Lipopolysaccharide-induced cerebral inflammatory damage and the therapeutic effect of platelet activating factor receptor antoganist

Neuroscience Bulletin

Volumn 23, Issue 5, 2007, Pages 271-276

  Liu, Wen Chao ^a   Ding, Wen Long ^a   Gu, Hong Yu ^a   Chen, Ming Feng ^a   Hu, Jin Jia ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Brain inflammation; Ginkgolide B; Microglia; Platelet activating factor; Ultrastructure

Indexed keywords

GINKGOLIDE B; LIPOPOLYSACCHARIDE; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN NERVE CELL; BRAIN PROTECTION; BRAIN VENTRICLE; CELL DENSITY; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFECT; ENCEPHALITIS; EXPERIMENTAL MODEL; IMMUNOHISTOCHEMISTRY; LEARNING; MAZE TEST; MEMORY; MICROGLIA; NONHUMAN; POLYSOME; RAT; ROUGH ENDOPLASMIC RETICULUM; SPRAGUE DAWLEY RAT; SWIMMING; SYNAPSE; TASK PERFORMANCE; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT OUTCOME;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN DISEASES; FIBRINOLYTIC AGENTS; GINKGOLIDES; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LACTONES; LIPOPOLYSACCHARIDES; MAZE LEARNING; MICROGLIA; MICROSCOPY, ELECTRON, TRANSMISSION; NEURONS; PLATELET ACTIVATING FACTOR; PLATELET MEMBRANE GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED;

EID: 36549032781     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-007-0040-z     Document Type: Article

References (13)

1. Pavlik VN, Doody RS, Massman, Chan W. Influence of premorbid IQ and education on progression of Alzheimer's disease. Dement Geriatr Cogn Disord 2006, 22: 367-377.
2. Walker DG, Link J, Lue LF, Dalsing-Hernandez JE, Boyes BE. Gene expression changes by amyloid β peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. J Leukoc Biol 2006, 79: 596-610.
3. Gasparini L, Ongini E, Wilcock, Morgan D. Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain Res Brain Res Rev 2005, 48: 400-408.
4. Hershkowitz M, Adunsky A. Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. Neurobiol Aging 1996, 17: 865-868.
5. Pang Y, Cai Z, Rhodes PG. Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide. Brain Res Dev Brain Res 2003, 140: 205-214.
6. Zink WE, Anderson E, Boyle J, Hock L, Rodriguez-Sierra J, Xiong H, et al. Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis. J Neurosci 2002, 22: 2096-2105.
7. Xu J, Qian CY. Excitotoxic neurodegeneration in Alzheimer disease. Chin J Neurosci 2000, 16: 379-382.
8. Hauss-Wegrzyniak B, Vannucchi MG, Wenk GL. Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats. Brain Res 2000, 859: 157-166.
9. Liu Y, Walter S, Stagi M, Cherny D, Letiembre M, Schulz-Schaeffer W, et al. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain 2005, 128 (Pt 8): 1778-1789.
10. Hauss-Wegrzyniak B, Lukovic L, Bigaud M, Stoeckel ME. Brain inflammatory response induced by intracerebroventricular infusion of lipopolysaccharide: an immunohistochemical study. Brain Res 1998, 794: 211-224.
11. Leutgeb A, Mizumori SJ. Excitotoxic septal lesions result in spatial memory deficits and altered flexibility of hippocampal single-unit representations. J Neurosci 1999, 19: 6661-6672.
12. Kondratskaya EL, Pankratov YV, Lalo UV, Chatterjee SS, Krishtal OA. Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. Neurochem Int 2004, 44: 171-177.
13. Xu Y, Tao YX. Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. Neuroreport 2004, 15: 263-266.