Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 1, 2008, Pages 64-71

  Colantuono, Giuseppe ^a   Tiravanti, Edy Altea ^a   Di Venosa, Nicola ^a   Cazzato, Antonia ^a   Rastaldo, Raffaella ^b   Cagiano, Raffaele ^a   D'Agostino, Donato ^a   Federici, Antonio ^a   Fiore, Tommaso ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Cardioprotection; Heart; Hyperoxia; Infarct; Mechanical ventilation; Oxygen; Preconditioning; Reperfusion injury

Indexed keywords

5 HYDROXYDECANOIC ACID; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; FREE RADICAL; GLIBENCLAMIDE; OXYGEN; REACTIVE OXYGEN METABOLITE;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BLOOD PRESSURE MEASUREMENT; CARBON DIOXIDE TENSION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART MUSCLE TENSION; HEART PROTECTION; HEART RATE; HYPEROXIA; ISOLATED HEART; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY;

ACETYLCYSTEINE; ANIMALS; ANOXIA; BLOOD PRESSURE; CORONARY CIRCULATION; DECANOIC ACIDS; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; GLYBURIDE; HEART RATE; HYDROXY ACIDS; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATIVE STRESS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RESPIRATION, ARTIFICIAL; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 36649019539     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04745.x     Document Type: Article

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