Non-invasive grading of brain tumours using dynamic amino acid PET imaging: Does it work for 11C-Methionine?

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 34, Issue 12, 2007, Pages 2082-2087

  Moulin Romsée, Gérard ^a   D'Hondt, Eduard ^a   De Groot, Tjibbe ^a,b   Goffin, Jan ^a   Sciot, Raf ^a   Mortelmans, Luc ^a   Menten, Johan ^a   Bormans, Guy ^b   Van Laere, Koen ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

11C methionine; Brain tumour; Dynamic analysis; Grading; PET

Indexed keywords

AMINO ACID; METHIONINE C 11;

ADULT; AGED; ARTICLE; BRAIN METABOLISM; BRAIN TUMOR; CANCER GRADING; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MEDICAL PARAMETERS; NON INVASIVE MEASUREMENT; POSITRON EMISSION TOMOGRAPHY; RETROSPECTIVE STUDY; SCHOOL CHILD; TUMOR DIAGNOSIS;

ADOLESCENT; ADULT; BRAIN NEOPLASMS; CHILD; FEMALE; GLIOMA; HUMANS; MALE; METHIONINE; NEOPLASM STAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 36749070855     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-007-0557-4     Document Type: Article

References (11)

1. Stupp R, Hegi ME, van den Bent MJ, et al. Changing paradigms-an update on the multidisciplinary management of malignant glioma. Oncologist 2006;11:165-80.
2. Riemann B, Papke K, Hoess N, et al. Noninvasive grading of untreated gliomas: a comparative study of MR imaging and 3-(iodine 123)-L-alpha- methyltyrosine SPECT. Radiology 2002;225:567-74.
3. Jacobs AH, Kracht LW, Gossmann A, et al. Imaging in neurooncology. NeuroRx 2005;2:333-47.
4. Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ, Piers DA. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 2001;42:432-45.
5. Ceyssens S, Van Laere K, de Groot T, Goffin J, Bormans G, Mortelmans L. [11C]methionine PET, histopathology, and survival in primary brain tumors and recurrence. AJNR Am J Neuroradiol 2006;27:1432-37.
6. Weber WA, Dick S, Reidl G, et al. Correlation between postoperative 3-[(123)I]iodo-L-alpha-methyltyrosine uptake and survival in patients with gliomas. J Nucl Med 2001;42:1144-150.
7. Popperl G, Kreth FW, Herms J, et al. Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods? J Nucl Med 2006;47:393-403.
8. Weckesser M, Langen KJ, Rickert CH, et al. O-(2-[18F]fluorethyl)-L- tyrosine PET in the clinical evaluation of primary brain tumours. Eur J Nucl Med Mol Imaging 2005;32:422-9.
9. Meier C, Ristic Z, Klauser S, Verrey F. Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J 2002;21:580-9.
10. Stober B, Tanase U, Herz M, Seidl C, Schwaiger M, Senekowitsch-Schmidtke R. Differentiation of tumour and inflammation: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells. Eur J Nucl Med Mol Imaging 2006;33:932-9.
11. Wester HJ, Herz M, Weber W, et al. Synthesis and radiopharmacology of O-(2-[18F]fluoroethyl)-L-tyrosine for tumor imaging. J Nucl Med 1999;40:205-12.