Modulation of anxiety in rats evaluated in the elevated T-maze: Evidence of the relationship between substance P and diazepam

Behavioural Brain Research

Volumn 187, Issue 1, 2008, Pages 140-145

  Duzzioni, Marcelo ^a   Calixto, Ana V ^a   Duarte, Filipe S ^a   De Lima, Thereza C M ^a  

^a CCB   (Brazil)

Author keywords

Anxiety; Diazepam; Elevated T maze; Memory; NK1 receptor; Substance P

Indexed keywords

DIAZEPAM; DIENPAX; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR; PHOSPHATE BUFFERED SALINE; SODIUM CHLORIDE; SUBSTANCE P; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ESCAPE BEHAVIOR; LATENT PERIOD; MALE; MAZE TEST; MEMORY; NEUROMODULATION; NONHUMAN; PARAMETER; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; AVOIDANCE LEARNING; DIAZEPAM; DIPEPTIDES; FEAR; INDOLES; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; MEMORY; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 36749091710     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2007.09.007     Document Type: Article

References (51)

1. Aguiar M.S., and Brandao M.L. Effects of microinjections of the neuropeptide substance P in the dorsal periaqueductal gray on the behaviour of rats in the plus-maze test. Physiol Behav 60 (1996) 1183-1186
2. Argyropoulos S.V., Sandford J.J., and Nutt D.J. The psychobiology of anxiolytic drugs. Part 2: pharmacological treatments of anxiety. Pharmacol Ther 88 (2000) 213-227
3. Bailey C.P., Maubach K.A., and Jones R.S.G. Neurokinin-1 receptors in the rat nucleus tractus solitarius: pre- and postsynaptic modulation of glutamate and GABA release. Neuroscience 127 (2004) 467-479
4. Bueno C.H., Zangrossi Jr. H., and Viana M.B. The inactivation of the basolateral nucleus of the rat amygdala has an anxiolytic effect in the elevated T-maze and light/dark transition tests. Braz J Med Biol Res 38 (2005) 1697-1701
5. Carvalho-Netto E.F., and Nunes-de-Souza R.L. Use to the elevated T-maze to study anxiety in mice. Behav Brain Res 148 (2004) 119-132
6. Chapouthier G., and Venault P. GABA-A receptor complex and memory processes. Med Chem Rev 1 (2004) 91-99
7. Costa J.C., and Tomaz C. Posttraining administration of substance P and its N-terminal fragment block the amnesic effects of diazepam. Neurobiol Learn Mem 69 (1998) 65-70
8. De Araujo J.E., Silva R.C., Huston J.P., and Brandao M.L. Anxiogenic effects of substance P and its 7-11 C terminal, but not the 1-7 N terminal, injected into the dorsal periaqueductal gray. Peptides 20 (1999) 1437-1443
9. Duarte F.S., Testolin R., and De Lima T.C. Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats. Behav Brain Res 154 (2004) 501-510
10. Echeverry M.B., Hasenohrl R.U., Huston J.P., and Tomaz C. Comparison of neurokinin SP with diazepam in effects on memory and fear parameters in the elevated T-maze free exploration paradigm. Peptides 22 (2001) 1031-1036
11. Farkas L., and Crowe S.F. The role of the benzodiazepine-GABA system in the memory processes of the day-old chick. Pharmacol Biochem Behav 65 (2000) 223-231
12. 1 receptor antagonist, FK 888. Br J Pharmacol 107 (1992) 785-789
13. Gavioli E.C., Canteras N.S., and De Lima T.C. Anxiogenic-like effects induced by substance P injected into the lateral septal nucleus. Neuroreport 10 (1999) 3399-3403
14. Gavioli E.C., Canteras N.S., and De Lima T.C. The role of lateral septal NK1 receptors in mediating anxiogenic effects induced by intracerebroventricular injection of substance P. Behav Brain Res 134 (2002) 411-415
15. Gerhardt P., Hasenohrl R.U., and Huston J.P. Enhanced learning produced by injection of neurokinin substance P into the region of the nucleus basalis magnocellularis: mediation by the N-terminal sequence. Exp Neurol 118 (1992) 302-308
16. Graeff F.G., Netto C.F., and Zangrossi Jr. H. The elevated T-maze as an experimental model of anxiety. Neurosci Biobehav Rev 23 (1998) 237-246
17. Graeff F.G., Viana M.B., and Tomaz C. The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam. Braz J Med Biol Res 26 (1993) 67-70
18. Hasenohrl R.U., Jentjens O., De Souza Silva M.A., Tomaz C., and Huston J.P. Anxiolytic-like action of neurokinin substance P administered systemically or into the nucleus basalis magnocellularis region. Eur J Pharmacol 354 (1998) 123-133
19. Hasenohrl R.U., Souza-Silva M.A., Nikolaus S., Tomaz C., Brandao M.L., Schwarting R.K., et al. Substance P and its role in neural mechanisms governing learning, anxiety and functional recovery. Neuropeptides 34 5 (2000) 272-280
20. Hokfelt T., Millhorn D., Seroogy K., Tsuruo Y., Ceccatelli S., Lindh B., et al. Coexistence of peptides with classical neurotransmitters. Experientia 43 (1987) 768-780
21. Hokfelt T.G.M., Castel M.N., Morino P., Zhang X., and Dagerlind A. General overview of neuropeptides. In: Bloom F.E., and Kupfer D.J. (Eds). Psychopharmacology: the fourth generation of progress (1995), Raven Press, New York 483-492
22. Huston J.P., and Hasenohrl R.U. The role of neuropeptides in learning: focus on the neurokinin substance P. Behav Brain Res 66 (1995) 117-127
23. Huston J.P., and Staubli U. Post-trial injection of substance P into lateral hypothalamus and amygdala, respectively, facilitates and impairs learning. Behav Neural Biol 27 (1979) 244-248
24. Huston J.P., and Staubli U. Retrograde amnesia produced by post-trial injection of substance P into substantia nigra. Brain Res 159 (1978) 468-472
25. Lenard L., and Kertes E. Influence of passive avoidance learning by substance P in the basolateral amygdala. Acta Biol Hung 53 (2002) 95-104
26. Maubach K.A., Martin K., Smith D.W., Hewson L., Frankshum R.A., Harrison T., et al. Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro. Neuropharmacology 40 (2001) 806-817
27. Menard J., and Treit D. Effects of centrally administered anxiolytic compounds in animal models of anxiety. Neurosci Biobehav Rev 23 (1999) 591-613
28. Menard J., and Treit D. Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests. Physiol Behav 60 (1996) 845-853
29. Merighi A. Co-storage and co-existence of neuropeptides in the mammalian CNS. Prog Neurobiol 66 (2002) 161-190
30. Morris H.V., Dawson G.R., Reynolds D.S., Atack J.R., and Stephens D.N. Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm. Eur J Neurosci 23 (2006) 2495-2504
31. Mussap C.J., Geraghty D.P., and Burcher E. Tachykinin receptors: a radioligand binding perspective. J Neurochem 60 (1993) 1987-2009
32. Ogier R., and Raggenbass M. Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission. Eur J Neurosci 17 (2003) 2639-2647
33. Otsuka M., and Yoshioka K. Neurotransmitter functions of mammalian tachykinins. Physiol Rev 73 (1993) 229-308
34. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 2nd ed. (1986), Academic Press Australia, Sydney
35. Pesold C., and Treit D. The neuroanatomical specificity of the anxiolytic effects of intra-septal infusions of midazolam. Brain Res 710 (1996) 161-168
36. Ribeiro-da-Silva A., and Hokfelt T. Neuroanatomical localisation of substance P in the CNS and sensory neurons. Neuropeptides 34 (2000) 256-271
37. Ribeiro R.L., and De Lima T.C. Participation of GABAA receptors in the modulation of experimental anxiety by tachykinin agonists and antagonists in mice. Prog Neuropsychopharmacol Biol Psychiatry 26 (2002) 861-869
38. Rodger R.J., and Cole J.C. The elevated plus-maze: pharmacology, methodology and ethology. In: Cooper S.J., and Hendrie C.A. (Eds). Ethology and Psychopharmacology (1994), John & Sons 9-44
39. 1 receptor in the brain: pharmacology and putative functions. Eur J Pharmacol 375 (1999) 51-60
40. Savic M.M., Obradovic D.I., Ugresic N.D., Cook J.M., Sarma P.V., and Bokonjic D.R. Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and β-CCt. Psychopharmacology (Berl) 158 (2005) 293-300
41. Savic M.M., Obradovic D.I., Ugresic N.D., Cook J.M., Yin W., and Bokonjic D.R. Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and β-CCt. Pharmacol Biochem Behav 79 (2004) 279-290
42. Schlesinger K., Lipsitz D.U., Peck P.L., Pelleymounter M.A., Stewart J.M., and Chase T.N. Substance P reversal of electroconvulsive shock and cycloheximide-induced retrograde amnesia. Behav Neural Biol 39 (1983) 30-39
43. Stacey A.E., Woodhall G.L., and Jones R.S.G. Activation of neurokinin-1 receptors promotes GABA release at synapses in the rat entorhinal cortex. Neuroscience 115 (2002) 575-586
44. Staubli U., and Huston J.P. Facilitation of learning by post-trial injection of substance P into the medial septal nucleus. Behav Brain Res 1 (1980) 245-255
45. Teixeira R.C., Zangrossi JrH, and Graeff F.G. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol Biochem Behav 65 (2000) 571-576
46. Teixeira R.M., Santos A.R., Ribeiro S.J., Calixto J.B., Rae G.A., and De Lima T.C. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. Eur J Pharmacol 311 (1996) 7-14
47. Thiebot M.H. Some evidence for amnesic-like effects of benzodiazepines in animals. Neurosci Biobehav Rev 9 (1985) 95-100
48. Tomaz C., Dickinson-Anson H., and Mcgaugh J.L. Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task. Proc Natl Acad Sci USA 89 (1992) 3615-3619
49. Venault P., Chapouthier G., de Carvalho L.P., Simiand J., Morre M., Dodd R.H., et al. Benzodiazepine impairs and beta-carboline enhance performance in learning and memory tasks. Nature 321 (1986) 864-866
50. Viana M.B., Tomaz C., and Graeff F.G. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol Biochem Behav 49 (1994) 549-554
51. Zangrossi JrH, Viana M.B., and Graeff F.G. Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino) tetralin in the elevated T-maze. Eur J Pharmacol 369 (1999) 267-270