Rebekkah S ^f   Frye, Mark A ^g   Suppes, Trisha ^h   Post, Robert M ⁱ  

^a SILVER HILL HOSPITAL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f GLAXOSMITHKLINE   (United States)

^g MAYO CLINIC   (United States)

^h UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

ⁱ PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Bipolar disorder; lamotrigine; Life Chart Method; mood stabilizer; rapid cycling

Indexed keywords

LAMOTRIGINE; PLACEBO;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MOOD CHANGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RATING SCALE; SELF REPORT; TREATMENT DURATION;

ADULT; ANALYSIS OF VARIANCE; ANTICONVULSANTS; BIPOLAR DISORDER; CHI-SQUARE DISTRIBUTION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEASONAL AFFECTIVE DISORDER; SEVERITY OF ILLNESS INDEX; TRIAZINES;

EID: 36849045846     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.12.031     Document Type: Article

References (43)

1. Gottschalk A., Bauer M.S., and Whybrow P.C. Evidence of chaotic mood variation in bipolar disorder. Arch Gen Psychiatry 52 (1995) 947-959
2. Frankenburg F.R., and Zanarini M.C. Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: A double-blind placebo-controlled pilot study. J Clin Psychiatry 63 (2002) 442-446
3. Tritt K., Nickel C., Lahmann C., Leiberich P.K., Rother W.K., Loew T.H., et al. Lamotrigine treatment of aggression in female-borderline patients: A randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 19 (2005) 287-291
4. Preston G.A., Marchant B.K., Reimherr F.W., Strong R.E., and Hedges D.W. Borderline personality disorder in patients with bipolar disorder and response to lamotrigine. J Affect Disord 79 (2004) 297-303
5. Sachs G.S., Printz D.J., Kahn D.A., Carpenter D., and Docherty J.P. The Expert Consensus Guideline Series: Medication Treatment of Bipolar Disorder 2000. Postgrad Med (2000) Spec No:1-104
6. Ghaemi S.N. On defining "mood stabilizer.". Bipolar Disord 3 (2001) 154-158
7. Keck Jr. P.E., McElroy S.L., Richtand N., and Tohen M. What makes a drug a primary mood stabilizer?. Mol Psychiatry 7 suppl 1 (2002) S8-S14
8. Bauer M.S., and Mitchner L. What is a mood stabilizer?. An evidence-based response. Am J Psychiatry 161 (2004) 3-18
9. Keller M.B., Lavori P.W., Kane J.M., Gelenberg A.J., Rosenbaum J.F., Walzer E.A., et al. Subsyndromal symptoms in bipolar disorder. A comparison of standard and low serum levels of lithium. Arch Gen Psychiatry 49 (1992) 371-376
10. Altshuler L.L., Gitlin M.J., Mintz J., Leight K.L., and Frye M.A. Subsyndromal depression is associated with functional impairment in patients with bipolar disorder. J Clin Psychiatry 63 (2002) 807-811
11. Perlis R.H., Ostacher M.J., Patel J.K., Marangell L.B., Zhang H., Wisniewski S.R., et al. Predictors of recurrence in bipolar disorder: Primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 163 (2006) 217-224
12. Tohen M., Bowden C.L., Calabrese J.R., Lin D., Forrester T.D., Sachs G.S., et al. Influence of sub-syndromal symptoms after remission from manic or mixed episodes. Br J Psychiatry 189 (2006) 515-519
13. Frye M.A., Yatham L.N., Calabrese J.R., Bowden C.L., Ketter T.A., Suppes T., et al. Incidence and time course of sub-syndromal symptoms in patients with bipolar I disorder: An evaluation of two placebo-controlled maintenance trials. J Clin Psychiatry 67 11 (2006) 1721-1728
14. Goodwin G.M., Bowden C.L., Calabrese J.R., Grunze H., Kasper K., White R., et al. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry 65 (2004) 432-441
15. Calabrese J.R., Bowden C.L., Sachs G.S., Ascher J.A., Monaghan E., and Rudd G.D. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 60 (1999) 79-88
16. Frye M.A., Ketter T.A., Kimbrell T.A., Dunn R.T., Speer A.M., Osuch E.A., et al. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol 20 (2000) 607-614
17. Post R.M., Roy-Byrne P.P., and Uhde T.W. Graphic representation of the life course of illness in patients with affective disorder. Am J Psychiatry 145 (1988) 844-848
18. Roy-Byrne P., Post R.M., Uhde T.W., Porcu T., and Davis D. The longitudinal course of recurrent affective illness: Life chart data from research patients at the NIMH. Acta Psychiatr Scand Suppl 317 (1985) 1-34
19. Calabrese J.R., Suppes T., Bowden C.L., Sachs G.S., Swann A.C., McElroy S.L., et al. A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry 61 (2000) 841-850
20. Calabrese J.R., Shelton M.D., Rapport D.J., Youngstrom E.A., Jackson K., Bilali S., et al. A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder. Am J Psychiatry 162 (2005) 2152-2161
21. Calabrese J.R., Shelton M.D., Bowden C.L., Rapport D.J., Suppes T., Shirley E.R., et al. Bipolar rapid cycling: Focus on depression as its hallmark. J Clin Psychiatry 62 suppl 14 (2001) 34-41
22. Coryell W., Solomon D., Turvey C., Keller M., Leon A.C., Endicott J., et al. The long-term course of rapid-cycling bipolar disorder. Arch Gen Psychiatry 60 (2003) 914-920
23. First M.B., Spitzer R.L., Gibbon M., and Williams J. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-I/P, version 2.0) (1995), New York State Psychiatric Institute, Biometrics Research Department, New York
24. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 23 (1960) 56-62
25. Endicott J., and Spitzer R.I. A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 35 (1978) 837-844
26. Denicoff K.D., Smith-Jackson E.E., Disney E.R., Suddath R.L., Leverich G.S., and Post R.M. Preliminary evidence of the reliability and validity of the prospective life-charting methodology (LCM-p). J Psychiatr Res 31 (1997) 593-603
27. Denicoff K.D., Leverich G.S., Nolen W.A., Rush A.J., McElroy S.L., Keck P.E., et al. Validation of the prospective NIMH-Life-Chart (NIMH-LCM-p) for longitudinal assessment of bipolar illness. Psychol Med 30 (2000) 1391-1397
28. Denicoff K.D., Ali S.O., Sollinger A.B., Smith-Jackson E.E., Leverich G.S., and Post R.M. Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorder. Depress Anxiety 15 (2002) 1-9
29. Leverich G.S., Altshuler L.L., Frye M.A., Suppes T., McElroy S.L., Keck Jr. P.E., et al. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am J Psychiatry 163 (2006) 232-239
30. Post R.M., Denicoff K.D., Leverich G.S., Altshuler L.L., Frye M.A., Suppes T.M., et al. Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH Life Chart Method. J Clin Psychiatry 64 (2003) 680-690
31. Koukopoulos A., Sani G., Koukopoulos A.E., Minnai G.P., Girardi P., Pani L., et al. Duration and stability of the rapid cycling course: A long-term personal follow-up of 109 patients. J Affect Disord 73 (2003) 75-85
32. Hu F.B., Goldberg J., Hedeker D., Flay B.R., and Pentz M.A. Comparison of population-averaged and subject-specific approaches for analyzing repeated binary outcomes. Am J Epidemiol 147 (1998) 694-703
33. Zajecka J.M., Weisler R., Sachs G., Swann A.C., Wozniak P., and Sommerville K.W. A comparison of the efficacy, safety, and tolerability of divalproex sodium and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry 63 (2002) 1148-1155
34. Bowden C.L., Calabrese J.R., McElroy S.L., Gyulai L., Wassef A., Petty F., et al. A randomized, placebo-controlled, 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Arch Gen Psychiatry 57 (2000) 481-489
35. Tohen M., Chengappa K.N.R., Suppes T., Baker R.W., Zarate C.A., Bowden C.L., et al. Relapse prevention in bipolar I disorder: 18 month comparison of olanzapine plus mood stabilizer v. mood stabilizer alone. Br J Psychiatry 184 (2004) 337-345
36. Post R.M., and Luckenbaugh D.A. Unique design issues in clinical trials of patients with bipolar affective disorder. J Psychiatr Res 37 (2003) 61-73
37. Woyshville M.J., Lackamp J.M., Eisengart J.A., and Gilliland A.J. On the meaning and measurement of affective instability: Clues from chaos theory. Biol Psychiatry 45 (1999) 261-269
38. Mackinnon D.F., and Pies R. Affective instability as rapid cycling: Theoretical and clinical implications for borderline personality and bipolar spectrum disorders. Bipolar Disord 8 (2006) 1-14
39. Tolpin L.H., Gunthert K.C., Cohen L.H., and O'Neill S.C. Borderline personality features and instability of daily negative affect and self-esteem. J Person 72 (2004) 111-137
40. Koenigsberg H.W., Harvey P.D., Mitropoulou V., Schmeidler J., New A.S., Goodman M., et al. Characterizing affective instability in borderline personality disorder. Am J Psychiatry 159 (2002) 784-788
41. Henry C., Mitropoulou V., New A.S., Koenigsberg H.W., Silverman J., and Siever L.J. Affective instability and impulsivity in borderline personality and bipolar II disorders: Similarities and differences. J Psychiatr Res 35 (2001) 307-312
42. Deltito J., Martin L., Riefkohl J., Austria B., Kissilenko A., Corless C., et al. Do patients with borderline personality disorder belong to the bipolar spectrum?. J Affect Disord 67 (2001) 221-228
43. Garno J.L., Goldberg J.F., Ramirez P.M., and Ritzler B.A. Bipolar disorder with comorbid cluster B personality disorder features: Impact on suicidality. J Clin Psychiatry 66 (2005) 339-3345