Does intraosseous equal intravenous? A pharmacokinetic study

American Journal of Emergency Medicine

Volumn 26, Issue 1, 2008, Pages 31-38

  Von Hoff, Daniel D ^a   Kuhn, John G ^b   Burris III, Howard A ^c   Miller, Larry J ^d  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c CENTENNIAL MEDICAL CENTER   (United States)

^d Vidacare Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE SULFATE;

ADULT; AGED; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BONE MARROW; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; FEMALE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICAL INSTRUMENTATION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; TIME TO MAXIMUM PLASMA CONCENTRATION; VENOUS BLOOD;

ADULT; ANALGESICS, OPIOID; AREA UNDER CURVE; CATHETERS, INDWELLING; CROSS-OVER STUDIES; EMERGENCY MEDICAL SERVICES; HUMANS; INFUSIONS, INTRAOSSEOUS; MORPHINE; NEOPLASMS; PROSPECTIVE STUDIES; THERAPEUTIC EQUIVALENCY;

EID: 36849003969     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2007.03.024     Document Type: Article

References (19)

1. Dubick M.A., and Holcomb J.B. A review of intraosseous access: current status and military application. Mil Med 165 (2000) 552-558
2. In: Hazinski M.F. (Ed). Pediatric life support (PALS) provider manual (2002), American Heart Association, Dallas (Tex)
3. ACLS Guidelines. Part 7.2 management of cardiac arrest. Circulation 112 (2005) 170-171
4. Orlowski J.P., Porembka D.T., Gallagher J.M., Lockrem J.D., and VanLente F. Comparison study of intraosseous, central intravenous, and peripheral intravenous infusions of emergency drugs. Am J Dis Child 144 (1990) 112-117
5. Orlowski J.P. Emergency alternatives to intravenous access: intraosseous, intratracheal, and other-site drug administration. Pediatr Clin North Am 41 (1994) 1183-1199
6. LaRocco B.G., and Wang H.E. Intraosseous infusion. Prehosp Emerg Care 7 (2003) 280-285
7. Brunette D.D., and Fischer R. Intravascular access in pediatric cardiac arrest. Am J Emerg Med 6 (1988) 577-579
8. Rosetti V.A., Thompson B.M., Miller J., Mateer J.R., and Aprahamian C. Intraosseous infusion: an alternative route of pediatric intravascular access. Ann Emerg Med 14 (1985) 885-888
9. Lavis M. Pre-hospital adult intraosseous infusion. Pre-hosp Immed Care 3 (1999) 89-92
10. Jaimovich D.G., Snabino C.L., Ringer T.V., and Peters G.R. Comparison of intraosseous and intravenous routes of anticonvulsant administration in a porcine model. Ann Acad Emerg Med 18 (1989) 842-846
11. Jaimovich D.G., Kumar A., and Francom S. Evaluation of intraosseous vs. intravenous antibiotic levels in a porcine model. AJDC 145 (1991) 946-949
12. Brickman K.R., Rega P., and Guiness M. A comparative study of intraosseous versus peripheral intravenous infusion of diazepam and phenobarbital in dogs. Ann Acad Emerg Med 16 (1987) 1441-1444
13. Cameron J.L., Fontanarosa P.B., and Passalaqua A.M. A comparative study of peripheral to central circulation delivery times between intraosseous and intravenous injection using a radionucleotide technique in normovolemic and hypovolemic canines. J Emerg Med 7 (1989) 123-127
14. Goldstein R., Lavy E., Shem-Tov M., Glickman A., Bark H., and Ziv G. Pharmacokinetics of ampicillin administered intravenously and intraosseously to kittens. Res Vet Sci 59 (1995) 186-187
15. Chastagner P., Lozniewski A., Lascombes P., Barberi-Heyob M., Methers P.M., and Merlin J.L. Pharmacokinetic longitudinal studies of antibiotics administered via a permanent intraosseous device in micropigs. Med Pediatr Oncol 36 (2001) 635-640
16. Golenz M.R., Wilson W.D., Carlson G.P., Craychee T.J., Mihalyi J.E., and Knox L. Effect of route of administration and age on the pharmacokinetics of amikacin administered by the intravenous and intraosseous routes to 3 and 5-day-old foals. Equine Vet J 26 (1994) 367-373
17. Hoskins S., Nascimento P., Espana J., and Kramer G. Pharmacokinetics of intraosseous drug delivery during CPR. Shock 23 (2005) 35
18. Sapien R., Stein H., Padbury J.F., Thio S., and Hodge D. Intraosseous versus intravenous epinephrine infusions in lambs: pharmacokinetics and pharmacodynamics. Pediatr Emerg Care 8 (1992) 179-183
19. Wood M., Reader A., Nusstein J., Beck M., Padgett D., and Weaver J. Comparison of intraosseous and infiltration injections for venous lidocaine blood concentrations and heart rate changes after injection of 2% lidocaine with 1:100,000 epinephrine. J Endod 43 (2005) 5-8