Detailed structure of integrons and transposons carried by large conjugative plasmids responsible for multidrug resistance in diverse genomic types of Salmonella enterica serovar Brandenburg

Journal of Antimicrobial Chemotherapy

Volumn 60, Issue 6, 2007, Pages 1227-1234

  Martínez, Noelia ^a   Mendoza, Carmen M ^a   Rodríguez, Irene ^a   Soto, Sara ^a   Bances, Margarita ^b   Rodicio, M Rosario ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b Laboratorio de Salud Publica   (Spain)

Author keywords

1600 bp dfrA1 aadA1 integrons; Conjugative plasmids; PFGE; RAPD; Transposons

Indexed keywords

AMPICILLIN; CHLORAMPHENICOL; CIPROFLOXACIN; COTRIMOXAZOLE; GENTAMICIN; KANAMYCIN; NALIDIXIC ACID; STREPTOMYCIN; SULFADIAZINE; TETRACYCLINE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIUM CONJUGATION; BACTERIUM ISOLATE; CONTROLLED STUDY; DNA SEQUENCE; GENE CASSETTE; GENE IDENTIFICATION; GENE LOCATION; GENE STRUCTURE; INCIDENCE; INTEGRON; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; RANDOM AMPLIFIED POLYMORPHIC DNA; SALMONELLA ENTERICA; SALMONELLOSIS; SEROTYPE; SPAIN; TRANSPOSON;

ANTI-BACTERIAL AGENTS; CLONING, MOLECULAR; CONJUGATION, GENETIC; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; INTEGRONS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERASE CHAIN REACTION; RANDOM AMPLIFIED POLYMORPHIC DNA TECHNIQUE; SALMONELLA ENTERICA; SALMONELLA INFECTIONS; SEQUENCE ANALYSIS, DNA; SEROTYPING;

EID: 36448972711     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm336     Document Type: Article

References (39)

1. Guerra B, Soto S, Cal S et al. Antimicrobial resistance and spread of class 1 integrons among Salmonella serotypes. Antimicrob Agents Chemother 2000; 44: 2166-9.
2. Soto SM, Guerra B, del Cerro A et al. Outbreaks and sporadic cases of Salmonella serovar Panama studied by DNA fingerprinting and antimicrobial resistance. Int J Food Microbiol 2001; 71: 35-43.
3. Soto SM, Martín MC, Mendoza MC. Distinctive human and swine strains of Salmonella enterica serotype Wien carry large self-transferable R-plasmids. A plasmid contains a class 1-qacEΔ1-sul1 integron with the dfrA1-aadA1a cassette configuration. Food Microbiol 2003; 20: 9-16.
4. Guerra B, Junker E, Miko A et al. Characterization and localization of drug resistance determinants in multidrug-resistant, integron-carrying Salmonella enterica serotype Typhimurium strains. Microb Drug Resist 2004; 10: 83-91.
5. Martínez N, Mendoza MC, Guerra B et al. Genetic basis of antimicrobial drug resistance in clinical isolates of Salmonella enterica serotype Hadar from a Spanish region. Microb Drug Resist 2005; 11: 185-93.
6. Rodríguez I, Rodicio MR, Mendoza MC et al. Large conjugative plasmids from clinical strains of Salmonella enterica serovar Virchow contain a class 2 integron in addition to class 1 integrons and several non-integron-associated drug resistance determinants. Antimicrob Agents Chemother 2006; 50: 1603-7.
7. Rodríguez I, Martin MC, Mendoza MC et al. Class 1 and class 2 integrons in non-prevalent serovars of Salmonella enterica: structure and association with transposons and plasmids. J Antimicrob Chemother 2006; 58: 1124-32.
8. Herrero A, Rodicio MR, González-Hevia MA et al. Molecular epidemiology of emergent multidrug-resistant Salmonella enterica serotype Typhimurium strains carrying the virulence resistance plasmid pUO-StVR2. J Antimicrob Chemother 2006; 57: 39-45.
9. Rodríguez M, de Diego I, Mendoza MC. Extraintestinal salmonellosis in a general hospital. J Clin Microbiol 1991; 36: 3291-6.
10. Threlfall EJ, Fisher IST, Berghold C et al. Antimicrobial drug resistance in isolates of Salmonella enterica from cases of salmonellosis in humans in Europe in 2000: Results of international multi-centre surveillance. Euro Surveill 2003; 8: 41-5.
11. Baquar N, Burnens A, Stanley J. Comparative evaluation of molecular typing of strains from a national epidemic due to Salmonella brandenburg by rRNA gene and IS200 probes and pulse field gel electrophoresis. J Clin Microbiol 1994; 32:1876-80.
12. Wright JM, Brett M, Bennett J. Laboratory investigation and comparison of Salmonella Brandenburg cases in New Zealand. Epidemiol Infect 1998; 121: 49-55.
13. Wybot I, Wildemauwe C, Godard C et al. Antimicrobial drug resistance in nontyphoid human Salmonella in Belgium: Trends for the period 2000-2002. Acta Clin Belg 2004; 59: 152-60.
14. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Susceptibility Testing-Fifteenth Informational Supplement: Approved Standard M100-S15. NCCLS, Wayne, PA, USA, 2005.
15. Guerra B, Junker E, Helmuth R. Incidence of recently described sulfonamide resistance gene su/3 among German Salmonella enterica strains isolated from livestock and food. Antimicrob Agents Chemother 2004; 48: 2712-5.
16. White PA, McIver CJ, Rawlinson WD. Integrons and gene cassettes in the Enterobacteriaceae. Antimicrob Agents Chemother 2001; 45: 2658-61.
17. Heffron F, McCarthy BJ, Ohtsubo H et al. DNA sequence of the transposon Tn3: Three genes and three sites involved in transposition of Tn3. Cell 1979; 18: 1153-63.
18. Liebert CA, Hall RM, Summers AO. Transposon Tn21, flagship of the floating genome. Microbiol Mol Biol Rev 1999; 63: 507-22.
19. Allmeier H, Cresnar B, Greck M et al. Complete nucleotide sequence of Tn1721-gene organization and a novel gene-product with features of chemotaxis protein. Gene 1992; 111: 11-20.
20. Coleman DC, Chopra I, Shales SW et al. Analysis of tetracycline resistance encoded by transposon Tn10: Deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes. J Bacteriol 1983; 153: 921-9.
21. Schnabel EL, Jones AL. Distribution of tetracycline resistance genes and transposons among phylloplane bacteria in Michigan apple orchards. Appl Environ Microbiol 1999; 65: 4898-907.
22. Ng LK, Martin I, Alfa M et al. Multiplex PCR for detection of etracycline resistant genes. Mol Cell Probes 2001; 15: 209-15.
23. Pezella C, Ricci A, DiGiannatale E et al. Tetracycline and streptomycin resistance genes, transposons, and plasmids in Salmonella enterica isolates from animals in Italy. Antimicrob Agents Chemother 2004; 48: 903-8.
24. Morsczeck C, Langendörfer D, Schierholz JM. A quantitative real-time PCR assay for the detection of tetR of Tn10 in Escherichia coli using SYBR green and the opticon. J Biochem Biophys Methods 2004; 59: 217-27.
25. Sambrook J, Russel DW. Molecular Cloning: A Laboratory Manual, third edition. New York: Cold Spring Harbor Laboratory, 2001.
26. Altschul SF, Madden TL, Schaffer AA et al. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 1997; 25: 3389-402.
27. Chen S, Cui S, McDermott PF et al. Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar Typhimurium to fluoroquinolones and other antimicrobials. Antimicrob Agents Chemother 2007; 51: 535-42.
28. Schlüter A, Heuer H, Szczepanowski R et al. The 64,508 bp IncP-1β antibiotic multiresistance plasmid pB10 isolated from a waste-water treatment plant provides evidence for recombination between members of different branches of the IncP-1 β group. Microbiology 2003; 149: 3139-53.
29. Chong P, Hui I, Loo T et al Structural analysis of a new GC-specific insertion element IS186. FEBS Lett 1985; 192: 47-52.
30. Griffith KL, Becker SM, Wolf RE, Jr. Characterization of TetD as a transcriptional activator of a subset of genes of Escherichia coli SoxS/MarA/Rob regulon. Mol Microbiol 2005; 56: 1103-17.
31. Zhao S, Qaiyumi S, Friedman S et al. Characterization of Salmonella enterica serotype Newport isolated from humans and food animals. J Clin Microbiol 2003; 41: 5366-71.
32. Daly M, Buckley J, Power E et al. Evidence for a chromosomally-located third integron in Salmonella Typhimurium DT104b. Antimicrob Agents Chemolher 2004; 48: 1350-2.
33. Nógrády N, Gadó I, Tóth Á et al. Antibiotic resistance and class 1 integron patterns of non-typhoidal human Salmonella serotypes isolated in Hungary in 2002 and 2003. Int J Antimicrob Agents 2005; 26: 126-32.
34. Miko A, Pries K, Schroeter A et al. Molecular mechanisms of resistance in multidrug-resistant serovars of Salmonella enterica isolated from foods in Germany. J Antimicrob Chemother 2005; 56 1025-33.
35. Antunes P, Machado J, Sousa JC et al. Dissemination of sulfonamide resistance genes (suit1, sul2 and sul3) in Portuguese Salmonella enterica strains and relation with integrons. Antimicrob Agents Chemother 2005; 49: 836-9.
36. Frech G, Schwarz S. Plasmid-encoded tetracycline resistance in Salmonella enterica subsp. enterica serovars choleraesuis and typhimurium: Identification of complete and truncated Tn 1721 elements. FEMS Microbiol Left 1999; 176: 97-103.
37. Pasquali F, Kehrenberg C, Manfreda G et al. Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium. J Antimicrob Chemother 2005; 55: 562-5.
38. Chen C-Y, Nace GW, Solow B et al. Complete nucleotilde sequences of 84.5- and 3.2-kb plasmids in the multi-antibiotic resistant Salmonella enterica serovar Typhimurium U302 strain G8430. Plasmid 2007; 57: 29-43.
39. Echeita A, Aladueña A, González-Sanz R et al. Análisis de las cepas de Salmonella spp aisladas de muestras clínicas de origen humano en España: Ahos 2002 y 2003 (1). Boletín Epidemiológico Semanal 2005; 13: 73-6.