Gene expression profiling for understanding chemical causation of biological effects for complex mixtures: A case study on estrogens

Environmental Science and Technology

Volumn 41, Issue 23, 2007, Pages 8187-8194

  Filby, Amy L ^a   Santos, Eduarda M ^a   Thorpe, Karen L ^a,b   Maack, Gerd ^a   Tyler, Charles R ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOLOGICAL ORGANS; CONCENTRATION (PROCESS); HORMONES;

ESTROGEN EXPOSURE; FEMINIZATION;

GENE EXPRESSION;

ESTRADIOL; ESTROGEN; ETHINYLESTRADIOL;

ALCOHOLS; BIOLOGICAL ORGANS; CONCENTRATION (PROCESS); GENE EXPRESSION; HORMONES;

CYPRINID; DOSE-RESPONSE RELATIONSHIP; FEMINIZATION; GENE EXPRESSION; PHENOTYPE; POLLUTION EXPOSURE; POLYMERASE CHAIN REACTION; SEX HORMONE; STEROID; WASTEWATER; WATER TREATMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGY; CONTROLLED STUDY; EXPOSURE; FEMALE; FEMINIZATION; FISH; GENE ACTIVITY; GENE EXPRESSION; GONAD; GROWTH, DEVELOPMENT AND AGING; LIVER; MALE; NONHUMAN; PHENOTYPE; PIMEPHALES PROMELAS; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; STATISTICAL MODEL; WASTE WATER MANAGEMENT;

ANIMALS; CYPRINIDAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; GONADS; LIVER; MALE; VITELLOGENINS;

PIMEPHALES PROMELAS;

EID: 36849031280     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es071278v     Document Type: Article

References (38)

1. Tyler, C. R.; Jobling, S.; Sumpter, J. P. Endocrine disruption in wildlife: a critical review of the evidence. Crit. Rev. Toxicol. 1998, 28, 319-361.
2. Purdom, C. E.; Hardiman, P. A.; Bye, V. J.; Eno, N. C.; Tyler, C. R.; Sumpter, J. P. Oestrogenic effects of effluents from sewage treatment works. Chem. Ecol. 1994, 8, 275-285.
3. Jobling, S.; Nolan, M.; Tyler, C. R.; Brighty, G.; Sumpter, J. P. Widespread sexual disruption in wild fish. Environ. Sci. Technol. 1998, 32, 2498-2506.
4. Folmar, L. C.; Denslow, N. D.; Rao, V.; Chow, M.; Crain, D. A.; Enblom., J.; Marcino, J.; Guillette, L. Vitellogenin induction and reduced serum testosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant. Environ. Health Perspect. 1996, 104, 1096-1101.
5. Jobling, S.; Beresford, N.; Nolan, M.; Rodgers-Gray, T.; Brighty, G. C.; Sumpter, J. P.; Tyler, C. R. Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol. Reprod. 2002, 66, 272-281.
6. Jobling, S.; Coey, S.; Whitmore, J. G.; Kime, D. E.; Van Look, K.J.W.; McAllister, B. G.; Beresford, N.; Henshaw, A. C.; Brighty, G.; Tyler, C. R.; Sumpter, J. P. Wild intersex roach (Rutilus rutilus) have reduced fertility. Biol. Reprod. 2002, 67, 515-524.
7. Desbrow, C.; Routledge, E. J.; Brighty, G. C.; Sumpter, J. P.; Waldock, M. Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening. Environ. Sci. Technol. 1998, 32, 1549-1558.
8. Filby A. L., Neuparth T., Thorpe K. L., Owen R., Galloway T. S., Tyler C. R. Health effects of estrogens in the environment, considering complex mixture effects. Environ. Health Perspect. 2007,in press.
9. Watanabe, H.; Suzuki, A.; Kobayashi, M.; Lubahn, D. B.; Handa, H.; Iguchi, T. Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens. J. Mol. Endocrinol. 2003, 31, 487-497.
10. Moggs, J. G.; Ashby, J.; Tinwell, H.; Lim, F. L.; Moore, D. J.; Kimber, I.; Orphanides, G. The need to decide if all estrogens are intrinsically similar. Environ. Health Perspect. 2004, 112, 1137-1142.
11. Larkin, P.; Sabo-Attwood, T.; Denslow, N. D. Gene expression analysis of largemouth bass exposed to estradiol, nonylphenol, and p,p′DDE. Comp. Biochem. Physiol., Part B: Biochem. Mol. Biol. 2002, 133, 543-557.
12. Moens, L. N.; van der Ven, K.; Van Remortel, P.; Del-Favero, J.; De Coen, W. M. Expression profiling of endocrine disrupting compounds using a customized Cyprinus carpio cDNA microarray. Toxicol. Sci. 2006, 93, 298-310.
13. Finne, E. F.; Cooper, G. A.; Koop, B. F.; Hylland, K.; Tollefsen, K. E. Toxicogenomic responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to model chemicals and a synthetic mixture. Aquat. Toxicol. 2007, 81, 293-303.
14. Krasnov, A.; Afanasyev, S.; Oikari, A. Hepatic responses of gene expression in juvenile brown trout (Salmo trutta lacustris) exposed to three model contaminants applied singly or in combination. Environ. Toxicol. Chem. 2007, 26, 100-109.
15. Thorpe K. L.; Benstead R.; Eccles P.; Maack G.; Williams T.; Tyler C. R. Effective assessment of the estrogenic activity of effluents using a laboratory flow-through exposure system. Environ. Sci. Technol. 2007, submitted.
16. Filby, A. L.; Tyler, C. R. Molecular characterization of estrogen receptors 1, 2a, and 2b and their tissue and ontogenic expression profiles in fathead minnow (Pimephales promelas). Biol. Reprod. 2005, 73, 648-662.
17. -ΔΔCT method. Methods 2001, 25, 402-408.
18. Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29, e45.
19. Filby, A. L.; Thorpe, K. L.; Tyler, C. R. Multiple molecular effect pathways for an environmental oestrogen in fish. J. Mol. Endocrinol. 2006, 37, 121-134.
20. Filby, A. L.; Thorpe, K. L.; Maack, G.; Tyler, C. R. Gene expression profiles revealing the mechanisms of anti-androgen- and estrogen-induced feminization in fish. Aquat. Toxicol. 2007, 81, 219-231.
21. Klaper, R.; Rees, C. B.; Drevnick, P.; Weber, D.; Sandheinrich, M.; Carvan, M. J. Gene expression changes related to endocrine function and decline in reproduction in fathead minnow (Pimephales promelas) after dietary methylmercury exposure. Environ. Health Perspect. 2006, 114, 1337-1343.
22. Pinto, P. I.; Singh, P. B.; Condeca, J. B.; Teodosio, H. R.; Power, D. M.; Canario, A. V. ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis. Reprod. Biol. Endocrinol. 2006, 4, 67.
23. Seo, J. S.; Lee, Y. M.; Jung, S. O.; Kim, I. C.; Yoon, Y. D.; Lee, J. S. Nonylphenol modulates expression of androgen receptor and estrogen receptor genes differently in gender types of the hermaphroditic fish Rivulus marmoratus. Biochem. Biophys. Res. Commun. 2006, 346, 213-223.
24. Van den Belt, K.; Berckmans, P.; Vangenechten, C.; Verheyen, R.; Witters, H. Comparative study on the in vitro/in vivo estrogenic potencies of 17β-estradiol, estrone, 17α-ethynylestradiol and nonylphenol. Aquat. Toxicol. 2004, 66, 183-195.
25. Wang, D. Y.; McKague, B.; Liss, S. N.; Edwards, E. A. Gene expression profiles for detecting and distinguishing potential endocrine-disrupting compounds in environmental samples. Environ. Sci. Technol. 2004, 38, 6396-6406.
26. MacKay, M. E.; Raelson, J.; Lazier, C. B. Up-regulation of estrogen receptor mRNA and estrogen receptor activity by estradiol in liver of rainbow trout and other teleostean fish. Comp. Biochem. Physiol. C. 1996, 115, 201-209.
27. Callard, G. V.; Tchoudakova, A. V.; Kishida, M.; Wood, E. Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. J. Steroid Biochem. Mol. Biol. 2001, 79, 305-314.
28. Govoroun, M.; McMeel, O. M.; Mecherouki, H.; Smith, T. J.; Guiguen, Y. 17β-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis. Endocrinology 2001, 142, 1841-1848.
29. Harvey, S.; Baudet, M. L.; Murphy, A.; Luna, M.; Hull, K. L. Aramburo C. Testicular growth hormone (GH): GH expression in spermatogonia and primary spermatocytes. Gen. Comp. Endocrinol. 2004, 139, 158-167.
30. Blanton, M. L.; Specker, J. L. The hypothalamic-pituitary-thyroid (HPT) axis in fish and its role in fish development and reproduction. Crit. Rev. Toxicol. 2007, 37, 97-115.
31. Aherne, G. W.; Briggs, R. The relevance of the presence of certain synthetic steroids in the aquatic environment. J. Pharm. Pharmacol. 1989, 41, 735-736.
32. Ternes, T. A.; Stumpf, M.; Mueller, J.; Habener, K.; Wilken, R. D.; Servos, M. Behaviour and occurrence of estrogens in municipal sewage treatment plants. I. Investigations in Germany, Canada and Brazil. Sci. Total Environ. 1999, 225, 81-90.
33. Navas, J.; Segner, H. Estrogen-mediated suppression of cytochrome P4501A (CYP1A) expression in rainbow trout hepatocytes: role of estrogen receptor. Chem.-Biol. Interact. 2001, 138, 285-298.
34. Bucheli, T. D.; Fent, K. Induction of cytochrome P450 in fish as a biomarker for environmental contamination in aquatic ecosystems. Crit. Rev. Environ. Sci. Technol. 1995, 25, 200-268.
35. Kuiper, G. G. J. M.; Carlsson, B.; Grandien, K.; Enmark, E.; Haggblad, J.; Nilsson, S.; Gustafsson, J. A. Comparison of ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997, 138, 863-870.
36. von Hofsten, J.; Olsson, P. E. Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes. Reprod. Biol Endocrinol. 2005, 3, 63.
37. Josso, N.; Racine, C.; di Clernente, N.; Rey, R.; Xavier, F. The role of anti Mullerian hormone in gonadal development. Mol Cell. Endocrinol. 1998, 145, 3-7.
38. Kobayashi, T.; Matsuda, M.; Kajiura-Kobayashi, H.; Suzuki, A.; Saito, N.; Nakamoto, M.; Shibata, N.; Nagahama, Y. Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes. Dev. Dyn. 2004, 231, 518-526.