BEAC or BEAM high-dose chemotherapy followed by autologous stem cell transplantation in non-Hodgkin's lymphoma patients: Comparative analysis of efficacy and toxicity

Annals of Hematology

Volumn 87, Issue 1, 2008, Pages 43-48

  Jo, Jae Cheol ^a   Kang, Byung Wook ^a   Jang, Geundoo ^a   Sym, Sun Jin ^a   Lee, Sung Sook ^a   Koo, Ja Eun ^a   Kim, Jong Wook ^a   Kim, Shin ^a   Huh, Jooryung ^b   Suh, Cheolwon ^a  

^a Asan Medical Center   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

Autologousstem cell transplantation; BEAC; BEAM; Non Hodgkin's lymphoma; Survival; Toxicity

Indexed keywords

ANTIINFECTIVE AGENT; CARMUSTINE; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; MELPHALAN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLEEDING; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; DRUG SAFETY; ERYTHROCYTE TRANSFUSION; FEBRILE NEUTROPENIA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NAUSEA; NEUTROPHIL; NONHODGKIN LYMPHOMA; OPPORTUNISTIC INFECTION; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SEPTICEMIA; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTE TRANSFUSION;

ADOLESCENT; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARMUSTINE; CYCLOPHOSPHAMIDE; CYTARABINE; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LYMPHOMA, NON-HODGKIN; MALE; MELPHALAN; MIDDLE AGED; PODOPHYLLOTOXIN; RETROSPECTIVE STUDIES; SURVIVAL RATE; TRANSPLANTATION, AUTOLOGOUS;

EID: 36549080513     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-007-0360-0     Document Type: Article

References (24)

1. Philip T, Armitage JO, Spitzer G et al (1987) High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. N Engl J Med 316:1493-1498
2. Philip T, Guglielmi C, Hagenbeek A et al (1995) Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med 333:1540-1545
3. Blay J, Gomez F, Sebban C et al (1998) The International Prognostic Index correlates to survival in patients with aggressive lymphoma in relapse: Analysis of the PARMA trial. Blood 92:3562-3568
4. Milpied N, Deconinck E, Gaillard F et al (2004) Initial treatment of aggressive lymphoma with high-dose chemotherapy and autologous stem-cell support. N Engl J Med 350:1287-1295
5. The International Non-Hodgkin's Lymphoma Prognostic Factors Project (1993) A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med 329:987-994
6. Shipp MA, Abeloff MD, Antman KH et al (1999) International consensus conference on high-dose therapy with hematopoietic stem cell transplantation in aggressive non-Hodgkin's lymphomas: Report of the jury. J Clin Oncol 17:423-429
7. Mounier N, Gisselbrecht C (1998) Conditioning regimens before transplantation in patients with aggressive non-Hodgkin's lymphoma. Ann Oncol 9(Suppl 1):S15-S21
8. Salar A, Sierra J, Gandarillas M et al (2001) Autologous stem cell transplantation for clinically aggressive non-Hodgkin's lymphoma: The role of preparative regimens. Bone Marrow Transplant 27:405-412
9. Caballero MD, Rubio V, Rifon J et al (1997) BEAM chemotherapy followed by autologous stem cell support in lymphoma patients: Analysis of efficacy, toxicity and prognostic factors. Bone Marrow Transplant 20:451-458
10. Buser AS, Stern M, Bucher C et al (2007) High-dose chemotherapy using BEAM without autologous rescue followed by reduced-intensity conditioning allogeneic stem-cell transplantation for refractory or relapsing lymphomas: A comparison of delayed versus immediate transplantation. Bone Marrow Transplant 39:335-340
11. Argiris A, Seropian S, Cooper DL (2000) High-dose BEAM chemotherapy with autologous peripheral blood progenitor-cell transplantation for unselected patients with primary refractory or relapsed Hodgkin's disease. Ann Oncol 11:665-672
12. Buadi FK, Micallef IN, Ansell SM et al (2006) Autologous hematopoietic stem cell transplantation for older patients with relapsed non-Hodgkin's lymphoma. Bone Marrow Transplant 37:1017-1022
13. Weaver CH, Schwartzberg L, Zhen B et al (1997) High-dose chemotherapy and peripheral blood stem cell infusion in patients with non-Hodgkin's lymphoma: Results of outpatient treatment in community cancer centers. Bone Marrow Transplant 20:753-760
14. Jantunen E, Itala M, Juvonen E et al (2006) Autologous stem cell transplantation in elderly (>60 years) patients with non-Hodgkin's lymphoma: A nation-wide analysis. Bone Marrow Transplant 37:367-372
15. Cheson BD, Horning SJ, Coiffier B et al (1999) Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. J Clin Oncol 17:1244-1253
16. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
17. Peto R, Peto J (1972) Asymptotically efficient rank invariant test procedures. JR Stat Soc 135:185-206
18. Jantunen E, Kuittinen T, Nousiainen T (2003) BEAC or BEAM for high-dose therapy in patients with non-Hodgkin's lymphoma? A single centre analysis on toxicity and efficacy. Leuk Lymphoma 44:1151-1158
19. Wang EH, Chen YA, Corringham S et al (2004) High-dose CEB vs BEAM with autologous stem cell transplant in lymphoma. Bone Marrow Transplant 34:581-587
20. Mills W, Chopra R, McMillan A et al (1995) BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin's lymphoma. J Clin Oncol 13:588-595
21. Samuels BL, Bitran JD (1995) High-dose intravenous melphalan: A review. J Clin Oncol 13:1786-1799
22. Hamlin PA, Zelenetz AD, Kewalramani T et al (2003) Age-adjusted International Prognostic Index predicts autologous stem cell transplantation outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma. Blood 102:1989-1996
23. Rodriguez J, Caballero MD, Gutierrez A et al (2003) High dose chemotherapy and autologous stem cell transplantation in patients with peripheral T-cell lymphoma not achieving complete response after induction chemotherapy. The GEL-TAMO experience. Haematologica 88:1372-1377
24. Kim MK, Kim S, Lee SS et al (2007) High-dose chemotherapy and autologous stem cell transplantation for peripheral T-cell lymphoma: Complete response at transplant predicts survival. Ann Hematol 86:435-442