Update on actinic keratosis in clinical trial experience with imiquimod

British Journal of Dermatology

Volumn 157, Issue SUPPL. 2, 2007, Pages 32-33

  Ferrandiz C ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Actinic keratosis; Imiquimod

Indexed keywords

CYTOKINE; IMIQUIMOD; PLACEBO; TOLL LIKE RECEPTOR 7;

ACTINIC KERATOSIS; AGONIST; CARCINOMA IN SITU; CELLULAR IMMUNITY; CLINICAL TRIAL; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; EUROPE; HUMAN; LOCAL SKIN REACTION; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; PRURITUS; REVIEW; SKIN BURNING SENSATION; SKIN CANCER; SKIN ULCER; SQUAMOUS CELL CARCINOMA; UNITED STATES;

AMINOQUINOLINES; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; HUMANS; KERATOSIS; NEOPLASMS, RADIATION-INDUCED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SKIN NEOPLASMS; TREATMENT OUTCOME; ULTRAVIOLET RAYS;

EID: 36549034197     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2007.08270.x     Document Type: Review

References (9)

1. Dodson JM, DeSpain J, Hewett JE, Clark DP. Malignant potential of actinic keratoses and the controversy over treatment. A patient-oriented perspective. Arch Dermatol 1991 127:1029 31.
2. Cockerell CJ. Histopathology of incipient intraepidermal squamous cell carcinoma (actinic keratosis). J Am Acad Dermatol 2000 42:11 17.
3. Stockfleth E, Meyer T, Benninghoff B et al. A randomised, double blind, vehicle-controlled study to asses 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol 2002 138:1498 502.
4. Lebwohl M, Dinehart S, Whiting D et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomised, double blind, parallel group, vehicle controlled trials. J Am Acad Dermatol 2004 50:714 21.
5. Szeimies RM, Gerritsen MJ, Gupta G et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double blind, vehicle-controlled clinical trial with histology. J Am Acad Dermatol 2004 51:547 55.
6. Korman N, Moy R, Ling M et al. Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis: results of two phase 3, randomized, double blind, parallel group, vehicle-controlled trials. Arch Dermatol 2005 41:467 73.
7. Alomar A, Bichel J, McRae S. Vehicle-controlled, randomized, double-blind study to assess safety and efficacy of Imiquimod 5% cream applied once daily 3 days per week in one or two courses of treatment of actinic keratoses on the head. Br J Dermatol 2007 157:133 41.
8. Jorizzo J, Dinehart S, Matheson R et al. Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head. J Am Acad Dermatol. 2007 57:265 8.
9. Falagas ME, Angelousi AG, Peppas G. Imiquimod for the treatment of actinic keratosis: a meta-analysis of randomised controlled trials. J Am Acad Dermatol 2006 55:537 8.