Alternative splicing of c-fos pre-mRNA: Contribution of the rates of synthesis and degradation to the copy number of each transcript isoform and detection of a truncated c-Fos immunoreactive species

BMC Molecular Biology

Volumn 8, Issue , 2007, Pages

  Jurado, Juan ^a   Fuentes Almagro, Carlos A ^a   Prieto Álamo, María J ^a   Pueyo, Carmen ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN C FOS; PROTEIN C FOS 2; TRANSCRIPTION FACTOR DELTA FOSB; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR FRA 2; UNCLASSIFIED DRUG; ISOPROTEIN; RNA PRECURSOR;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INTRON; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; CELL LINE; EXON; GENE EXPRESSION; GENETICS; IMMUNOLOGY; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; ONCOGENE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MAMMALIA;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CELL LINE; EXONS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, FOS; IMMUNOPRECIPITATION; INTRONS; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-FOS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PRECURSORS; TRANSCRIPTION, GENETIC;

EID: 36549086727     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-8-83     Document Type: Article

References (36)

1. Hess J Angel P Schorpp-Kistner M AP-1 subunits: Quarrel and harmony among siblings J Cell Sci 2004, 117(Pt 25):5965-5973 10.1242/jcs.01589 15564374
2. Milde-Langosch K The Fos family of transcription factors and their role in tumourigenesis Eur J Cancer 2005, 41(16):2449-2461 10.1016/ j.ejca.2005.08.008 16199154
3. Greenberg ME Greene LA Ziff EB Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells J Biol Chem 1985, 260(26):14101-14110 3877054
4. Curran T Miller AD Zokas L Verma IM Viral and cellular fos proteins: A comparative analysis Cell 1984, 36(2):259-268 10.1016/ 0092-8674(84)90219-8 6319013
5. Rahmsdorf HJ Schonthal A Angel P Litfin M Ruther U Herrlich P Posttranscriptional regulation of c-fos mRNA expression Nucleic Acids Res 1987, 15(4):643-1659 340572 3103102 10.1093/nar/15.4.1643
6. Cahill MA c-Fos transrepression revisited FEBS Lett 1997, 400(1):9-10 10.1016/S0014-5793(96)01349-X 9000503
7. Taneri B Snyder B Novoradovsky A Gaasterland T Alternative splicing of mouse transcription factors affects their DNA-binding domain architecture and is tissue specific Genome Biol 2004, 5(10):R75 545595 15461794 10.1186/gb-2004-5-10-r75
8. Sherwood DR Butler JA Kramer JM Sternberg PW FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans Cell 2005, 121(6):951-962 10.1016/j.cell.2005.03.031 15960981
9. Nakabeppu Y Nathans D A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity Cell 1991, 64(4):751-759 10.1016/0092-8674(91)90504-R 1900040
10. Yen J Wisdom RM Tratner I Verma IM An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins Proc Natl Acad Sci U S A 1991, 88(12):5077-5081 51814 1905017 10.1073/pnas.88.12.5077
11. Mumberg D Lucibello FC Schuermann M Muller R Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins Genes Dev 1991, 5(7):1212-1223 10.1101/gad.5.7.1212 1648531
12. Feng Z Kong LY Qi Q Ho SL Tiao N Bing G Han YF Induction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharide Neurosci Lett 2001, 305(1):17-20 10.1016/ S0304-3940(01)01793-1 11356297
13. Shur I Socher R Benayahu D Dexamethasone regulation of cFos mRNA in osteoprogenitors J Cell Physiol 2005, 202(1):240-245 10.1002/jcp.20113 15389524
14. Jiménez A Prieto-Álamo MJ Fuentes-Almagro CA Jurado J Gustafsson JA Pueyo C Miranda-Vizuete A Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins Biochem Biophys Res Commun 2005, 330(1):65-74 10.1016/j.bbrc.2005.02.128 15781233
15. Jurado J Prieto-Alamo MJ Madrid-Risquez J Pueyo C Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouse J Biol Chem 2003, 278(46):45546-45554 10.1074/jbc.M307866200 12954614
16. Prieto-Álamo MJ Cabrera-Luque JM Pueyo C Absolute quantitation of normal and ROS-induced patterns of gene expression: An in vivo real-time PCR study in mice Gene Expr 2003, 11(1):23-34 12691523
17. Ruiz-Laguna J Abril N García-Barrera T Gómez-Ariza JL Lopez-Barea J Pueyo C Absolute transcript expression signatures of Cyp and Gst genes in Mus spretus to detect environmental contamination Environ Sci Technol 2006, 40(11):3646-3652 10.1021/es060056e 16786706
18. Monje-Casas F Michan C Pueyo C Absolute transcript levels of thioredoxin- and glutathione-dependent redox systems in Saccharomyces cerevisiae: Response to stress and modulation with growth Biochem J 2004, 383(Pt 1):139-147 1134052 15222878
19. Greenberg ME Hermanowski AL Ziff EB Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription Mol Cell Biol 1986, 6(4):1050-1057 367614 2431274
20. Coronella-Wood J Terrand J Sun H Chen QM c-Fos phosphorylation induced by H2O2 prevents proteasomal degradation of c-Fos in cardiomyocytes J Biol Chem 2004, 279(32):33567-33574 10.1074/jbc.M404013200 15136564
21. McClung CA Ulery PG Perrotti LI Zachariou V Berton O Nestler EJ ΔFosB: A molecular switch for long-term adaptation in the brain Brain Res Mol Brain Res 2004, 132(2):146-154 10.1016/ j.molbrainres.2004.05.014 15582154
22. Shyu AB Greenberg ME Belasco JG The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways Genes Dev 1989, 3(1):60-72 10.1101/gad.3.1.60 2496006
23. Grosset C Chen CY Xu N Sonenberg N Jacquemin-Sablon H Shyu AB A mechanism for translationally coupled mRNA turnover: Interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex Cell 2000, 103(1):29-40 10.1016/S0092-8674(00)00102-1 11051545
24. Wilkinson MF A new function for nonsense-mediated mRNA-decay factors Trends Genet 2005, 21(3):143-148 10.1016/j.tig.2005.01.007 15734573
25. Lejeune F Maquat LE Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells Curr Opin Cell Biol 2005, 17(3):309-315 10.1016/j.ceb.2005.03.002 15901502
26. Moraes KC Wilusz CJ Wilusz J CUG-BP binds to RNA substrates and recruits PARN deadenylase Rna 2006, 12(6):1084-1091 1464848 16601207 10.1261/ rna.59606
27. Xu N Chen CY Shyu AB Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay Mol Cell Biol 1997, 17(8):4611-4621 232314 9234718
28. Miao GG Curran T Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle Mol Cell Biol 1994, 14(6):4295-4310 358796 8196666
29. Schuermann M Neuberg M Hunter JB Jenuwein T Ryseck RP Bravo R Muller R The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation Cell 1989, 56(3):507-516 10.1016/0092-8674(89)90253-5 2492453
30. Ferrara P Andermarcher E Bossis G Acquaviva C Brockly F Jariel-Encontre I Piechaczyk M The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression Oncogene 2003, 22(10):1461-1474 10.1038/sj.onc.1206266 12629509
31. Murphy LO Smith S Chen RH Fingar DC Blenis J Molecular interpretation of ERK signal duration by immediate early gene products Nat Cell Biol 2002, 4(8):556-564 12134156
32. Kohler JJ Schepartz A Kinetic studies of Fos•Jun•DNA complex formation: DNA binding prior to dimerization Biochemistry 2001, 40(1):130-142 10.1021/bi001881p 11141063
33. Nakabeppu Y Ryder K Nathans D DNA binding activities of three murine Jun proteins: Stimulation by Fos Cell 1988, 55(5):907-915 10.1016/ 0092-8674(88)90146-8 3142691
34. Zondlo NJ Schepartz A Highly specific DNA recognition by a designed miniature protein J Am Chem Soc 1999, 121:6938-6939 10.1021/ja990968z
35. Pueyo C Jurado J Prieto-Alamo MJ Monje-Casas F Lopez-Barea J Multiplex reverse transcription-polymerase chain reaction for determining transcriptional regulation of thioredoxin and glutaredoxin pathways Methods Enzymol 2002, 347:441-451 11898436
36. Michán C Monje-Casas F Pueyo C Transcript copy number of genes for DNA repair and translesion synthesis in yeast: Contribution of transcription rate and mRNA stability to the steady-state level of each mRNA along with growth in glucose-fermentative medium DNA Repair (Amst) 2005, 4(4):469-478 10.1016/j.dnarep.2004.12.001 15725627