Calorie restriction, post-reproductive life span, and programmed aging: A plea for rigor

Annals of the New York Academy of Sciences

Volumn 1119, Issue 1, 2007, Pages 296-305

  De Grey, Aubrey D N J ^a,b  

^a Methuselah Foundation   (United Kingdom)

^b NONE   (United States)

Author keywords

Calorie restriction; Post reproductive life span; Programmed aging; Rigor

Indexed keywords

AGING; CALORIC RESTRICTION; CONFERENCE PAPER; EVOLUTION; GENETICS; GERONTOLOGY; HUMAN; LIFESPAN; RIGOR; SCIENTIST; SENESCENCE; UNCERTAINTY;

EID: 36549017642     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1404.029     Document Type: Conference Paper

References (18)

1. MEDAWAR, P.B. 1952. An Unsolved Problem in Biology. H.K. Lewis. London.
2. HALDANE, J.B.S. 1942. New Paths in Genetics. Harper. London.
3. WEISMANN, A. 1891. Essays upon Heredity and Kindred Biological Problems, 2nd ed., Vol. 1. Clarendon Press. Oxford.
4. WILLIAMS, G.C. 1957. Pleiotropy, natural selection and the evolution of senescence. Evolution 11: 398-411.
5. HAMILTON, W.D. 1966. The moulding of senescence by natural selection. J. Theor. Biol. 12: 12-45.
6. KIRKWOOD, T.B.L & R. HOLLIDAY. 1979. The evolution of ageing and longevity. Proc. R. Soc. Lond. B Biol. Sci. 205: 531-546.
7. GOLDSMITH, T.C. 2004. Aging as an evolved characteristic - Weismann's theory reconsidered. Med. Hypotheses 62: 304-308.
8. MITTELDORF, J. 2006. Howevolutionary thinking affects people's ideas about aging interventions. Rejuvenation Res. 9: 346-350.
9. BOWLES, J.T. 1998. The evolution of aging: a new approach to an old problem of biology. Med. Hypotheses 51: 179-221.
10. LIBERTINI, G. 2006. Evolutionary explanations of the "actuarial senescence in the wild" and of the "state of senility". Scientific World Journal 6: 1086-1108.
11. FINCH, C.E. 1990. Longevity, Senescence and the Genome. University of Chicago Press. Chicago.
12. DE GREY, A.D.N.J. 2005. The unfortunate influence of the weather on the rate of aging. Gerontology 51: 73-82.
13. FRIEDMAN, D.B. & T.E. JOHNSON. 1988. Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J. Gerontol. 43: B102-B109.
14. KENYON, C., J. CHANG, E. GENSCH, et al. 1993. A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
15. DE GREY, A.D.N.J. 2005. Resistance to debate on how to postpone ageing is delaying progress and costing lives. EMBO Rep. 6(S1): S49-S53.
16. DE GREY, A.D.N.J. 2006. Compression of morbidity: the hype and the reality, part 1. Rejuvenation Res. 9: 1-2.
17. DE GREY, A.D.N.J. 2006. Compression of morbidity: the hype and the reality, part 2. Rejuvenation Res. 9: 167-168.
18. DE GREY, A.D.N.J. 2006. Has Hippocrates had his day? Rejuvenation Res. 9: 371-373.