Pediatric septic shock treatment: New clues from genomic profiling

Pharmacogenomics

Volumn 8, Issue 10, 2007, Pages 1287-1290

  Wong, Hector R ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BINDING PROTEIN; T LYMPHOCYTE RECEPTOR; ZINC; ZINC FINGER PROTEIN;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; APOPTOSIS; BIOCHEMISTRY; CHILD; CHILD HEALTH CARE; CHILDHOOD MORTALITY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE COURSE; DOWN REGULATION; EDITORIAL; FINANCIAL MANAGEMENT; GENE EXPRESSION PROFILING; GENE REPRESSION; GENETIC ANALYSIS; GENETIC DATABASE; GENETIC LINKAGE; HIGH THROUGHPUT SCREENING; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INFORMATION PROCESSING; INNATE IMMUNITY; INTENSIVE CARE; LYMPHOCYTE FUNCTION; MALNUTRITION; MEDICAL RESEARCH; MICROARRAY ANALYSIS; NATURAL KILLER CELL; PUBLIC HEALTH PROBLEM; RELIABILITY; SEPTIC SHOCK; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UNITED STATES; ZINC DEFICIENCY;

CHILD; COHORT STUDIES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME, HUMAN; HUMANS; SHOCK, SEPTIC;

EID: 36448989706     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.8.10.1287     Document Type: Editorial

References (35)

1. Hazelzet JA, Driessen GJA, Abboud P, Wheeler DS, Shanley TP, Wong HR: Sepsis. In: Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. Wheeler DS, Wong HR, Shanley TP (Eds). Springer, Berlin, Germany, 1421-1444 (2007).
2. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC: The epidemiology of severe sepsis in children in the United States. Am. J. Respir. Crit. Care Med. 167, 695-701 (2003).
3. Watson RS, Carcillo JA: Scope and epidemiology of pediatric sepsis. Pediatr. Crit. Care Med. 6, S3-5 (2005).
4. Carcillo JA, Fields AI: Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic Shock. Crit. Care Med. 30, 1365-1378 (2002).
5. Nadel S, Goldstein B, Williams MD et al.: Drotrecogin α (activated) in children with severe sepsis: a multicentre Phase III randomised controlled trial. Lancet 369, 836-843 (2007).
6. Laudanski K, Miller-Graziano C, Xiao W et al.: Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad. Sci. USA 103, 15564-15569 (2006).
7. Calvano SE, Xiao W, Richards DR et al.: A network-based analysis of systemic inflammation in humans. Nature 437, 1032-1037 (2005).
8. Cobb JP, Mindrinos MN, Miller-Graziano C et al.: Application of genomewide expression analysis to human health and disease. Proc. Natl Acad. Sci. USA 102, 4801-4806 (2005).
9. Pachot A, Lepape A, Vey S, Bienvenu J. Mougin B, Monneret G: Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study. Immunol. Lett. 106, 63-71 (2006).
10. Prucha M, Ruryk A, Boriss H et al.: Expression profiling: toward an application in sepsis diagnostics. Shock. 22, 29-33 (2004).
11. Wong HR, Shanley TP, Sakthivel B et al.: Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol. Genomics 30, 146-155 (2007).
12. King JC, Shames DM, Woodhouse LR: Zinc homeostasis in humans. J. Nutr. 130, 1360S-1366S (2000).
13. Gaetke LM, McClain CJ, Talwalkar RT, Shedlofsky SI: Effects of endotoxin on zinc metabolism in human volunteers. Am. J. Physiol. 272, E952-956 (1997).
14. Failla ML: Trace elements and host defense: recent advances and continuing challenges. J Nutr. 133, 1443S-1447S (2003).
15. Fraker PJ, King LE: Reprogramming of the immune system during zinc deficiency. Annu. Rev. Nutr. 24, 277-298 (2004).
16. Ibs KH, Rink L: Zinc-altered immune function. J Nutr. 133, 1452S-1456S (2003).
17. Rink L, Haase H: Zinc homeostasis and immunity. Trends Immunol. 28, 1-4 (2007).
18. Shanley TP, Cvijanovich N, Lin R et al.: Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic Shock. Mol. Med. (2007) [Epub ahead of print].
19. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348, 138-150 (2003).
20. Abraham E: Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med. 25, 556-566 (1999).
21. Ayala A, Chaudry IH: Immune dysfunction in murine polymicrobial sepsis: mediators, macrophages, lymphocytes and apoptosis. Shock 6(Suppl.1), S27-S38 (1996).
22. Hotchkiss RS, Tinsley KW, Karl IE: Role of apoptotic cell death in sepsis. Scand J. Infect. Dis. 35, 585-592 (2003).
23. Hotchkiss RS, Coopersmith CM, Karl IE: Prevention of lymphocyte apoptosis - a potential treatment of sepsis? Clin. Infect. Dis. 41(Suppl.7), S465-S469 (2005).
24. Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE: Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J. Immunol. 174, 5110-5118 (2005).
25. Hotchkiss RS, McConnell KW, Bullok K et al.: TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J. Immunol. 176, 5471-5477 (2006).
26. Chang KC, Unsinger J, Davis CG et al.: Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. Faseb J. 21, 708-719 (2007).
27. Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A: Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects an macrophage apoptotic and functional capacity. J. Leukoc. Biol. 74, 344-351 (2003).
28. Hotchkiss RS, Swanson PE, Knudson CM et al.: Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J. Immunol. 162, 4148-4156 (1999).
29. Mahidhara R, Billiar TR: Apoptosis in sepsis. Crit. Care Med. 28, N105-113 (2000).
30. Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A: Leukocyte apoptosis and its significance in sepsis and shock. J. Leukoc. Biol. 78, 325-337 (2005).
31. Hotchkiss RS, Swanson PE, Freeman BD et al.: Apoptotic cell death in patients with sepsis, Shock, and multiple organ dysfunction. Crit. Care Med. 27, 1230-1251 (1999).
32. Felmet KA, Hall MW, Clark RS, Jaffe R, Carcillo JA: Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J. Immunol. 174, 3765-3772 (2005).
33. Heidecke CD, Hensler T, Weighardt H et al.: Selective defects of T lymphocyte function in patients with lethal intraabdominal infection. Am. J. Surg. 178, 288-292 (1999).
34. King LE, Osati-Ashtiani F, Fraker PJ: Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. J. Nutr. 132, 974-979 (2002).
35. Kitamura H, Morikawa H, Kamon H et al.: Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat. Immunol. 7, 971-977 (2006).