The cumulative and sublethal effects of turbulence on erythrocytes in a stirred-tank model

Annals of Biomedical Engineering

Volumn 35, Issue 12, 2007, Pages 2108-2120

  Aziz, Abdulhameed ^a,b   Werner, Brian C ^a   Epting, Kevin L ^a   Agosti, Christopher D ^c   Curtis, Wayne R ^a  

^a The Pennsylvania State University   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c University of Pittsburgh   (United States)

Author keywords

Blood; Cardiac; Cardiovascular; Eddy; Hemolysis; Kolmogorov; Laminar; Prosthetic; Red blood cell; Valve; Vascular

Indexed keywords

CELL DAMAGE; ERYTHROCYTES; LOGISTIC MODELS; OSMOTIC FRAGILITY (OF);

BLOOD; OSMOSIS; PARAMETER ESTIMATION; SHEAR STRESS; TURBULENT FLOW; WAVELENGTH;

CELLS;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BLOOD PRESSURE; CELL CULTURE; CELL SURVIVAL; COMPUTER SIMULATION; CULTURE TECHNIQUE; CYTOLOGY; ERYTHROCYTE; HEMOLYSIS; INSTRUMENTATION; METHODOLOGY; NONLINEAR SYSTEM; PHYSIOLOGY; SHEAR STRENGTH; SWINE;

ANIMALS; BLOOD PRESSURE; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; COMPUTER SIMULATION; ERYTHROCYTES; HEMOLYSIS; MODELS, CARDIOVASCULAR; NONLINEAR DYNAMICS; SHEAR STRENGTH; SWINE;

EID: 36448953486     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-007-9387-6     Document Type: Article

References (43)

1. Agar, N. S., and P. G. Board. Red Blood Cells of Domestic Mammals. New York, New York: Elsevier Science Publications, 420 pp., 1983.
2. Aziz, A. Sub-lethal Effects of Turbulence on Red Blood Cells. University Park, Pennsylvania: The Pennsylvania State University, 73 pp., 2000.
3. Bludszuweit C. (1995) Model for a general mechanical blood damage prediction. Artif. Organs 19:583-589
4. Bludszuweit C. (1995) Three-dimensional numerical prediction of stress loading of blood particles in a centrifugal pump. Artif. Organs 19:590-596
5. Bluestein M., Mockros L.F. (1969) Hemolytic effects of energy dissipation in flowing blood. Med Biol Eng 7:1-16
6. Chasis J.A., Mohandas N. (1986) Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations. J. Cell. Biol. 103:343-350
7. Cristini V., Blawzdziewicz J., Loewenberg M. (1998) Drop breakup in three-dimensional viscous flows. Phys. Fluids 10:1781-1783
8. Cristini V., Blawzdziewicz J., Loewenberg M., Collins L.R. (2003) Breakup in stochastic flows: sub-Kolmogorov drops in isotropic turbulence. J. Fluid Mech. 492:231-250
9. Croughan M.S., Sayre E.S., Wang D.I. (1989) Viscous reduction of turbulent damage in animal cell culture. Biotechnol. Bioeng. 33:863-870
10. Curtis W.R., Emery A.H. (1993) Plant cell suspension culture rheology. Biotechnology and Bioengineering 42:520-526
11. Dacie, J. V., and S. M. Lewis. Practical Haematology. Edinburgh, New York: Churchill Livingstone, 609 pp., 1995.
12. Evans E.A., Hochmuth R.M. (1976) Membrane viscoplastic flow. Biophys. J. 16:13-26
13. Fernandez J., Laub G.W., Adkins M.S., Anderson W.A., Chen C., Bailey B.M., Nealson L., McGrath L. (1994) Early and late-phase events after valve replacement with the St. Jude Medical Prosthesis in 1200 patients. J. Thorac. Cardiovasc. Surg. 107:394-407
14. Fischer T.M., Stohr-Lissen M., Schmid-Schonbein H. (1978) The red cell as a fluid droplet: tank tread-like motion of the human erythrocyte membrane in shear flow. Science 202:894-896
15. Garrison, L. A. Hemolytic Effects of Chemical Additives, Aortic Pressure Changes, and Cavitation in Two New Mock Circulatory Loops Driven by the Penn State Ventricular Assist Device. University Park, Pennsylvania: The Pennsylvania State University, 146 pp., 1994.
16. Grigioni M., Daniele C., D'Avenio G., Barbaro V. (2001) The influence of the leaflet's curvature on the flow field in two bileaflet prosthetic heart valves. J. Biomech. 34:613-621
17. Hsiao, A. Continuous Flow Reactor Design For the Study of Red Blood Cell Disruption. University Park, Pennsylvania: The Pennsylvania State University, 39 pp., 1999.
18. Jones S.A. (1995) A relationship between Reynolds stresses and viscous dissipation: implications to red cell damage. Ann. Biomed. Eng. 23:21-28
19. Kameneva M.V., Burgreen G.W., Kono K., Repko B., Antaki J.F., Umezu M. (2004) Effects of turbulent stresses upon mechanical hemolysis: experimental and computational analysis. Asaio J. 50:418-423
20. Kameneva M.V., Undar A., Antaki J.F., Watach M.J., Calhoon J.H., Borovetz H.S. (1999) Decrease in red blood cell deformability caused by hypothermia, hemodilution, and mechanical stress: factors related to cardiopulmonary bypass. Asaio J. 45:307-310
21. Lamson, T. C. Relative Blood Damage in the Three Phases of a Prosthetic Heart Valve Flow Cycle. University Park, Pennsylvania: The Pennsylvania State University, 150 pp., 1993.
22. Leister, S. E. Disruption of Red Blood Cells due to Turbulence. University Park, Pennsylvania: The Pennsylvania State University, 62 pp., 2000.
23. Liu J.S., Lu P.C., Chu S.H. (2000) Turbulence characteristics downstream of bileaflet aortic valve prostheses. J. Biomech. Eng. 122:118-124
24. Lu P.C., Lai H.C., Liu J.S. (2001) A reevaluation and discussion on the threshold limit for hemolysis in a turbulent shear flow. J. Biomech. 34:1361-1364
25. McCabe, W. L., J. C. Smith, and P. Harriot. Unit Operations of Chemical Engineering, 5th ed. New York: McGraw-Hill, 1130 pp., 1993.
26. Mohandas N., Chasis J.A., Shohet S.B. (1983) The influence of membrane skeleton on red cell deformability, membrane material properties, and shape. Semin. Hematol. 20:225-242
27. Morariu V.V., Chis A.M., Znamirovschi V. (1996) Fluctuations in red cell membranes. Cytobios 86:53-64
28. Nash G.B., Wyard S.J. (1993) Structural determinants of the rigidity of the red cell membrane. Biorheology 30:397-407
29. Oldshue, J. Y., and N. R. Herbst. A Guide to Fluid Mixing. Rochester, NY: Lightnin, 153 pp., 1992.
30. Papantonis, D. Numerical prediction of the shear stresses and of the mean stay time for radial flow impellers. In: Proc. Int. Workshop on Rotary Blood Pumps, pp. 63-69, 1991.
31. Papoutsakis E.T. (1991) Fluid-Mechanical Damage of Animal Cells in Bioreactors. Trends Biotechnol. 9:427-437
32. Pinotti M. (2000) Is there a correlation between the turbulent eddies size and mechanical hemolysis? J. Braz. Soc. Mech. Sci. 22:565-569
33. Sallam A.M., Hwang N.H. (1983) Influence of red blood cell concentrations on the measurement of turbulence using hot-film anemometer. J. Biomech. Eng. 105:406-410
34. Sallam A.M., Hwang N.H. (1984) Human red blood cell hemolysis in a turbulent shear flow: contribution of Reynolds shear stresses. Biorheology 21:783-797
35. Sanchez Perez J.A., Rodriguez Porcel E.M., Casas Lopez J.L., Fernandez Sevilla J.M., Chisti Y. (2006) Shear rate in stirred tank and bubble column bioreactors. Chem. Eng. J. 124:1-5
36. Schima H., Wieselthaler G. (1995) Mechanically induced blood trauma: are the relevant questions already solved, or is it still an important field to be investigated? Artif. Organs 19:563-564
37. Shimono T., Makinouchi K., Nose Y. (1995) Total erythrocyte destruction time: the new index for the hemolytic performance of rotary blood pumps. Artif. Organs 19:571-575
38. Sutera S.P. (1977) Flow-induced trauma to blood cells. Circ. Res. 41:2-8
39. Tamagawa M., Akamatsu T., Saitoh K. (1996) Prediction of hemolysis in turbulent shear orifice flow. Artif. Organs 20:553-559
40. Waugh R.E. (1982) Temperature dependence of the yield shear resultant and the plastic viscosity coefficient of erythrocyte membrane. implications about molecular events during membrane failure. Biophys. J. 39:273-278
41. Wells R.E. Jr., Merrill E.W. (1961) Shear rate dependence of the viscosity of whole blood and plasma. Science 133:763-764
42. Wu S.J., Shung K.K., Brasseur J.G. (1998) In situ measurements of Doppler power vs. flow turbulence intensity in red cell suspensions. Ultrasound Med. Biol. 24:1009-1021
43. Zapanta, C. M. Correlation of Prosthetic Heart Valve Dynamics with Cavitation: In Vitro and In Vivo Studies. University Park, Pennsylvania: The Pennsylvania State University, 261 pp., 1997.