Monitoring cytotoxic potentials of furfuryl alcohol and 2-furyl methyl ketone in mice

Food and Chemical Toxicology

Volumn 46, Issue 1, 2008, Pages 286-292

  Sujatha, P S ^a  

^a OSMANIA UNIVERSITY   (India)

Author keywords

2 Furyl methyl ketone; Alanine aminotransferase; Aspartate aminotransferase; Cytotoxicity; Furfuryl alcohol; Sodium dodecyl sulphate polyacrylamide gel electrophoresis

Indexed keywords

2 FURYL METHYL KETONE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FURAN DERIVATIVE; FURFURYL ALCOHOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; KIDNEY INJURY; LIVER CELL; LIVER INJURY; LIVER TOXICITY; NONHUMAN; PROTEIN CONTENT; RAT;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD PROTEIN ELECTROPHORESIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FURANS; HEPATOCYTES; KETONES; LIVER; MICE; PROTEINS; VACUOLES;

ANIMALIA; MUS;

EID: 36849000816     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.08.008     Document Type: Article

References (38)

1. Battacharya S. Stress response to pesticides and heavy metals in fish and other vertebrates. Proc. Indian Natl. Sci. Acad. (PINSA) 67 (2001) 215-246
2. Browning E. Toxicity and Metabolism of Industrial Solvents (1965), Elsevier, Amsterdam pp. 382-384, 412-424
3. Burka L.T., and Boyd M.R. Furans. In: Anders M.W. (Ed). Bioactivation of Foreign Compounds (1985), Academic Press INC., New York 245-257
4. Burka L.T., Washburn K.D., and Irwin R.D. Disposition of 14C furan in the male F344 rat. J. Toxicol. Environ. Health 34 (1991) 245-257
5. Choudhary B.K., Setoyama C., and Shimda K. Molecular cloning and sequence analysis of the human cytosolic aspartate amino transferase gene. Biochem. Int. 22 (1990) 583-591
6. Dikshith T.S.S., Raizada R.B., Kumar S.N., Srivastava M.K., Kaushal K.A., Singh R.P., and Gupta K.P. Effect of repeated application of Endosulfan to rats. Vet. Hum. Toxicol. 30 (1988) 219-224
7. Dikshith T.S.S., Raizada R.B., Srinivasan M.K., Kaushal K.A., Singh R.P., Gupta K.P., and Lakshmi K.S. Dermal toxicity of Hexachloro cyclohexane (HCH) in rabbit. Ind. J. Exp. Biol. 27 (1989) 252-257
8. Fishbein L. Mutagens and carcinogens in the environment. In: Chopra V.L., Joshi B.C., Sharma R.P., and Bansal H.C. (Eds). Genetics: New Frontiers. Genetics and Health vol. 3 (1984), Oxford and IBH Publishing Company, New Delhi 3-42
9. Gajewsky J.E., and Alsdorf W.R. Studies on furan compounds - Toxicity and pharmacological action of furfuryl alcohol. Fed. Proc. 8 19 (1949) 294
10. Hess B. Biochemistry and biology of plasma enzymes. Proc. Eur. Soc. Study Drug Toxicol. (1965) 37
11. Hook J.B., Mc Cormark K.M., and M Kluwe W. Biochemical mechanism of nephrotoxicity. In: Hodgson E., Bend J.R., and Philpot R.M. (Eds). Reviews in Biochemical Toxicology (1979), Elsevier Publishers, New York 53-73
12. Health and Safety Executive Publications - Chemical Hazard Alert Notice, 33-Furfuryl Alcohol, www.hse.govtuk/pubns/chan33.
13. Jacobson K.H., Rinehan W.E., Wright W.H.J., Ross M.A., Papin J.L., Daly R.C., Greene E.A., and Groff W.A. The toxicology of an anilin-furfuryl alcohol hydreazine mixture. Am. Ind. Hyg. Assoc. J . 19 (1958) 91-99
14. Kulkarni A.P., and Hodgson E. Hepatotoxicity. In: Hodgson E., and Guthrie (Eds). Introduction to Biochemical Toxicology (1980), Elsevier, New York 341-356
15. Lammeli U.K. Cleavage and structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
16. Lowry O.H., Rosebrough N.J., Farr A., and Randall R.J. Protein measurement with the Folin-phenol reagent. J. Biol. Chem. 193 (1951) 265-275
17. Maga J.A. Furans in foods. CRC Crit. Rev. Food Sci. Nutr. 11 (1979) 355
18. Mishra A., Dwivedi P.D., Verma A.S., Sinha M., Mishra J., Lal K., Pandya K.P., and Dutta K.K. Pathological and biochemical alterations induced by inhalation of furfural vapour in rat lung. Bull. Environ. Contam. Toxicol. 47 (1991) 668-674
19. Morimoto R.I. Cells in stress: transcriptional activation of heat shock genes. Science 259 (1993) 1409-1410
20. NTP, 1989. National Toxicology Program. NTP Technical Report 382. Toxicology and Carcinogenesis Studies of Furfural in F344 Rats and B6C3F1 Mice. Research Triangle Park, NC, United States.
21. NTP, 1990. Toxicology and carcinogenesis studies of Furfural in Fisher 344/N Rats and B6C3F1 mice (gavage studies). National Toxicology Programme Technical Report. Series No. 382. Research Triangle Park, NC, United States.
22. Priestly B. Toxicological evaluation of certain food additives and naturally occurring toxicants. WHO Food Additives Series 30 (1993) 271-283
23. Rao C.V., and Banerji S.A. Effect of feeding polychlorinated biphenyl (Aroclor 1260) on hepatic enzymes of rats. J. Exp . Biol. 28 (1990) 149-151
24. Ravinder P., Srinivasan K., and Radhakrishnamurthy R. Biochemical toxicity of Hexachloro cyclohexane and its isomer in albino mice. Ind. J. Exp. Biol. 27 (1989) 248-251
25. Ravindranath V., Burka L.T., and Boyd M.R. Reactive metabolites from the bioactivation of toxic methyl furans. Science 224 (1984) 884-886
26. Ravindranath V., Mc Menamin M.G., Dees J.H., and Boyd M.R. 2-Methyl furan toxicity in rats - role of metabolic activation in vivo. Toxicol. Appl. Pharmacol. 85 (1986) 78-91
27. Sarma A.B., Chakrabarthi J., Chakrabarti A., Banerjee T.S., Roy D., Mukherjee D., and Mukherjee K. Evaluation of pan masala for toxi effects on liver and other organs. Food Chem. Toxicol. 30 (1992) 61-163
28. Savolainen H., and Pfaffli P. Neurotoxicity of Furfuryl alcohol vapour in prolonged inhalation exposure. Environ. Res. 31 (1993) 420-427
29. Stich H.F., Rosin M.P., Wu C.H., and Powrie W.D. Clastogenicity of furans found in food. Cancer Lett. 13 (1981) 89-95
30. Sujatha P.S., and Subramanyam S. Genotoxicity of Furfuryl alcohol in mouse meiocyte test system. J. Cytol. Genet. 28 (1993) 3-17
31. Sujatha P.S., Jayanthi A., and Subramanyam S. Evaluation of clastogenic potential of 2-furyl methyl ketone in in vivo mouse test system. Med. Sci. Res. 21 (1993) 675-678
32. Sujatha P.S., and Subramanyam S. Clastogenicity of Furfuryl alcohol in mouse bone marrow system. Med. Sci. Res. 22 (1994) 81-284
33. In: Timbrell J.A. (Ed). Principles of Biochemical Toxicology (1982), Taylor and Francis Ltd., London 26-145
34. Vatal M., and Aiya A.S. Effect of Lithium carbonate on SGOT GPT and LDH of rats. Ind. J. Exp. Biol. 26 (1988) 801-803
35. Wooton I.D.P. Microanalysis in Medical Biochemistry. fourth ed. (1964), J.A. Churchill LTD, London
36. Zimmerman H.J., Dujovne C.A., and Levy R. The correlation of serum levels to two transaminases with tissue lesion in six vertebrate species. Comp. Biochem. Physiol . 25 (1968) 1081
37. Zimmerman H.J., and Seef L.B. Enzymes in hepatic disease. In: Coodley E.L. (Ed). Diagnostic Enzymology (1970), Lea and Febiger, Philadelphia 1-38
38. Zimmerman, H.J., 1978. Hepatotoxicity - The Adverse Effect of Drugs and Other Chemicals on the Liver. Appleton Century Crofts, New York.