KIT and PDGFRα mutational analyses of mixed cell-type gastrointestinal stromal tumours

Histopathology

Volumn 51, Issue 6, 2007, Pages 758-762

  Wong, N A C S ^a   Mangwana, S ^a  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Gastrointestinal stromal tumour; Genetic mutation; KIT; Mixed cell type; PDGFR

Indexed keywords

CD34 ANTIGEN; IMATINIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; PRIMER DNA;

ADULT; AGED; ARTICLE; CELL TYPE; CONTROLLED STUDY; DNA EXTRACTION; EPITHELIOID CELL; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENE DELETION; GENE INSERTION; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERSTITIAL CELL OF CAJAL; MALE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION; SPINDLE CELL; GENETICS; LASER; MICRODISSECTION; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY;

AGED; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; FEMALE; GASTROINTESTINAL STROMAL TUMORS; HUMANS; IMMUNOHISTOCHEMISTRY; LASERS; MALE; MICRODISSECTION; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA;

EID: 36549050729     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2007.02866.x     Document Type: Article

References (15)

1. DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann. Surg. 2000 231 51 58.
2. Demetri GD, von Mehren M, Blanke CD et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. 2002 347 472 480.
3. Heinrich MC, Corless CL, Demetri GD et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J. Clin. Oncol. 2003 21 4342 4349.
4. Fletcher CD, Berman JJ, Corless C et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum. Pathol. 2002 33 459 465.
5. Penzel R, Aulmann S, Moock M, Schwarzbach M, Rieker RJ, Mechtersheimer G. The location of KIT and PDGFRA gene mutations in gastrointestinal stromal tumours is site and phenotype associated. J. Clin. Pathol. 2005 58 634 639.
6. Orosz Z, Tornoczky T, Sapi Z. Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases. Pathol. Oncol. Res. 2005 11 11 21.
7. Liu FY, Qi JP, Xu FL, Wu AP. Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor. World J. Gastroenterol. 2006 12 4161 4165.
8. Pauls K, Merkelbach-Bruse S, Thal D, Buttner R, Wardelmann E. PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features. Histopathology 2005 46 166 175.
9. Tornillo L, Terracciano LM. An update on molecular genetics of gastrointestinal stromal tumours. J. Clin. Pathol. 2006 59 557 563.
10. Lasota J, Dansonka-Mieszkowska A, Sobin LH, Miettinen M. A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential. Lab. Invest. 2004 84 874 883.
11. Wong NA, Young R, Malcomson RD et al. Prognostic indicators for gastrointestinal stromal tumours: a clinicopathological and immunohistochemical study of 108 resected cases of the stomach. Histopathology 2003 43 118 126.
12. Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am. J. Surg. Pathol. 2005 29 52 68.
13. Agaimy A, Wunsch PH, Hofstaedter F et al. Minute gastric sclerosing stromal tumors (GIST Tumorlets) are common in adults and frequently show c-KIT mutations. Am. J. Surg. Pathol. 2007 31 113 120.
14. Sommer G, Agosti V, Ehlers I et al. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor kinase. Proc. Natl Acad. Sci. U.S.A. 2003 100 6706 6711.
15. Kawanowa K, Sakuma Y, Sakurai S et al. High incidence of microscopic gastrointestinal stromal tumors in the stomach. Hum. Pathol. 2006 37 1527 1535.