α,β-Dehydrophenylalanine choline esters, a new class of reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase

Chemico-Biological Interactions

Volumn 171, Issue 1, 2008, Pages 108-116

  Grigoryan, Hasmik A ^a   Hambardzumyan, Artur A ^a   Mkrtchyan, Marina V ^b   Topuzyan, Vigen O ^b   Halebyan, Ghukas P ^a   Asatryan, Ruben S ^c  

^a CJSC Scientific Research Institute of Biotechnology   (Armenia)

^b Institute of Fine Organic Chemistry   (Armenia)

^c YEREVAN STATE MEDICAL UNIVERSITY   (Armenia)

Author keywords

Anticholinesterases; Cholinesterase inhibitors; Dehydroamino acid derivatives

Indexed keywords

ACETYLCHOLINESTERASE; ALPHA,BETA DEHYDROPHENYLALANINE CHOLINE ESTER DERIVATIVE; BENZENE; CHOLINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; ESTER DERIVATIVE; RIVASTIGMINE; SERINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; COMPUTER MODEL; CONTROLLED STUDY; COVALENT BOND; DRUG DESIGN; DRUG SYNTHESIS; ERYTHROCYTE; ESTERIFICATION; HUMAN;

ACETYLCHOLINESTERASE; BINDING, COMPETITIVE; BUTYRYLCHOLINESTERASE; CATALYSIS; CATALYTIC DOMAIN; CHOLINE; CHOLINESTERASE INHIBITORS; ESTERS; HUMANS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLALANINE;

EID: 36549071466     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.09.006     Document Type: Article

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