Frequency and clinical significance of human β-herpesviruses in cervical samples from Italian women

Journal of Medical Virology

Volumn 80, Issue 1, 2008, Pages 147-153

  Broccolo, Francesco ^a,d   Cassina, G ^a   Chiari, S ^b   Garcia Parra, R ^a,b   Villa, A ^b   Leone, B E ^b   Brenna, A ^b   Locatelli, G ^c   Mangioni, C ^b   Cocuzza, C E ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c Pharmacia   (Italy)

^d Department of Clinical Medicine and Prevention ^*  (Italy)

Author keywords

CMV; HHV 6; HHV 7; HPV; Precancerous lesions; Quantitative real time PCR

Indexed keywords

ARTICLE; CANCER GROWTH; CANCER RISK; CARCINOGENESIS; CLINICAL FEATURE; CYTOLOGY; CYTOMEGALOVIRUS; DISEASE ASSOCIATION; FEMALE; FREQUENCY ANALYSIS; HUMAN; HUMAN PAPILLOMAVIRUS 31; HUMAN PAPILLOMAVIRUS 7; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; ITALY; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER; VIRUS LOAD; WART VIRUS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; CERCOPITHECUS AETHIOPS; CERVIX UTERI; CROSS-SECTIONAL STUDIES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 7, HUMAN; HUMANS; POLYMERASE CHAIN REACTION; UTERINE CERVICAL NEOPLASMS; VERO CELLS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRIDAE;

EID: 36849007825     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21054     Document Type: Article

References (33)

1. Bosch FX, Lorincz A, Munoz N, Meijer CJLM, Shah KV. 2002. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55:244-265.
2. Broccolo F, Drago F, Careddu AM, Foglieni C, Turbino L, Cocuzza CE, Gelmetti C, Lusso P, Rebora AE, Malnati MS. 2005. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. J Invest Dermatol 124:1234-1240.
3. Calleja-Macias IE, Villa LL, Prado JC, Kalantari M, Allan B, Williamson AL, Chung LP, Collins RJ, Zuna RE, Dunn ST, Chu TY, Cubie HA, Cuschieri K, von Knebel-Doeberitz M, Martins CR, Sanchez GI, Bosch FX, Munoz N, Bernard HU. 2005. Worldwide genomic diversity of the high-risk human papillomavirus types 31, 35, 52,and 58, four close relatives of human papillomavirus type 16. J Virol 79:13630-13640.
4. Chan PKS, Chan MYM, Li WWH, Chan DPC, Cheung JLK, Cheng AF. 2001. Association of human beta-HHVs with the development of cervical cancer: Bystanders or cofactors. J Clin Pathol 54:48-53.
5. Chen M, Wang H, Woodworth CD, Lusso P, Bernemen Z, Kingma D, Delgado G, DiPaolo JA. 1994a. Detection of human herpesvirus 6 and human papillomavirus 16 in cervical carcinoma. Am J Pathol 145:1509-1516.
6. Chen M, Popescu N, Woodworth C, Beneman Z, Corbellino M, Lusso P, Ablashi DV, DiPaolo JA. 1994b. Human herpesvirus 6 infects cervical epithelial cells and transactivates human papillomavirus gene expression. J Virol 68:1173-1178.
7. De Francesco MA, Gargiulo F, Schreiber C, Ciravolo G, Salinaio F, Manca N. 2005. Detection and genotyping of human papillomavirus in cervical samples from Italian patients. J Med Virol 75:588-592.
8. de Roda Husman AM, Walboomers JMM, Van Den Brule AJC, Meijer CJLM, Snijders PJF. 1995. The use of general primers GP5 and GP6 elongated at their 39 ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76:1057-1062.
9. Del Mistro A, Bonaldi L, Bertorelle R, Minucci D, Franzetti M, Cattelan A, Bonoldi E, Sposetti R, Torrisi A, Chieco-Bianchi L. 2001. Genital human papillomavirus types in immunocompetent and immunodepressed women in Northeast Italy: Prevalence and cytomorphological correlations. J Low Genit Tract Dis 5:12-20.
10. DiPaolo JA, Popescu NC, Woodworth CD, Zimonjic DB. 1996. Papillomaviruses and potential copathogens. Toxicol Lett 88:1-7.
11. Gargiulo F, De Francesco MA, Schreiber C, Ciravolo G, Salinaro F, Valloncini B, Manca N. 2007. Prevalence and distribution of single and multiple HPV infections in cytologically abnormal cervical samples from Italian women. Virus Res 125:176-182.
12. Goldstein SC, Byrne JC, Rabson AS. 1987. Human cytomegalovirus (HCMV) enhances bovine papilloma virus (BPV) transformation in vitro. J Med Virol 23:157-164.
13. Gradilone A, Vercillo R, Napolitano M, Cardinali G, Gazzaniga P, Silvestri I, Gandini O, Tomao S, Agliano AM. 1996. Prevalence of human papillomavirus, cytomegalovirus, and Epstein-Barr virus in the cervix of healthy women. J Med Virol 50:1-4.
14. Han CP, Tsao YP, Sun CA, Ng HT, Chen SL. 1997. Human papillomavirus, cytomegalovirus and herpes simplex virus infections for cervical cancer in Taiwan. Cancer Lett 120:217-221.
15. Herrington CS. 1995. Human papillomaviruses and cervical neoplasia. II. Interaction of HPV with other factors. J Clin Pathol 48:1-6.
16. Jacobs MV, de Roda Husman AM, van den Brule AJ, Snijders PJ, Meijer CJ, Walboomers JM. 1995. Group-specific differentiation between high- and low-risk human papillomavirus genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes. J Clin Microbiol 33:901-905.
17. Lanham S, Herbert A, Basarab A, Watt P. 2001. Detection of cervical infections in colposcopy clinic patients. J Clin Microbiol 39:2946-2950.
18. Leach CT, Newton ER, McParlin S, Jenson HB. 1993. Human herpesvirus 6 infection of the female genital tract. J Infect Dis 169:1281-1283.
19. Leong HN, Tuke PW, Tedder RS, Khanom AB, Eglin RP, Atkinson CE, Ward KN, Griffiths PD, Clark DA. 2007. The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. J Med Virol 9:45-51.
20. Locatelli G, Santoro F, Veglia F, Gobbi A, Lusso P, Malnati MS. 2000. Real-time quantitative PCR for human herpesvirus 6 DNA. J Clin Microbiol 38:4042-4048.
21. McDougall JK. 1994. Cofactors in the progression of HPV-associated tumors. Antibiot Chemother 46:150-164.
22. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, Snijders PJ, Meijer CJ. 2003. International Agency for Research on Cancer Multicenter Cervical Cancer Study Group. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518-527.
23. Okuno T, Oishi H, Hayashi K, Nonogaki M, Tanaka K, Yamanishi K. 1995. Human HHVs 6 and 7 in cervixes of pregnant women. J Clin Microbiol 33:1968-1970.
24. Qu W, Jiang G, Cruz Y, Chang CJ, Ho GY, Klein RS, Burk RD. 1997. PCR detection of human papillomavirus: Comparison between MY09/MY11 and GP5+/GP6+ primer systems. J Clin Microbiol 35:1304-1310.
25. Rassu M, Bertoloni G, Mengoli C, Peron A, Benedetti P, Palu G. 2005. HPV genotype prevalence in cervical specimens with abnormal cytology: A report from north-east Italy. Scand J Infect Dis 37:476-481.
26. Romano N, Romano FM, Viviano E, Vitale F, Villafrate MR, Perna AM, Bonura F, Guttadauro R. 1996. Rare association of human herpesvirus 6 DNA with human papillomavirus DNA in cervical smears of women with normal and abnormal cytologies. J Clin Microbiol 34:1589-1591.
27. Thompson CH, Rose BR, Elliott PM. 1997. Cytomegalovirus and cervical cancer: Failure to detect a direct association or an interaction with human papillomaviruses. Gynecol Oncol 54:40-46.
28. Tornesello ML, Duraturo ML, Botti G, Greggi S, Piccoli R, De Palo G, Montella M, Buonaguro L, Buonaguro FM. 2006. Italian HPV Working Group. Prevalence of alpha-papillomavirus genotypes in cervical squamous intraepithelial lesions and invasive cervical carcinoma in the Italian population. J Med Virol 78:1663-1672.
29. Tran-Thanh D, Koushik A, Provencher D, Drouin P, Dubuc-Lissoir J, Gauthier P, Allaire G, Kornegay J, Franco E, Coutlee F. 2002. Detection of human herpes virus type 6 DNA in precancerous lesions of the uterine cervix. J Med Virol 68:606-610.
30. Wang H, Chen M, Berneman ZN, Delgado G, DiPaolo JA. 1994. Detection of human herpesvirus-6 in paraffin-embedded tissue of cervical cancer by polymerase chain reaction. J Virol Methods 47: 297-305.
31. Ward KN, Leong HN, Nacheva EP, Howard J, Atkinson CE, Davies NW, Griffiths PD, Clark DA. 2006. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J Clin Microbiol 44:1571-1574.
32. Yadav M, Arivananthan M, Kumar S. 1996. HHV-6 antigen and viral DNA detected in cervical cells from archived tissue using histochemical staining and hybridization. Clin Diagn Virol 7:23-23.
33. Zerbini M, Venturoli S, Cricca M, Gallinella G, De Simone P, Costa S, Santini D, Musiani M. 2001. Distribution and viral load of type specific HPVs in different cervical lesions as detected by PCR-ELISA. J Clin Pathol 54:377-380.