Fragrance material review on benzyl cinnamate

Food and Chemical Toxicology

Volumn 45, Issue 1 SUPPL., 2007, Pages

  Bhatia, S P ^a   Wellington, G A ^a   Cocchiara, J ^b   Lalko, J ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

^b Manheimer Fragrances ^*  (United States)

Author keywords

Benzyl cinnamate; Fragrance; Review

Indexed keywords

CINNAMIC ACID BENZYL ESTER; CINNAMIC ACID DERIVATIVE; COSMETIC; DEODORANT AGENT; FRAGRANCE; SHAMPOO; UNCLASSIFIED DRUG;

BACTERIUM; CARCINOGENICITY; DEVELOPMENT; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG METABOLISM; EYE INFLAMMATION; GENOTOXICITY; HUMAN; INSECT; LD 50; LOTION; MAMMAL; MUCOSA INFLAMMATION; MUTAGENICITY; NONHUMAN; PHOTOALLERGY; PHOTOTOXICITY; REPRODUCTIVE TOXICITY; REVIEW; SKIN ABSORPTION; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY;

ADMINISTRATION, CUTANEOUS; ALLERGENS; ANIMALS; BENZYL COMPOUNDS; CINNAMATES; CONSUMER PRODUCT SAFETY; HUMANS; IRRITANTS; MUTAGENICITY TESTS; MUTAGENS; PERFUME; RISK ASSESSMENT; SKIN; SKIN ABSORPTION; SKIN IRRITANCY TESTS; SKIN TESTS;

EID: 36549058253     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.09.027     Document Type: Review

References (35)

1. Ames B.N., McCann J., and Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mut. Res. 31 (1975) 347-363
2. Bar V.F., and Griepentrog F. Die Situation in der gesundheitlichen Beurteilung der Aromatisierungsmittel fur Lebensmittel. Medizin Ernahr. 8 (1967) 244-251
3. Belsito D., Bickers D., Bruze M., Calow P., Greim H., Hanifin J.H., Rogers A.E., Saurat J.H., Sipes I.G., and Tagami H. A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients, 2007. Food Chem. Toxicol. 45 1S1 (2007) S1-S23
4. Council of Europe, 2000. Partial Agreement in the Social and Public Health Field. Chemically-defined Flavouring Substances. Group 9.5.5 Esters of Aromatic Acids. Cinnamate, page 385, number 331. Council of Europe Publishing, Strasbourg.
5. FDA (Food and Drug Administration). Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, vol. 3, Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants.
6. FEMA (Flavor and Extract Manufacturers Association), 1965. Recent progress in the consideration of flavoring ingredients under the food additives amendment III. GRAS Substances. Food Technol. 19(2, part 2), 151-197.
7. Florin I., Rutberg L., Curvall M., and Enzell C.R. Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology 15 (1980) 219-232
8. Gerberick G.F., Robinson M.K., Ryan C.A., Dearman R.J., Kimber I., Basketter D.A., Wright Z., and Marks J.G. Contact allergenic potency: correlation of human and local lymph node assay data. Amer. J. Contact Dermatitis 12 (2001) 156-161
9. Grundschober F. Toxicological assessment of flavouring esters. Toxicology 8 (1977) 387-390
10. Hagan E.C., Hansen W.H., Fitzhugh O.G., Jenner P.M., Jones W.I., Taylor J.M., Long E.L., Nelson A.A., and Brouwer J.B. Food flavourings and compounds of related structure II. Subacute and chronic toxicity. Food Cosmet. Toxicol. 5 (1967) 141-157
11. Hausen B.M., and Wollenweber E. Propolis allergy (III). Sensitization studies with minor constituents. Contact Dermatitis 19 (1988) 296-303
12. Hausen B.M., Simatupang T., Bruhn G., Evers P., and Koening W.A. Identification of new allergenic constituents and proof of evidence for coniferyl benzoate in Balsam of Peru. Amer. J. Contact Dermatitis 6 (1995) 199-208
13. Hjorth N. Other aromatic substances related to balsams. Eczematous Allergy to Balsams (1961), Munksgaard, Copenhagen pp. 94-111 (Chapter 10)
14. Hjorth N. Reactions to single components in balsam of Peru. Eczematous Allergy to Balsams (1961), Munksgaard, Copenhagen pp. 43-48 (Chapter 6)
15. Jenner P.M., Hagan E.C., Taylor J.M., Cook E.L., and Fitzhugh O.G. Food flavorings and compounds of related structure I. Acute oral toxicity. Food Cosmet. Toxicol. 2 (1964) 327-343
16. IFRA (International Fragrance Association), 2001. Use Level Survey, July 2001.
17. IFRA (International Fragrance Association), 2007. Code of Practice, Standard on Benzyl Cinnamate, Brussels.
18. JECFA (Joint Expert Committee on Food Additives), 2000. Safety evaluation of certain food additives. Who Food Additives Series: 46. Prepared by the Fifty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization, Geneva.
19. Klecak G., Geleick H., and Frey J.R. Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods. J. Soc. Cosmet. Chem. 28 (1977) 53-64
20. Klecak, G., 1979. The open epicutaneous test (OET), a predictive test procedure in the guinea pig for estimation of allergenic properties of simple chemical compounds, their mixtures and of finished cosmetic preparations. International Federation Societies Cosmetic Chemists, 9/18/79.
21. Kligman A.M. The identification of contact allergens by human assay III. The maximization test. A procedure for screening and rating contact sensitizers. J. Invest. Dermatol. 47 (1966) 393-409
22. Kligman A.M., and Epstein W. Updating the maximization test for identifying contact allergens. Contact Dermatitis 1 (1975) 231-239
23. Magnusson B., and Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermatol. 52 (1969) 268-276
24. Malten K.E., van Ketel H.W.G., Nater J.P., and Liem D.H. Contact allergische reacties met 22 reukgrondstoffen. Tijdschr. Soc. Geneesk. 61 (1983) 973-978
25. Malten K.E., van Ketel W.G., Nater J.P., and Leim D.H. Reactions in selected patients to 22 fragrance materials. Contact Dermatitis 11 (1984) 1-10
26. Meyer F., and Meyer E. Absorption of ethereal oils and substances contained in them through the skin. Arznei.-Forschung 9 (1959) 516-519
27. Meyer, R., 1965. Penetrating agents. British Patent 1,001,949, Cl. A61K 3/00,7/00, August 18. German Application July 20, 1961.
28. RIFM (Research Institute for Fragrance Materials Inc.), 1954. Pathological changes in rats from feeding of various flavoring agents. Private communication to FEMA. Unpublished report from Food and Drug Administration, 05 October. Report No. 4850. RIFM, Woodcliff Lake, NJ, USA.
29. RIFM (Research Institute for Fragrance Materials Inc.), 1972a. Acute toxicity studies in rats and in rabbits. RIFM Report No. 2711, April 07. RIFM, Woodcliff Lake, NJ, USA.
30. RIFM (Research Institute for Fragrance Materials Inc.), 1972b. The contact-sensitization potential of fragrance materials by maximization testing in humans. RIFM Report No. 1804, June 1. RIFM, Woodcliff Lake, NJ, USA.
31. RIFM (Research Institute for Fragrance Materials Inc.), 1974. In vitro study on the hydrolysis of twenty-six organic esters by pancreatin. Private communication from IOFI, 12 February. RIFM Report No. 8216. RIFM, Woodcliff Lake, NJ, USA.
32. RIFM (Research Institute for Fragrance Materials Inc.), 1975. Report on human maximization studies. RIFM Report No. 1799, March 27. RIFM, Woodcliff Lake, NJ, USA.
33. RIFM (Research Institute for Fragrance Materials Inc.), 2005a. Repeated insult patch test with benzyl cinnamate. RIFM Report No. 49109, June 23. RIFM, Woodcliff Lake, NJ, USA.
34. RIFM (Research Institute for Fragrance Materials Inc.), 2005b. Local Lymph Node Assay. RIFM Report No. 48751, January 26. RIFM, Woodcliff Lake, NJ, USA.
35. Yoo Y.S. Mutagenic and antimutagenic activities of flavoring agents used in foodstuffs. J. Osaka Shiritso Daigaku Igaku Zasshi 34 (1986) 267-288