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Volumn , Issue 18, 2007, Pages 2833-2836

[RuCl3(H2O)n]-catalyzed direct arylations with bromides as electrophiles

Author keywords

Arene; Aryl bromides; C H bond functionalization; Regioselectivity; Ruthenium

Indexed keywords

BROMIDE; RUTHENIUM DERIVATIVE;

EID: 36549071920     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-990838     Document Type: Article
Times cited : (98)

References (38)
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    • For [Pd]: (f) Miura, M.; Satoh, T. In Topics in Organometallic Chemistry, Vol. 14; Tsuji, J., Ed.; Springer: Berlin/Heidelberg/New York, 2005, 55-83.
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    • For a review on the use of secondary phosphine oxides in catalysis, see
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  • 38
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    • Representative Procedure, Synthesis of 3d (Table 1, Entry 3) A suspension of 5 (12.6 mg, 0.05 mmol, 5.0 mol, K2CO 3 (415 mg, 3.00 mmol, 2-phenylpyridine (160 mg, 1.03 mmol, and 4-bromoacetophenone (438 mg, 2.20 mmol) in anhyd NMP (2.0 mL) was stirred for 22 h at 120°C under N2. After the reaction mixture was cooled to ambient temperature, Et2O (50 mL) and H2O (40 mL) were added. The separated aqueous phase was extracted with Et2O (3 x 50 mL, The combined organic layers were washed with H2O (50 mL) and brine (50 mL, dried over Na2SO4, and concentrated in vacuo. The remaining residue was purified by column chromatography on silica gel (n-pentane-Et2O, 3:1 → 2:1 → 1:1 → 1:2 → 1:3) to yield 3d (361 mg, 90, mp 200.5-201.5°C) as a yellow solid. 1H NMR (300 MHz, CDCl3, δ, 8.30 d, J
    • 2: 391.1572; found: 391.1550.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.