Fragrance material review on β-ionone

Food and Chemical Toxicology

Volumn 45, Issue 1 SUPPL., 2007, Pages

  Lalko, J ^a   Lapczynski, A ^a   McGinty, D ^a   Bhatia, S ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

Ionone; Fragrance; Review

Indexed keywords

BETA IONONE; FRAGRANCE;

ABSORPTION; ACUTE TOXICITY; CARCINOGENICITY; DERMATOLOGY; EYE IRRITATION; GENOTOXICITY; HUMAN; METABOLISM; MUCOSA INFLAMMATION; MUTAGENICITY; NONHUMAN; PHOTOALLERGY; PHOTOTOXICITY; REPRODUCTIVE TOXICITY; REVIEW; SKIN IRRITATION; SKIN SENSITIZATION; TOXICOLOGY;

ANIMALS; CONSUMER PRODUCT SAFETY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IRRITANTS; NORISOPRENOIDS; PERFUME; RISK ASSESSMENT; SKIN; SKIN IRRITANCY TESTS; SKIN TESTS; TERATOGENS; TOXICITY TESTS;

EID: 36549064193     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.09.052     Document Type: Review

References (25)

1. Bar V.F., and Griepentrog F. Die Situation in der gesundheitlichen Beurteilung der Aromatisierungsmittel fur Lebensmittel. Medizin Ernahr 8 (1967) 244-251
2. Belsito D., Bickers D., Bruze M., Calow P., Greim H., Hanifin J.H., Rogers A.E., Saurat J.H., Sipes I.G., and Tagami H. A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients. Food and Chemical Toxicology 45 1S1 (2007) S130-S167
3. Bielig H.J., and Hayasida A. Behavior of β-ionone in animals. Hoppe-Seyler's Zeitschrift fur Physiologische Chemie 266 (1940) 99-111
4. Buchbauer G., Jirovetz L., Jager W., Plank C., and Dietrich H. Fragrance compounds and essential oils with sedative effects upon inhalation. Journal of Pharmaceutical Science 82 (1993) 660-664
5. Council of Europe, 2000. Partial Agreement in the Social and Public Health Field. Chemically-defined Flavouring Substances. Group 7.1.4 cyclic terpene ketones, number 142. Council of Europe Publishing, Strasbourg, p. 155.
6. Draize J.H., Woodard G., and Calvery H.O. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. Journal of Pharmacology and Experimental Therapeutics 82 (1944) 377-390
7. Food and Drug Administration (FDA). Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, vol. 3, Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants.
8. Flavor and Extract Manufacturers Association (FEMA). Recent progress in the consideration of flavoring ingredients under the food additives amendment III. GRAS Substances. Food Technology 19 2, part 2 (1965) 151-197
9. Florin I., Rutberg L., Curvall M., and Enzell C.R. Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology 18 (1980) 219-232
10. Frosch P.J., Pilz B., Andersen K.E., Burrows D., Camarasa J.G., Dooms-Goossens A., Ducombs G., Fuchs T., Hannuksela M., Lachapelle J.M., Lahti A., Maibach H.I., Menne T., Rycroft R.J.G., Shaw S., Wahlberg J.E., White I.R., and Wilkinson J.D. Patch testing with fragrances: results of a multicenter study of the European environmental and contact dermatitis research group with 48 frequently used constituents of perfumes. Contact Dermatitis 33 (1995) 333-342
11. Gomes-Carneiro M.R., De-Oliveira A.C.A.X., De-Carvalho R.R., Araujo I.B., Souza C.A.M., Kuriyama S.N., and Paumgartten F.J.R. Inhibition of cyclophospamide-induced teratogenesis by β-ionone. Toxicology Letters 138 (2003) 205-213
12. Ide I., and Toki S. Metabolism of β-ionone. Isolation, characterization and identification of the metabolites in the urine of rabbits. Biochemical Journal 119 (1970) 281-287
13. International Fragrance Association (IFRA), 2002. Use Level Survey, August 2002.
14. Joint Expert Committee on Food Additives (JECFA), 1998. Safety evaluation of certain food additives. Who Food Additives Series: 42. Prepared by the Fifty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization, Geneva 1998.
15. Longenecker H.E., Musulin R.R., Tully III R.H., and King C.G. An acceleration of vitamin C synthesis and excretion by feeding known organic compounds to rats. Journal of Biological Chemistry 129 (1939) 445-453
16. Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., and Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environmental Mutagenesis 8 (1986) 1-119
17. Oser B.L., Carson S., and Oser M. Toxicological tests on flavouring matters. Food and Cosmetics Toxicology 3 (1965) 563-569
18. Pinching A.J., and Doving K.B. Selective degeneration in the rat olfactory bulb following exposure to different odours. Brain Research 82 (1974) 195-204
19. Prelog V., and Meier H.L. Organ extracts and urine. The biochemical oxidation of β-ionone in the animal body. Helvetica Chimica Acta 33 (1950) 1276-1285
20. Research Institute for Fragrance Materials, Inc. (RIFM), 1967a. Acute toxicity, eye and skin irritation test of fragrance materials. Unpublished report from Hoffmann-LaRoche, 20 September. Report number 30642, RIFM, Woodcliff Lake, NJ, USA.
21. Research Institute for Fragrance Materials, Inc. (RIFM), 1967b. Acute toxicity, eye and skin irritation test of fragrance materials. Unpublished report from Hoffmann-LaRoche, 16 November. Report number 30645, RIFM, Woodcliff Lake, NJ, USA.
22. Research Institute for Fragrance Materials, Inc. (RIFM), 1980. Short term toxicity study on β-ionone. Unpublished report from Givaudan, 19a May. Report number 43485, RIFM, Woodcliff Lake, NJ, USA.
23. Research Institute for Fragrance Materials, Inc. (RIFM), 1983. The short-term (90 day) toxicity of β-ionone in rats. Unpublished report from IOFI, 5 May. Report number 2496, RIFM, Woodcliff Lake, NJ, USA.
24. Research Institute for Fragrance Materials, Inc. (RIFM), 1999. Toxicology studies of β-ionone in the guinea pig. Unpublished report from Takasago International Corporation, 4 May. Report number 35056, RIFM, Woodcliff Lake, NJ, USA.
25. Willhite C.C. Structure-activity relationships of retinoids in developmental toxicology II. Influence of the polyene chain of the Vitamin A molecule. Toxicology and Applied Pharmacology 83 (1986) 563-575