Immunogenetic factors in donors and patients that affect the outcome of hematopoietic stem cell transplantation

Blood Cells, Molecules, and Diseases

Volumn 40, Issue 1, 2008, Pages 40-43

  Madrigal, Alejandro ^a,b   Shaw, Bronwen E ^a,b  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

DPB1; Hematopoietic stem cell transplantation; HLA; NOD2 CARD15; Tregs

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; HLA A ANTIGEN; HLA ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DP ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ALLELE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CHRONIC MYELOID LEUKEMIA; DISEASE FREE SURVIVAL; DONOR; FOLLOW UP; GENOTYPE; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; HUMAN; IMMUNOGENETICS; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RELAPSE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; SURVIVAL TIME; TREATMENT OUTCOME;

EID: 36549001173     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2007.08.004     Document Type: Article

References (18)

1. Shaw B.E., Madrigal J.A., and Potter M. Improving the outcome of unrelated donor stem cell transplantation by molecular matching. Blood Rev. 15 (2001) 167-174
2. Petersdorf E.W., Anasetti C., Martin P.J., and Hansen J.A. Tissue typing in support of unrelated hematopoietic cell transplantation. Tissue Antigens 61 (2003) 1-11
3. Morishima Y., Sasazuki T., Inoko H., Juji T., Akaza T., Yamamoto K., Ishikawa Y., Kato S., Sao H., Sakamaki H., Kawa K., Hamajima N., Asano S., and Kodera Y. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood 99 (2002) 4200-4206
4. Flomenberg N., Baxter-Lowe L.A., Confer D., Fernandez-Vina M., Filipovich A., Horowitz M., Hurley C., Kollman C., Anasetti C., Noreen H., Begovich A., Hildebrand W., Petersdorf E., Schmeckpeper B., Setterholm M., Trachtenberg E., Williams T., Yunis E., and Weisdorf D. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 104 (2004) 1923-1930
5. Sasazuki T., Juji T., Morishima Y., Kinukawa N., Kashiwabara H., Inoko H., Yoshida T., Kimura A., Akaza T., Kamikawaji N., Kodera Y., and Takaku F. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N. Engl. J. Med. 339 (1998) 1177-1185
6. Petersdorf E., Gooley W., Malkki M., et al. The biological significance of HLA-DP gene variation in haematopoietic cell transplantation. Br. J. Haematol. 112 (2001) 988-994
7. Cohen J.L., Trenado A., Vasey D., et al. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196 (2002) 401-406
8. Davies J.D., Leong L.Y., Mellor A., et al. T cell suppression in transplantation tolerance through linked recognition. J. Immunol. 156 (1996) 3602-3607
9. Hara M., Kingsley C.I., Niimi M., et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166 (2001) 3789-3796
10. Hoffmann P., Ermann J., Edinger M., et al. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196 (2002) 389-399
11. Jiang S., Camara N., Lombardi G., and Lechler R.I. Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. Blood 102 (2003) 2180-2186
12. Kingsley C.I., Karim M., Bushell A.R., and Wood K.J. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168 (2002) 1080-1086
13. Taylor P.A., Lees C.J., and Blazar B.R. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99 (2002) 3493-3499
14. Wood K.J., and Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat. Rev., Immunol. 3 (2003) 199-210
15. Holler E., et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104 (2004) 889-894
16. Holler E., et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 107 (2006) 4189-4193
17. Elmaagacli A.H., et al. Mutations in Innate Immune System NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft versus host disease in patients who underwent an allogeneic transplantation. Transplantation 81 (2006) 247-254
18. Granell M., et al. Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation. Haematologica 91 (2006) 1372-1376