The key virulence-associated genes of Streptococcus suis type 2 are upregulated and differentially expressed in vivo

FEMS Microbiology Letters

Volumn 278, Issue 1, 2008, Pages 108-114

  Tan, Chen ^a   Liu, Manli ^a   Jin, Meilin ^a   Liu, Jinlin ^a   Chen, Yan ^a   Wu, Tao ^a   Fu, Ting ^a   Bei, Weicheng ^a   Chen, Huanchun ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

Differential expression; Real time PCR; Streptococcus suis serotype 2; Virulence associated genes

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; EF PROTEIN; FBPS PROTEIN; GAPDH PROTEIN; HYL PROTEIN; MULTIDRUG RESISTANCE PROTEIN; SLY PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BLOOD; BRAIN; CELL CULTURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOCOCCUS SUIS; UPREGULATION;

ANIMALS; BACTERIAL PROTEINS; DNA, BACTERIAL; GENE EXPRESSION PROFILING; HELA CELLS; HUMANS; SEROTYPING; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS SUIS; SWINE; SWINE DISEASES; UP-REGULATION; VIRULENCE; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS SUIS; SUIDAE;

EID: 36749065601     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2007.00980.x     Document Type: Article

References (27)

1. Arends JP Zanen HC (1988) Meningitis caused by Streptococcus suis in humans. Rev Infect Dis 10 : 131 137.
2. Benga L, Friedl P Valentin-Weigand P (2005) Adherence of Streptococcus suis to porcine endothelial cells. J Vet Med 52 : 392 395.
3. Boulnois GJ, Paton JC, Mitchell TJ Andrew PW (1991) Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pnelumoniae. Mol Microbiol 5 : 2611 2616.
4. Brassard J, Gottschalk M Quessy S (2004) Cloning and purification of the Streptococcus suis serotype 2 glyceraldehyde-3-phosphate dehydrogenase and its involvement as an adhesin. Vet Res 102 : 87 94.
5. de Greeff A, Buys H, Verhaar R, Dijkstra J, van Alphen L Smith HE (2002) Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2. Infect Immun 70 : 1319 1325.
6. Gase K, Gase A, Schirmer H Malke H (1996) Cloning, sequencing and functional overexpression of the Streptococcus equisimilis H46A gapC gene encoding a glyceraldehyde-3-phosphate dehydrogenase that also functions as a plasmin(ogen)-binding protein. Purification and biochemical characterization of the protein. Eur J Biochem 239 : 42 51.
7. Gottschalk M, Higgins R Quessy S (1999) Dilemma of the virulence of Streptococcus suis strains. J Clin Microbiol 37 : 4202 4203.
8. Heidt MC, Mohamed W, Hain T, Vogt PR, Chakraborty T Domann E (2005) Human infective endocarditis caused by Streptococcus suis serotype 2. J Clin Microbiol 43 : 4898 4901.
9. Hynes WL Walton SL (2000) Hyaluronidases of gram-positive bacteria. FEMS Microbiol Lett 183 : 201 207.
10. Jacobs AAC, Loeffen PLW, Berg AJG Storm PK (1994) Identification, purification, and characterization of a thiol-activated hemolysin (suilysin) of Streptococcus suis. Infect Immun 62 : 1742 1748.
11. Jacobs AAC, Berg AJG, Baars JC, Nielsen B Johannsen LW (1995) Production of suilysin, the thiol-activated haemolysin of Streptococcus suis, by field isolates from diseased pigs. Vet Rec 137 : 295 296.
12. Joh D, Wann ERW, Kreikemeyer B, Speziale P Hook M (1999) Role of fibronectin-binding MSCRAMMS in bacterial adherence and entry into mammalian cells. Matrix Biol 18 : 211 223.
13. King SJ, Heath PJ, Luque I et al 2001) Distribution and genetic diversity of suilysin in Streptococcus suis isolated from different disease of pigs and characterization of the genetic basis of suilysin absence. Infect Immun 69 : 7572 7582.
14. King SJ, Allen AG, Maskell DJ, Dowson CG Whatmore AM (2004) Distribution, genetic diversity, and variable expression of the gene encoding hyaluronate lyase within the Streptococcus suis population. J Bacteriol 186 : 4740 4747.
15. Lalonde M, Segura M, Lacouture S Gottschalk M (2000) Interactions between Streptococcus suis serotype 2 and different epithelial cell lines. Microbiology 146 : 1913 1921.
16. Laurent TC Fraser JRE (1992) Hyaluronan. FASEB J 6 : 2397 2404.
17. LeMessurier KS, Ogunniyi AD Paton JC (2006) Differential expression of key pneumococcal virulence genes in vivo. Microbiology 152 : 305 311.
18. Marciel AM, Kapur V Musser JM (1997) Molecular population genetic analysis of a Streptococcus pyogenes bacteriophage-encoded hyaluronidase: gene recombination contributes to allelic variation. Microb Pathog 22 : 209 217.
19. Marie-Claude J, Brassard J, Quessy S, Gottschalk M Grenierl D (2004) Acquisition of host plasmin activity by the swine pathogen Streptococcus suis serotype 2. Infect Immun 72 : 606 610.
20. Ogunniyi AD, Giammarinaro P Paton JC (2002) The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148 : 2045 2053.
21. Pancholi BV Fischetti VA (1997) Cell-to-cell signalling between group A streptococci and pharyngeal cells. Role of streptococcal surface dehydrogenase (SDH). Adv Exp Med Biol 418 : 499 504.
22. Shichun L, Perez-Casal J, Connor W Willson PJ (2003) Role of suilysin in pathogenesis of Streptococcus suis capsular serotype 2. Microb Pathog 34 : 27 37.
23. Smith HE, Vecht U, Gielkens ALJ Smiths MA (1992) Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2. Infect Immun 60 : 2361 2367.
24. Vecht U, Wisselink HJ, Jellema ML Smith HE (1991) Identification of two proteins associated with virulence of Streptococcus suis type 2. Infect Immun 59 : 3156 3162.
25. Wisselink HJ, Vecht U, Stockhofe-Zurwieden N Smith HE (2001) Protection of pigs against challenge with virulent Streptococcus suis serotype 2 strains by a muramidase-released protein and extracellular factor vaccine. Vet Rec 148 : 473 477.
26. Yu H, Jing H, Chen Z et al 2006) Human Streptococcus suis outbreak, Sichuan, China. Emerg Infect Dis 12 : 914 920.
27. Zhu H, He J, Jing HB, Wang ZQ Duan Q (2006) Isolation and identification of Streptococcus suis serotype 2 from sick-pig samples of Sichuan province. Wei Sheng Wu Xue Bao 46 : 635 638.