Fragrance material review on ethyl cinnamate

Food and Chemical Toxicology

Volumn 45, Issue 1 SUPPL., 2007, Pages

  Bhatia, S P ^a   Wellington, G A ^a   Cocchiara, J ^b   Lalko, J ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

^b Manheimer Fragrances ^*  (United States)

Author keywords

Ethyl cinnamate; Fragrance; Review

Indexed keywords

CINNAMIC ACID DERIVATIVE; ETHYLCINNAMATE; FRAGRANCE; UNCLASSIFIED DRUG;

ABSORPTION; ACUTE TOXICITY; BACTERIUM; CARCINOGENICITY; CHRONIC TOXICITY; EXPERIMENTAL STUDY; EYE IRRITATION; GENOTOXICITY; HEALTH STATUS; HUMAN; MAMMAL; METABOLISM; MUCOSA; MUTAGENICITY; NONHUMAN; PHOTOALLERGY; PHOTOTOXICITY; PHYSICAL CHEMISTRY; REVIEW; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; TISSUE DISTRIBUTION; TOXICOLOGY;

ANIMALS; CHO CELLS; CINNAMATES; CONSUMER PRODUCT SAFETY; CRICETINAE; CRICETULUS; HUMANS; IRRITANTS; MUTAGENICITY TESTS; MUTAGENS; PERFUME; RISK ASSESSMENT; SKIN; SKIN ABSORPTION; SKIN IRRITANCY TESTS; SKIN TESTS;

EID: 36549090496     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.09.021     Document Type: Review

References (21)

1. Ames B.N., McCann J., and Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31 (1975) 347-363
2. Bar V.F., and Griepentrog F. Die Situation in der gesundheitlichen Beurteilung der Aromatisierungsmittel fur Lebensmittel. Medizin Ernahr. 8 (1967) 244-251
3. Belsito D., Bickers D., Bruze M., Calow P., Greim H., Hanifin J.H., Rogers A.E., Saurat J.H., Sipes I.G., and Tagami H. A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients. Food and Chemical Toxicology 45 1S1 (2007) S1-S23
4. Council of Europe, 2000. Partial Agreement in the Social and Public Health Field, Chemically-defined Flavouring Substances, Group 9.5.5 Esters of Aromatic Acid. Cinnamates, Council of Europe Publishing, Strasbourg, number 323, p. 383.
5. FDA (Food and Drug Administration). Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, Volume 3, Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants.
6. FEMA (Flavor and Extract Manufacturers Association). Recent progress in the consideration of flavoring ingredients under the food additives amendment III. GRAS substances. Food Technol. 19 2, part 2 (1965) 151-197
7. IFRA (International Fragrance Association), 2001. Use Level Survey, July 2001.
8. JECFA (Joint Expert Committee on Food Additives), 2000. Safety Evaluation of Certain Food Additives. Who Food Additives Series: 46. Prepared by the 55th Meeting of the Joint FAO/WHO Expert Committee on Food Additives, World Health Organization, Geneva 2000.
9. Ishidate Jr. M., Sofuni T., Yoshikawa K., Hayashi M., Nohmi T., Sawada M., and Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem. Toxicol. 22 (1984) 623-636
10. Katz A.E. Dermal irritating properties of essential oils and aromatic chemicals. The Spice Mill 69 (1946) 46-48
11. Klecak, G., 1979. The Open Epicutaneous Test (OET), A Predictive Test Procedure in the Guinea Pig for Estimation of Allergenic Properties of Simple Chemical Compounds, Their Mixtures and of Finished Cosmetic Preparations, International Federation Societies Cosmetic Chemists, 9/18/79.
12. Klecak G. The Freund's complete adjuvant test and the open epicutaneous test. Curr. Probl. Dermatol. 14 (1985) 152-171
13. Kligman A.M. The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. Invest. Dermatol. 47 (1966) 393-409
14. Kligman A.M., and Epstein W. Updating the maximization test for identifying contact allergens. Contact Dermat. 1 (1975) 231-239
15. Moro F., Sparatore F., and Piccinini R. Phacotoxic action of alpha, beta-unsaturated carboxylic substances and beta-napthyl derivatives (experimental study). Ann. Ottalmol. clin. Ocul. 95 (1969) 935-944
16. Oda, Y., Hamono, Y., Inoue, K., Yamamoto, H., Niihara, T., Kunita, N., 1978. Mutagenicity of Food Flavors in Bacteria (1st Report), Shokuhin Eisei Hen 9, pp. 177-181.
17. RIFM (Research Institute for Fragrance Materials, Inc.), 1958. Toxicological Screening of Components of Food Flavors. Class IV Cinnamates. [Private communication to FEMA]. Unpublished Report from Trubek Laboratories Inc., Report Number 27593 (RIFM, Woodcliff Lake, NJ, USA).
18. RIFM (Research Institute for Fragrance Materials, Inc.), 1973a. Acute Oral and Dermal Toxicity Studies, RIFM Report Number 2033, March 06 (RIFM, Woodcliff Lake, NJ, USA).
19. RIFM (Research Institute for Fragrance Materials, Inc.), 1973b. Report on Human Maximization Studies. RIFM Report Number 1802, July 27 (RIFM, Woodcliff Lake, NJ, USA).
20. Sasaki Y.F., Imanishi H., Ohta T., and Shirasu Y. Modifying effects of components of plant essence on the induction of sister-chromatid exchanges in cultured Chinese hamster ovary cells. Mutat. Res. 226 (1989) 103-110
21. Zaitsev A.N., and Rakhmanina N.L. Some data on the toxic properties of phenylethanol and cinnamic alcohols. Vopr. Pitaniya 6 (1974) 48-53