Rapid tryptophan depletion as a treatment for acute mania: A double-blind, pilot-controlled study

Bipolar Disorders

Volumn 9, Issue 8, 2007, Pages 884-887

  Applebaum, Julia ^a   Bersudsky, Yuly ^a   Klein, Ehud ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Acute mania; Double blind study; Tryptophan depletion

Indexed keywords

AMINO ACID MIXTURE; LORAZEPAM; METOCLOPRAMIDE; PLACEBO; TRYPTOPHAN; TRYPTOPHAN FREE AMINO ACID MIXTURE; UNCLASSIFIED DRUG; VALPROIC ACID;

ACUTE DISEASE; ADULT; AGITATION; AMINO ACID BLOOD LEVEL; ARTICLE; BRIEF PSYCHIATRIC RATING SCALE; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DOUBLE BLIND PROCEDURE; FEMALE; HAMILTON SCALE; HUMAN; MALE; MANIA; NAUSEA AND VOMITING; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SLEEP DISORDER;

ADULT; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; DIET, REDUCING; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES; TIME FACTORS; TRYPTOPHAN;

EID: 36749081555     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/j.1399-5618.2007.00466.x     Document Type: Article

References (24)

1. Curzon G. Influence of plasma tryptophan on brain 5-HT synthesis and serotonergic activity. Adv Exp Med Biol 1981; 133: 207-219.
2. Tagliamonte A, Biggio G, Vargiu L, Gessa GL. Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sci II 1973; 12: 277-287.
3. Fernstrom JD, Larin F, Wurtman RJ. Correlations between brain tryptophan and plasma neutral amino acid levels following food consumption in rats. Life Sci 1973; 13: 517-524.
4. Young SN, Ervin FR, Pihl RO, Finn P. Biochemical aspects of tryptophan depletion in primates. Psychopharmacology (Berl) 1989; 98: 508-511.
5. Clemens JA, Bennett DR, Fuller RW. The effect of a tryptophan-free diet on prolactin and corticosterone release by serotonergic stimuli. Horm Metab Res 1980; 12: 35-38.
6. Gibbons JL, Barr GA, Bridger WH, Leibowitz SF. Manipulations of dietary tryptophan: Effects on mouse killing and brain serotonin in the rat. Brain Res 1979; 169: 139-153.
7. Lytle LD, Messing RB, Fisher L, Phebus L. Effects of long-term corn consumption on brain serotonin and the response to electric shock. Science 1975; 190: 692-694.
8. Moja EA, Mendelson WB, Stoff DM, Gillin JC, Wyatt RJ. Reduction of REM sleep by a tryptophan-free amino acid diet. Life Sci 1979; 24: 1467-1470.
9. Walters JK, Davis M, Sheard MH. Tryptophan-free diet: Effects on the acoustic startle reflex in rats. Psychopharmacology (Berl) 1979; 62: 103-109.
10. Delgado PL, Charney DS, Price LH, Landis H, Heninger GR. Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects. Life Sci 1989; 45: 2323-2332.
11. Harper AE, Benevenga NJ, Wohlhueter RM. Effects of ingestion of disproportionate amounts of amino acids. Physiol Rev 1970; 50: 428-558.
12. Young SN, Smith SE, Pihl RO, Ervin FR. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology (Berl) 1985; 87: 173-177.
13. Young SN. The use of diet and dietary components in the study of factors controlling affect in humans: A review. J Psychiatry Neurosci 1993; 18: 235-244.
14. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 1990; 47: 411-418.
15. Delgado PL, Moreno FA. Role of norepinephrine in depression. J Clin Psychiatry 2000; 61 (Suppl. 1): 5-12.
16. Moller SE, Amdisen A. Plasma neutral amino acids in mania and depression: Variation during acute and prolonged treatment with L-tryptophan. Biol Psychiatry 1979; 14: 131-139.
17. Benkelfat C, Seletti B, Palmour RM, Hillel J, Ellenbogen M, Young SN. Tryptophan depletion in stable lithium-treated patients with bipolar disorder in remission. Arch Gen Psychiatry 1995; 52: 154-156.
18. Cappiello A, Sernyak MJ, Malison RT, McDougle CJ, Heninger GR, Price LH. Effects of acute tryptophan depletion in lithium-remitted manic patients: A pilot study. Biol Psychiatry 1997; 42: 1076-1078.
19. Cassidy F, Murry E, Carroll BJ. Tryptophan depletion in recently manic patients treated with lithium. Biol Psychiatry 1998; 43: 230-232.
20. Hughes JH, Dunne F, Young AH. Effects of acute tryptophan depletion on mood and suicidal ideation in bipolar patients symptomatically stable on lithium. Br J Psychiatry 2000; 177: 447-451.
21. Shiah IS, Yatham LN. Serotonin in mania and in the mechanism of action of mood stabilizers: A review of clinical studies. Bipolar Disord 2000; 2: 77-92.
22. Prange AJ Jr, Wilson IC, Lynn CW, Alltop LB, Stikeleather RA. L-tryptophan in mania. Contribution to a permissive hypothesis of affective disorders. Arch Gen Psychiatry 1974; 30: 56-62.
23. Biederman J, Lerner Y, Belmaker RH. Combination of lithium carbonate and haloperidol in schizo-affective disorder: A controlled study. Arch Gen Psychiatry 1979; 36: 327-333.
24. Klein E, Bental E, Lerer B, Belmaker RH. Carbamazepine and haloperidol v placebo and haloperidol in excited psychoses. A controlled study. Arch Gen Psychiatry 1984; 41: 165-170.